2024
Association of early dexmedetomidine exposure with brain injury biomarker levels following moderate – Severe traumatic brain injury: A TRACK-TBI study
Wongsripuemtet P, Ohnuma T, Temkin N, Barber J, Komisarow J, Manley G, Hatfield J, Treggiari M, Colton K, Sasannejad C, Chaikittisilpa N, Ivins-O’Keefe K, Grandhi R, Laskowitz D, Mathew J, Hernandez A, James M, Raghunathan K, Miller J, Vavilala M, Krishnamoorthy V, investigators T. Association of early dexmedetomidine exposure with brain injury biomarker levels following moderate – Severe traumatic brain injury: A TRACK-TBI study. Journal Of Clinical Neuroscience 2024, 126: 338-347. PMID: 39029302, DOI: 10.1016/j.jocn.2024.07.003.Peer-Reviewed Original ResearchConceptsC-reactive proteinNeuron-specific enolaseGlial fibrillary acidic proteinBiomarker levelsUbiquitin C-terminal hydrolase-L1Traumatic brain injuryDexmedetomidine exposureInjury biomarkersSevere traumatic brain injuryTRACK-TBIS100 calcium-binding protein BInflammatory biomarkers C-reactive proteinCalcium-binding protein BHs-CRP levelsLevel 1 trauma centerRetrospective cohort studyCritically ill TBI patientsAlpha-2 agonistsBrain injuryBrain injury biomarkersBiomarkers C-reactive proteinModulate autonomic functionGlasgow Coma Scale score 3No significant associationSecondary brain injuryUse of Early Ketamine Sedation and Association With Clinical and Cost Outcomes Among Mechanically Ventilated Patients With COVID-19: A Retrospective Cohort Study
Royce-Nagel G, Jarzebowski M, Wongsripuemtet P, Krishnamoorthy V, Fuller M, Ohnuma T, Treggiari M, Yaport M, Cobert J, Garrigan E, Bartz R, Raghunathan K. Use of Early Ketamine Sedation and Association With Clinical and Cost Outcomes Among Mechanically Ventilated Patients With COVID-19: A Retrospective Cohort Study. Critical Care Explorations 2024, 6: e1105. PMID: 38904975, PMCID: PMC11196078, DOI: 10.1097/cce.0000000000001105.Peer-Reviewed Original ResearchConceptsRenal replacement therapyLength of stayHospital length of stayHigher hospital mortalityKetamine infusionTotal hospital costsHospital mortalityVasopressor daysKetamine useVentilator daysSample of U.S. hospitalsRenal replacement therapy useAssociated with higher hospital mortalityDays of mechanical ventilationAssociated with in-hospital mortalityHospital costsManagement of critically ill patientsExtracorporeal membrane oxygenationPropensity score matching analysisRetrospective cohort studyPremier Healthcare DatabaseDays of hospitalizationDays of intubationMechanically ventilated patientsCritically ill patients
2021
Treatments Associated with Lower Mortality among Critically Ill COVID-19 Patients: A Retrospective Cohort Study
Zhao X, Gao C, Dai F, Treggiari MM, Deshpande R, Meng L. Treatments Associated with Lower Mortality among Critically Ill COVID-19 Patients: A Retrospective Cohort Study. Anesthesiology 2021, 135: 1076-1090. PMID: 34597362, DOI: 10.1097/aln.0000000000003999.Peer-Reviewed Original ResearchConceptsIll COVID-19 patientsCOVID-19 patientsPropensity score-matched analysisRetrospective cohort studyLower mortalityHospital mortalityCohort studyMultivariable analysisYale New Haven Health SystemIntensive care unit admissionOrgan support treatmentUse of apixabanCare unit admissionSevere COVID-19Intensive care unitCOVID-19 mortalityLower COVID-19 mortalityApixaban treatmentUnit admissionAspirin treatmentCare unitTreatment AssociatedCandidate treatmentSupport treatmentPatients
2019
Inhaled Iloprost Versus Epoprostenol in Heart Transplant Recipients
Enomoto TM, Treggiari MM, Yanez ND, Merkel MJ. Inhaled Iloprost Versus Epoprostenol in Heart Transplant Recipients. Respiratory Care 2019, 64: 743-751. PMID: 30967439, DOI: 10.4187/respcare.06426.Peer-Reviewed Original ResearchConceptsAcute right ventricular dysfunctionHeart transplant recipientsRight ventricular dysfunctionMechanical ventilationEnd pointHeart transplantationHospital stayTransplant recipientsVentricular dysfunctionHemodynamic valuesMedian numberAcute pulmonary hypertensionLength of ICUOrthotopic heart transplantationPrimary end pointSafety end pointSecondary end pointsImmediate postoperative periodPrimary vasodilatorVasoactive medicationsVasodilatory therapyPostoperative bleedingPulmonary hypertensionPostoperative periodConsecutive patients
