p75NTR Promotes Astrocyte Proliferation in Response to Cortical Stab Wound
Chen M, Guo L, Hao J, Ni J, Lv Q, Xin X, Liao H. p75NTR Promotes Astrocyte Proliferation in Response to Cortical Stab Wound. Cellular And Molecular Neurobiology 2020, 42: 1153-1166. PMID: 33201418, DOI: 10.1007/s10571-020-01006-x.Peer-Reviewed Original ResearchConceptsCortical stab woundAstrocyte proliferationStab woundsMouse astrocytesCell cycle progressionG2/MInjury mouse modelCycle progressionCortical stabP75NTR overexpressionAstrocyte activationFunctional recoveryAstrocytic responseReceptor upregulationBrain traumaAstrocyte apoptosisBrain injuryCDK2 protein levelsMouse modelCDK2 expressionAstrocytesCell cycle entryS phaseProfound alterationsProtein levelsHippocampal microglial activation triggers a neurotoxic-specific astrocyte response and mediates etomidate-induced long-term synaptic inhibition
Li D, Chen M, Meng T, Fei J. Hippocampal microglial activation triggers a neurotoxic-specific astrocyte response and mediates etomidate-induced long-term synaptic inhibition. Journal Of Neuroinflammation 2020, 17: 109. PMID: 32264970, PMCID: PMC7140340, DOI: 10.1186/s12974-020-01799-0.Peer-Reviewed Original ResearchConceptsPostoperative cognitive dysfunctionAstrocyte activationPathological stageAstrocyte responseMicroglial activationCognitive functionSynaptic inhibitionCognitive dysfunctionNovel object recognition testHippocampal microglial activationInitial pathological stageInhibitory postsynaptic currentsSignificant microglial activationLate pathological stageEarly pathological stageMonth old miceObject recognition testMorris water mazeQuantitative polymerase chain reactionMagnetic-activated cell sortingActivated microgliaSedative dosePostsynaptic currentsPolymerase chain reactionMicroglia