2022
Astrocyte reactivation in medial prefrontal cortex contributes to obesity-promoted depressive-like behaviors
Yu G, Cao F, Hou T, Cheng Y, Jia B, Yu L, Chen W, Xu Y, Chen M, Wang Y. Astrocyte reactivation in medial prefrontal cortex contributes to obesity-promoted depressive-like behaviors. Journal Of Neuroinflammation 2022, 19: 166. PMID: 35761401, PMCID: PMC9235218, DOI: 10.1186/s12974-022-02529-4.Peer-Reviewed Original ResearchConceptsDepressive-like behaviorMedial prefrontal cortexSpontaneous inhibitory postsynaptic currentsSpontaneous excitatory postsynaptic currentsOb/ob miceEmotion-related brain regionsHigh-fat dietAstrocyte reactivationNormal diet miceNeuronal activityBrain regionsGlial reactivationHFD miceSusceptible micePostsynaptic currentsObesogenic factorsOb miceInhibitory postsynaptic currentsNeuronal electrophysiological propertiesRisk of depressionExcitatory postsynaptic currentsWild-type micePrefrontal cortex contributesGlial responseAstrocyte reactivity
2020
Hippocampal microglial activation triggers a neurotoxic-specific astrocyte response and mediates etomidate-induced long-term synaptic inhibition
Li D, Chen M, Meng T, Fei J. Hippocampal microglial activation triggers a neurotoxic-specific astrocyte response and mediates etomidate-induced long-term synaptic inhibition. Journal Of Neuroinflammation 2020, 17: 109. PMID: 32264970, PMCID: PMC7140340, DOI: 10.1186/s12974-020-01799-0.Peer-Reviewed Original ResearchConceptsPostoperative cognitive dysfunctionAstrocyte activationPathological stageAstrocyte responseMicroglial activationCognitive functionSynaptic inhibitionCognitive dysfunctionNovel object recognition testHippocampal microglial activationInitial pathological stageInhibitory postsynaptic currentsSignificant microglial activationLate pathological stageEarly pathological stageMonth old miceObject recognition testMorris water mazeQuantitative polymerase chain reactionMagnetic-activated cell sortingActivated microgliaSedative dosePostsynaptic currentsPolymerase chain reactionMicroglia