The CD200/CD200R signaling pathway contributes to spontaneous functional recovery by enhancing synaptic plasticity after stroke
Sun H, He X, Tao X, Hou T, Chen M, He M, Liao H. The CD200/CD200R signaling pathway contributes to spontaneous functional recovery by enhancing synaptic plasticity after stroke. Journal Of Neuroinflammation 2020, 17: 171. PMID: 32473633, PMCID: PMC7260848, DOI: 10.1186/s12974-020-01845-x.Peer-Reviewed Original ResearchConceptsCD200/CD200RSpontaneous functional recoveryPro-inflammatory factor releaseFunctional recoveryMicroglia activationSynaptic plasticityFactor releaseSensorimotor functionDendritic spinesTransient middle cerebral artery occlusion modelMiddle cerebral artery occlusion modelCD200/CD200R pathwayAdhesive removal testSensorimotor functional recoverySensory function recoveryArtery occlusion modelSynapse-related proteinsImmune modulatory effectsInflammatory factor releaseMultiple brain disordersMechanism of actionIpsilateral cortexNeurological recoveryStroke onsetAcute phase