2018
Cohort Study of Albumin versus Lactated Ringer's for Postoperative Cardiac Surgery Fluid Resuscitation in the Intensive Care Unit
Fink RJ, Young A, Yanez ND, Hom M, Mai J, Treggiari M, Merkel M. Cohort Study of Albumin versus Lactated Ringer's for Postoperative Cardiac Surgery Fluid Resuscitation in the Intensive Care Unit. Pharmacotherapy The Journal Of Human Pharmacology And Drug Therapy 2018, 38: 1241-1249. PMID: 30403299, DOI: 10.1002/phar.2195.Peer-Reviewed Original ResearchConceptsIntensive care unitPostcardiac surgery patientsCardiovascular intensive care unitFluid resuscitation strategySurgery patientsCare unitCohort studySecondary outcomesAlbumin useResuscitation strategiesPost interventionAfter cohort studyPost-intervention periodPost-intervention time periodsNet cost savingsIntervention time periodFluid resuscitationClinical parametersAlbumin reductionEvidence-based practiceAdmission ordersIntervention periodLactated Ringer'sPatientsEducational interventionRight Ventricular Systolic Performance Determined by 2D Speckle-Tracking Echocardiography and Acute Kidney Injury After Cardiac Surgery
Yockelson SR, Heitner SB, Click S, Geleto G, Treggiari MM, Hutchens MP. Right Ventricular Systolic Performance Determined by 2D Speckle-Tracking Echocardiography and Acute Kidney Injury After Cardiac Surgery. Journal Of Cardiothoracic And Vascular Anesthesia 2018, 33: 725-731. PMID: 30316640, PMCID: PMC6379134, DOI: 10.1053/j.jvca.2018.09.012.Peer-Reviewed Original ResearchConceptsAcute kidney injuryRV systolic pressureSpeckle tracking echocardiographyCardiac surgeryAKI groupTransthoracic echocardiogramKidney injurySystolic pressureMyocardial performanceElevated RV systolic pressureRight ventricular myocardial performanceCardiovascular intensive care unitRetrospective observational cohort studyRV myocardial performancePreoperative serum creatinineCardiac surgery patientsCentral venous pressureObservational cohort studyVentricular systolic performanceSerum creatinine valuesVentricular myocardial performanceBody mass indexIntensive care unitIntravascular volume statusSpeckle-tracking analysisThe use of acute normovolemic hemodilution in paediatric cardiac surgery
Crescini WM, Muralidaran A, Shen I, LeBlanc A, You J, Giacomuzzi C, Treggiari MM. The use of acute normovolemic hemodilution in paediatric cardiac surgery. Acta Anaesthesiologica Scandinavica 2018, 62: 756-764. PMID: 29504128, DOI: 10.1111/aas.13095.Peer-Reviewed Original ResearchConceptsAcute normovolemic hemodilutionPediatric cardiac surgery patientsCardiac surgery patientsBlood productsHospital stayBaseline characteristicsSurgery patientsBlood lossNormovolemic hemodilutionSingle-center retrospective cohort studyUse of ANHHigh blood loss surgeryLower postoperative blood lossCongenital Heart Surgery scoreAllogenic blood productsAllogeneic blood productsDuration of ICUPostoperative blood lossRetrospective cohort studyLower blood lossPediatric cardiac surgeryMonths of ageAnaesthesiologists classificationANH groupPerioperative transfusion
2016
Comparison of enteral ethanol and benzodiazepines for alcohol withdrawal in neurocritical care patients
Gipson G, Tran K, Hoang C, Treggiari M. Comparison of enteral ethanol and benzodiazepines for alcohol withdrawal in neurocritical care patients. Journal Of Clinical Neuroscience 2016, 31: 88-91. PMID: 27262870, DOI: 10.1016/j.jocn.2016.02.028.Peer-Reviewed Original ResearchConceptsEnteral ethanolCIWA scoreAlcohol withdrawalEthanol groupIntensive care unit lengthClinical Institute Withdrawal AssessmentAlcohol withdrawal managementRetrospective chart reviewNeurocritical care patientsGlasgow Coma ScaleLength of stayUse of benzodiazepinesLevel of comaAlcohol scale scoresPrimary endpointSecondary endpointsChart reviewClinical characteristicsFirst medicationCare patientsComa ScaleOral intakeEthanol withdrawalWithdrawal AssessmentNeurocritical careCharacteristics of Sepsis-Induced Cardiac Dysfunction using Speckle-Tracking Echocardiography: A Feasibility Study
