2021
Melatonin attenuates repeated mild traumatic brain injury-induced cognitive deficits by inhibiting astrocyte reactivation
Cao R, Li L, Zhang W, Lu J, Wang Y, Chen Q, Zhang W, Chen M, Sheng L, Cai K, Xu G. Melatonin attenuates repeated mild traumatic brain injury-induced cognitive deficits by inhibiting astrocyte reactivation. Biochemical And Biophysical Research Communications 2021, 580: 20-27. PMID: 34607259, DOI: 10.1016/j.bbrc.2021.09.025.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryBrain regionsCognitive improvementCognitive deficitsCognition-related brain regionsMild TBI modelMedial prefrontal cortexAstrocyte reactivationCognitive enhancementCognitive functionPrefrontal cortexDifferent brain regionsMelatonin administrationNeuronal activityClosed head injuryEarly pathological stageUse of melatoninMelatonin attenuatesBrain injuryGlial responseNeuroprotective roleTBI modelDeficitsPathological stageHead injury
2020
Hippocampal microglial activation triggers a neurotoxic-specific astrocyte response and mediates etomidate-induced long-term synaptic inhibition
Li D, Chen M, Meng T, Fei J. Hippocampal microglial activation triggers a neurotoxic-specific astrocyte response and mediates etomidate-induced long-term synaptic inhibition. Journal Of Neuroinflammation 2020, 17: 109. PMID: 32264970, PMCID: PMC7140340, DOI: 10.1186/s12974-020-01799-0.Peer-Reviewed Original ResearchConceptsPostoperative cognitive dysfunctionAstrocyte activationPathological stageAstrocyte responseMicroglial activationCognitive functionSynaptic inhibitionCognitive dysfunctionNovel object recognition testHippocampal microglial activationInitial pathological stageInhibitory postsynaptic currentsSignificant microglial activationLate pathological stageEarly pathological stageMonth old miceObject recognition testMorris water mazeQuantitative polymerase chain reactionMagnetic-activated cell sortingActivated microgliaSedative dosePostsynaptic currentsPolymerase chain reactionMicroglia