Melatonin attenuates repeated mild traumatic brain injury-induced cognitive deficits by inhibiting astrocyte reactivation
Cao R, Li L, Zhang W, Lu J, Wang Y, Chen Q, Zhang W, Chen M, Sheng L, Cai K, Xu G. Melatonin attenuates repeated mild traumatic brain injury-induced cognitive deficits by inhibiting astrocyte reactivation. Biochemical And Biophysical Research Communications 2021, 580: 20-27. PMID: 34607259, DOI: 10.1016/j.bbrc.2021.09.025.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryBrain regionsCognitive improvementCognitive deficitsCognition-related brain regionsMild TBI modelMedial prefrontal cortexAstrocyte reactivationCognitive enhancementCognitive functionPrefrontal cortexDifferent brain regionsMelatonin administrationNeuronal activityClosed head injuryEarly pathological stageUse of melatoninMelatonin attenuatesBrain injuryGlial responseNeuroprotective roleTBI modelDeficitsPathological stageHead injury