Zaky A, Gill EA, Lin CP, Paul CP, Bendjelid K, Treggiari MM. Characteristics of Sepsis-Induced Cardiac Dysfunction using Speckle-Tracking Echocardiography: A Feasibility Study. Anaesthesia And Intensive Care 2016, 44: 65-76. PMID: 26673591, PMCID: PMC5050013, DOI: 10.1177/0310057x1604400111.Peer-Reviewed Original ResearchConceptsLeft ventricular longitudinal strainGlobal left ventricular longitudinal strainEjection fractionSepsis outcomeSepsis-Induced Cardiac DysfunctionLeft ventricular ejection fractionTwo-dimensional speckle trackingBasal anterior segmentLow ejection fractionPrimary study endpointTertiary care centerObservational feasibility studyVentricular ejection fractionDiagnosis of sepsisVentricular longitudinal strainSpeckle-tracking echocardiographyRisk of mortalitySpeckle tracking echocardiographyEnd-diastolic volumeMitral annular displacementLeft ventricular segmentsHospital mortalityHospital lengthHospital staySevere sepsis
2014
Variation in Tracheal Reintubations Among Patients Undergoing Cardiac Surgery Across Washington State Hospitals
Khandelwal N, Dale CR, Benkeser DC, Joffe AM, Yanez ND, Treggiari MM. Variation in Tracheal Reintubations Among Patients Undergoing Cardiac Surgery Across Washington State Hospitals. Journal Of Cardiothoracic And Vascular Anesthesia 2014, 29: 551-559. PMID: 25802193, PMCID: PMC4427545, DOI: 10.1053/j.jvca.2014.11.009.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAirway ExtubationAirway ManagementCardiac Surgical ProceduresCohort StudiesCoronary Artery BypassCritical CareDatabases, FactualFemaleHealth SurveysHumansIntubation, IntratrachealMaleMiddle AgedRetrospective StudiesRisk FactorsSocioeconomic FactorsTreatment FailureTreatment OutcomeWashingtonConceptsIntensive care unitCardiac surgeryWashington State hospitalsNonfederal hospitalsState HospitalAcute care daysGreater hospital volumeOdds of reintubationCoronary artery bypassRetrospective cohort studyPatient-level characteristicsMultivariate logistic regressionSignificant heterogeneityValvular surgeryArtery bypassCohort studyHospital factorsHospital volumePatient characteristicsTracheal reintubationCare unitProcedure characteristicsHospital characteristicsCare daysReintubationPreoperative Consultations for Medicare Patients Undergoing Cataract Surgery
Thilen SR, Treggiari MM, Lange JM, Lowy E, Weaver EM, Wijeysundera DN. Preoperative Consultations for Medicare Patients Undergoing Cataract Surgery. JAMA Internal Medicine 2014, 174: 380-388. PMID: 24366269, PMCID: PMC4167873, DOI: 10.1001/jamainternmed.2013.13426.Peer-Reviewed Original ResearchConceptsPreoperative consultationCataract surgeryHierarchical logistic regression modelingPatients 66 yearsElective surgical proceduresLogistic regression modelingIndex surgeryCohort studyEntire cohortElective proceduresSurgical proceduresMAIN OUTCOMEMedicare beneficiariesSurgeryMedicare Part BAnesthesia providersNational random sampleUrban residenceTemporal trendsRegression modelingConsultationCohortFacility typeSuch consultationsClear guidelines
2013
A Greater Analgesia, Sedation, Delirium Order Set Quality Score Is Associated With a Decreased Duration of Mechanical Ventilation in Cardiovascular Surgery Patients
Dale CR, Bryson CL, Fan VS, Maynard C, Yanez ND, Treggiari MM. A Greater Analgesia, Sedation, Delirium Order Set Quality Score Is Associated With a Decreased Duration of Mechanical Ventilation in Cardiovascular Surgery Patients. Critical Care Medicine 2013, 41: 2610-2617. PMID: 23989171, DOI: 10.1097/ccm.0b013e31829a6ee7.Peer-Reviewed Original ResearchConceptsCardiac surgery patientsMechanical ventilationSurgery patientsCardiac surgeryAverage durationMean durationOrder setsCardiac surgery hospitalCardiovascular surgery patientsDelivery of analgesiaRetrospective cohort studyMultivariable linear regression modelsImproved patient outcomesShorter mean durationNon-federal hospitalsQuality scoresWashington State hospitalsShorter average durationHospital painCohort studyGreater analgesiaHospital factorsPatient factorsDelirium careSurgery HospitalEtomidate, Adrenal Function, and Mortality in Critically Ill Patients
