2020
The CD200/CD200R signaling pathway contributes to spontaneous functional recovery by enhancing synaptic plasticity after stroke
Sun H, He X, Tao X, Hou T, Chen M, He M, Liao H. The CD200/CD200R signaling pathway contributes to spontaneous functional recovery by enhancing synaptic plasticity after stroke. Journal Of Neuroinflammation 2020, 17: 171. PMID: 32473633, PMCID: PMC7260848, DOI: 10.1186/s12974-020-01845-x.Peer-Reviewed Original ResearchConceptsCD200/CD200RSpontaneous functional recoveryPro-inflammatory factor releaseFunctional recoveryMicroglia activationSynaptic plasticityFactor releaseSensorimotor functionDendritic spinesTransient middle cerebral artery occlusion modelMiddle cerebral artery occlusion modelCD200/CD200R pathwayAdhesive removal testSensorimotor functional recoverySensory function recoveryArtery occlusion modelSynapse-related proteinsImmune modulatory effectsInflammatory factor releaseMultiple brain disordersMechanism of actionIpsilateral cortexNeurological recoveryStroke onsetAcute phase
2019
Neurogenesis promoted by the CD200/CD200R signaling pathway following treadmill exercise enhances post-stroke functional recovery in rats
Sun H, Li A, Hou T, Tao X, Chen M, Wu C, Chen S, Zhu L, Liao H. Neurogenesis promoted by the CD200/CD200R signaling pathway following treadmill exercise enhances post-stroke functional recovery in rats. Brain Behavior And Immunity 2019, 82: 354-371. PMID: 31513876, DOI: 10.1016/j.bbi.2019.09.005.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDCell DifferentiationCell ProliferationExercise TestHippocampusInfarction, Middle Cerebral ArteryMaleNeural Stem CellsNeurogenesisNeuronsPhysical Conditioning, AnimalPhysical ExertionRatsRats, Sprague-DawleyReceptors, ImmunologicRecovery of FunctionSignal TransductionStrokeStroke RehabilitationConceptsCD200/CD200RCognitive functional recoveryTransient middle cerebral artery occlusionFunctional recoveryTreadmill exercisePost-stroke functional recoveryMiddle cerebral artery occlusionExercise-induced neurogenesisPre-existing neuronsCerebral artery occlusionNeurotrophic factor expressionLong-term disabilityPromotion of neurogenesisNeural stem/progenitor cell proliferationCommon treatment strategyTNF-α expressionPotential therapeutic targetAugmentation of neurogenesisStem/progenitor cell proliferationPotential molecular mechanismsProgenitor cell proliferationArtery occlusionIpsilateral hippocampusCD200R expressionSubgranular zone