Oridonin ameliorates acetaminophen‐induced acute liver injury through ATF4/PGC‐1α pathway
Yu D, Li J, Wang Y, Guo D, Zhang X, Chen M, Zhou Z. Oridonin ameliorates acetaminophen‐induced acute liver injury through ATF4/PGC‐1α pathway. Drug Development Research 2022, 84: 211-225. PMID: 36567664, DOI: 10.1002/ddr.22024.Peer-Reviewed Original ResearchConceptsAcute liver injuryPGC-1α pathwayLiver injuryCytochrome P450 2E1 (CYP2E1) levelsEndoplasmic reticulum stress activationOxidative stressP450 2E1 levelsImproved liver functionPotential therapeutic effectsPGC-1α levelsHepatocyte cell deathUnclear molecular mechanismsLiver functionProinflammatory cytokinesHepatic toxicityHepatoprotective effectTherapeutic effectAPAP metabolismATF4 knockdownNecrotic areasWestern blotAPAPMetabolic activationMitochondrial dysfunctionProtein levels