Sunshine JE, Deem S, Weiss NS, Yanez ND, Daniel S, Keech K, Brown M, Treggiari MM. Etomidate, Adrenal Function, and Mortality in Critically Ill Patients. Respiratory Care 2013, 58: 639-646. PMID: 22906838, PMCID: PMC4126750, DOI: 10.4187/respcare.01956.Peer-Reviewed Original ResearchConceptsCritical illness-related corticosteroid insufficiencyIll patientsCorticosteroid insufficiencyHospital mortalityAdrenal functionInduction agentAdrenal function testingPrevious randomized studyRole of etomidateRetrospective cohort studyBaseline illness severityRisk of deathAlternative induction agentHigh-risk populationRisk of mortalitySmall randomized trialsAcademic medical centerNumber of deathsEtomidate administrationEtomidate exposureAdjusted riskCohort studySecondary outcomesOverall mortalityPrimary outcome
2011
The association between fluid balance and outcomes after subarachnoid hemorrhage
Martini RP, Deem S, Brown M, Souter MJ, Yanez ND, Daniel S, Treggiari MM. The association between fluid balance and outcomes after subarachnoid hemorrhage. Neurocritical Care 2011, 17: 191-198. PMID: 21688008, DOI: 10.1007/s12028-011-9573-0.Peer-Reviewed Original ResearchConceptsPositive fluid balanceICU day 3Negative fluid balanceFluid balanceNew strokeSubarachnoid hemorrhageDay 3Early fluid balanceLevel 1 traumaCumulative fluid balanceWorse clinical presentationMultivariable logistic regressionLess urine outputHunt-Hess scoreGreater resource useTCD vasospasmHospital deathHospital mortalityICU admissionTroponin elevationAdmission GCSHospital courseHospital lengthAdult patientsPrimary outcomeIntraoperative adherence to a low tidal volume ventilation strategy in critically ill patients with preexisting acute lung injury
Chaiwat O, Vavilala MS, Philip S, Malakouti A, Neff MJ, Deem S, Treggiari MM, Wang J, Lang JD. Intraoperative adherence to a low tidal volume ventilation strategy in critically ill patients with preexisting acute lung injury. Journal Of Critical Care 2011, 26: 144-151. PMID: 20869200, DOI: 10.1016/j.jcrc.2010.08.002.Peer-Reviewed Original ResearchMeSH KeywordsAcute Lung InjuryAdolescentAdultAgedAged, 80 and overAPACHECritical IllnessFemaleGuideline AdherenceHospital MortalityHumansInjury Severity ScoreIntraoperative PeriodLength of StayMaleMiddle AgedPositive-Pressure RespirationPractice Guidelines as TopicRetrospective StudiesRisk FactorsTidal VolumeYoung AdultConceptsAcute respiratory distress syndromeAcute lung injuryALI/acute respiratory distress syndromeLTV ventilationLung injuryClinical outcomesLow tidal volume ventilation strategyALI/ARDS diagnosisLow tidal volume ventilationVolume ventilation strategyRespiratory distress syndromeTidal volume ventilationARDS diagnosisHospital mortalityIntraoperative adherenceHospital lengthSecondary outcomesSurgical patientsDistress syndromeIll patientsVolume ventilationImproved oxygenationPatient outcomesRetrospective analysisMAIN OUTCOMEThe Second-Generation Air-Q® Intubating Laryngeal Mask for Airway Maintenance during Anaesthesia in Adults: A Report of the First 70 Uses
Joffe AM, Liew EC, Galgon RE, Viernes D, Treggiari MM. The Second-Generation Air-Q® Intubating Laryngeal Mask for Airway Maintenance during Anaesthesia in Adults: A Report of the First 70 Uses. Anaesthesia And Intensive Care 2011, 39: 40-45. PMID: 21375088, DOI: 10.1177/0310057x1103900106.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnesthesia, GeneralEquipment DesignFemaleFiber Optic TechnologyHumansIntubation, IntratrachealLaryngeal MasksMaleRetrospective StudiesConceptsAirway leak pressureLaryngeal airwayAirway maintenancePrimary airwayLeak pressureMedian (IQR [range]) airway leak pressureIntubating Laryngeal MaskPostoperative throat complaintsSupraglottic airway deviceMild sore throatUnanticipated difficult airwayInitial clinical experienceDuration of useEase of insertionOropharyngeal morbidityThroat complaintsRetrospective reviewSore throatDifficult airwayLaryngeal maskAirway devicesInsertion attemptsAirwayClinical experienceIntubation
2009
Management guided by brain tissue oxygen monitoring and outcome following severe traumatic brain injury.
