Astrocyte reactivation in medial prefrontal cortex contributes to obesity-promoted depressive-like behaviors
Yu G, Cao F, Hou T, Cheng Y, Jia B, Yu L, Chen W, Xu Y, Chen M, Wang Y. Astrocyte reactivation in medial prefrontal cortex contributes to obesity-promoted depressive-like behaviors. Journal Of Neuroinflammation 2022, 19: 166. PMID: 35761401, PMCID: PMC9235218, DOI: 10.1186/s12974-022-02529-4.Peer-Reviewed Original ResearchConceptsDepressive-like behaviorMedial prefrontal cortexSpontaneous inhibitory postsynaptic currentsSpontaneous excitatory postsynaptic currentsOb/ob miceEmotion-related brain regionsHigh-fat dietAstrocyte reactivationNormal diet miceNeuronal activityBrain regionsGlial reactivationHFD miceSusceptible micePostsynaptic currentsObesogenic factorsOb miceInhibitory postsynaptic currentsNeuronal electrophysiological propertiesRisk of depressionExcitatory postsynaptic currentsWild-type micePrefrontal cortex contributesGlial responseAstrocyte reactivity