2013
Bone morphogenetic proteins prevent bone marrow stromal cell-mediated oligodendroglial differentiation of transplanted adult neural progenitor cells in the injured spinal cord
Sandner B, Rivera FJ, Caioni M, Nicholson L, Eckstein V, Bogdahn U, Aigner L, Blesch A, Weidner N. Bone morphogenetic proteins prevent bone marrow stromal cell-mediated oligodendroglial differentiation of transplanted adult neural progenitor cells in the injured spinal cord. Stem Cell Research 2013, 11: 758-771. PMID: 23770801, DOI: 10.1016/j.scr.2013.05.003.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Marrow TransplantationBone Morphogenetic Protein 2Bone Morphogenetic Protein 4Cell DifferentiationFemaleHumansImmunohistochemistryMesenchymal Stem Cell TransplantationMesenchymal Stem CellsNeural Stem CellsOligodendrogliaRatsRats, Inbred F344Rats, Sprague-DawleyRats, TransgenicSpinal Cord InjuriesConceptsGrafted neural progenitor cellsNeural progenitor cellsBone marrow stromal cellsAdult neural progenitor cellsOligodendroglial differentiationSpinal cordEffect of BMSCsAdult Fischer 344 ratsLoss of oligodendrogliaProgenitor cellsSpinal cord injuryFischer 344 ratsAdult bone marrowOligodendrogenic effectFunctional recoveryCord injuryLesion cavityInjury siteMarrow stromal cellsBone marrowStromal cellsOligodendrogliaBone morphogenetic protein 2/4Rapid upregulationVivo experiments
2012
Dependence of Regenerated Sensory Axons on Continuous Neurotrophin-3 Delivery
Hou S, Nicholson L, van Niekerk E, Motsch M, Blesch A. Dependence of Regenerated Sensory Axons on Continuous Neurotrophin-3 Delivery. Journal Of Neuroscience 2012, 32: 13206-13220. PMID: 22993437, PMCID: PMC3513675, DOI: 10.1523/jneurosci.5041-11.2012.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsAntigensAxonsCell TransplantationCells, CulturedCholera ToxinDisease Models, AnimalDoxycyclineEnzyme-Linked Immunosorbent AssayFemaleGene Expression RegulationGenetic TherapyGlial Fibrillary Acidic ProteinGreen Fluorescent ProteinsHEK293 CellsHumansLamininLeukocyte L1 Antigen ComplexMembrane GlycoproteinsMicrotubule-Associated ProteinsMyelin-Oligodendrocyte GlycoproteinNerve Growth FactorsNerve RegenerationNerve Tissue ProteinsNeurofilament ProteinsNeurotrophin 3ProteoglycansRatsRats, Inbred F344S100 Calcium Binding Protein beta SubunitS100 ProteinsSchwann CellsSciatic NerveSensory Receptor CellsSpinal Cord InjuriesStem Cell TransplantationTime FactorsTransfectionConceptsNT-3 expressionRegenerated sensory axonsRegenerated axonsSensory axonsLesion siteNeurotrophin-3Dorsal column sensory axonsLesion/graft siteNT-3 gene expressionSpinal cord lesion siteCholera toxin βNT-3 deliveryIntrinsic growth capacityBone marrow stromal cellsAxodendritic synapsesConditioning lesionPresynaptic markersAxon numberSpinal cordMarrow stromal cellsSchwann cellsSensory neuronsAdult ratsDoxycycline administrationGraft site