Martini RP, Deem S, Yanez ND, Chesnut RM, Weiss NS, Daniel S, Souter M, Treggiari MM. Management guided by brain tissue oxygen monitoring and outcome following severe traumatic brain injury. Journal Of Neurosurgery 2009, 111: 644-9. PMID: 19392603, DOI: 10.3171/2009.2.jns08998.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainBrain InjuriesCohort StudiesFemaleHealth ResourcesHospital CostsHospital MortalityHumansIntracranial PressureLength of StayMaleMiddle AgedMonitoring, PhysiologicOxygenPrognosisRegression AnalysisRespiration, ArtificialRetrospective StudiesTrauma Severity IndicesTreatment OutcomeConceptsBrain tissue oxygen monitoringHospital mortality rateTissue oxygen monitoringTraumatic brain injurySevere traumatic brain injuryMortality rateBrain injuryHospital lengthNeurological outcomeHospital dischargeClinical managementICP monitoringMedian hospital lengthWorse neurological outcomeHospital resource utilizationOxygen monitoringMain outcome measuresFunctional Independence ScoreIntracranial pressure monitoringSeverity of injuryBaseline characteristicsCohort studyPatient ageMore patientsOsmotic therapyProlonged Propofol Anesthesia Is Not Associated with an Increase in Blood Lactate
Rozet I, Tontisirin N, Vavilala MS, Treggiari MM, Lee LA, Lam AM. Prolonged Propofol Anesthesia Is Not Associated with an Increase in Blood Lactate. Anesthesia & Analgesia 2009, 109: 1105-1110. PMID: 19641048, DOI: 10.1213/ane.0b013e3181b5a220.Peer-Reviewed Original ResearchConceptsPropofol groupVolatile anesthesiaBlood lossAnesthesia timeSpine surgeryElective spine surgeryHigh serum lactateIntraoperative hemodynamic variablesProlonged spine surgeryPropofol infusion syndromeUse of vasopressorsPropofol patientsVA casesASA gradeInfusion syndromeSerum lactateArterial lactatePropofol infusionProspective studyHemodynamic variablesVA patientsPropofol anesthesiaIntraoperative dataLactic acidosisBlood lactate
2006
Risk factors for reperfusion injury after lung transplantation
Cottini SR, Lerch N, de Perrot M, Treggiari MM, Spiliopoulos A, Nicod L, Ricou B. Risk factors for reperfusion injury after lung transplantation. Intensive Care Medicine 2006, 32: 557-563. PMID: 16520995, DOI: 10.1007/s00134-006-0096-7.Peer-Reviewed Original ResearchConceptsReperfusion injuryIntensive care unitPulmonary hypertensionLung transplantationHigher systolic pulmonary pressureSurgical intensive care unitDonor/recipient pairsSystolic pulmonary hypertensionSystolic pulmonary pressureAdministration of catecholaminesDifficult hemostasisSettingRetrospective studyICU mortalityPerioperative hemostasisPostoperative variablesPulmonary pressurePreoperative valuesCare unitMechanical ventilationUniversity HospitalDonor factorsEarly recognitionRisk factorsRecipient pairsRelative odds
2005
Factors Associated with Failure of Noninvasive Positive Pressure Ventilation in the Emergency Department
Merlani PG, Pasquina P, Granier JM, Treggiari M, Rutschmann O, Ricou B. Factors Associated with Failure of Noninvasive Positive Pressure Ventilation in the Emergency Department. Academic Emergency Medicine 2005, 12: 1206-1215. PMID: 16293895, DOI: 10.1197/j.aem.2005.07.018.Peer-Reviewed Original ResearchMeSH KeywordsAgedEmergency Service, HospitalFemaleHospitalizationHumansIntubation, IntratrachealMaleMultivariate AnalysisOutcome and Process Assessment, Health CarePositive-Pressure RespirationPulmonary Disease, Chronic ObstructiveRetrospective StudiesRisk FactorsSensitivity and SpecificitySurvival AnalysisSwitzerlandTreatment FailureConceptsNoninvasive positive pressure ventilationFailure of NPPVAcute respiratory failurePositive pressure ventilationEmergency departmentRespiratory rateRespiratory failurePressure ventilationEndotracheal intubationNPPV failureGlasgow Coma Scale scoreSubsequent endotracheal intubationNegative predictive valueED admissionInstitutional protocolFactors AssociatedPatientsPredictive valueScale scoreMultivariate analysisIntubationVentilationFailureHoursDepartment