2023
Neurologic Complications of Babesiosis, United States, 2011–2021 - Volume 29, Number 6—June 2023 - Emerging Infectious Diseases journal - CDC
Locke S, O’Bryan J, Zubair A, Rethana M, Moffarah A, Krause P, Farhadian S. Neurologic Complications of Babesiosis, United States, 2011–2021 - Volume 29, Number 6—June 2023 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2023, 29: 1127-1135. PMID: 37209667, PMCID: PMC10202888, DOI: 10.3201/eid2906.221890.Peer-Reviewed Original ResearchConceptsNeurologic complicationsNeurologic symptomsRisk factorsYale-New Haven HospitalInfectious Diseases journal - CDCHigh-grade parasitemiaNeurologic risk factorsRange of symptomsAdult patientsRenal failureDiabetes mellitusFrequent symptomsHospital admissionImpaired consciousnessMedical recordsEndemic areasParasitic infectionsPatientsSymptomsIntraerythrocytic protozoaComplicationsBabesiosisNew HavenDeliriumMellitusThe impact of ABO and RhD blood types on Babesia microti infection
Jajosky R, O’Bryan J, Spichler-Moffarah A, Jajosky P, Krause P, Tonnetti L. The impact of ABO and RhD blood types on Babesia microti infection. PLOS Neglected Tropical Diseases 2023, 17: e0011060. PMID: 36696414, PMCID: PMC9901808, DOI: 10.1371/journal.pntd.0011060.Peer-Reviewed Original ResearchConceptsB. microti infectionABO blood typeBabesia microti infectionMicroti infectionBlood donorsBlood typeDisease severityPlasmodium falciparum malaria patientsFalciparum malaria patientsHigher peak parasitemiaRed blood cell antigensType BImpact of ABOBlood cell antigensBlood type BMalaria patientsTransfusion strategyInfected donorsRhD blood typeSevere diseasePeak parasitemiaB antigensCell antigensPossible associationRhD antigen
2022
Prosthetic Joint Infections of the Hip and Knee Among the Elderly: A Retrospective Study
Spichler-Moffarah A, Rubin LE, Bernstein JA, O'Bryan J, McDonald E, Golden M. Prosthetic Joint Infections of the Hip and Knee Among the Elderly: A Retrospective Study. The American Journal Of Medicine 2022, 136: 100-107. PMID: 36063860, DOI: 10.1016/j.amjmed.2022.08.006.Peer-Reviewed Original ResearchConceptsProsthetic joint infectionJoint infectionTotal joint arthroplasty increasesMortality of patientsTertiary medical centerPeriprosthetic joint infectionYears of ageClinical characteristicsOlder patientsGeriatric populationArthroplasty increasesRisk factorsMedical CenterPopulation agesPatientsInfectionMortalityAgeEtiologyHipPrevalenceKneeCardiac Complications of Human Babesiosis
Spichler-Moffarah A, Ong E, O’Bryan J, Krause PJ. Cardiac Complications of Human Babesiosis. Clinical Infectious Diseases 2022, 76: e1385-e1391. PMID: 35983604, PMCID: PMC10169432, DOI: 10.1093/cid/ciac525.Peer-Reviewed Original ResearchConceptsYale-New Haven HospitalCardiac complicationsRisk factorsIntensive care unit stayCardiovascular disease risk factorsHuman babesiosisCommon cardiac complicationHigh-grade parasitemiaLife-threatening complicationsDisease risk factorsLonger median lengthQT interval prolongationHigh mortality rateUnit stayComplication groupTick-borne diseaseAdult patientsCardiac outcomesMost patientsThin blood smearsHeart failureInterval prolongationModerate illnessRecord reviewAtrial fibrillationUnnecessary Routine Use of Mycobacterial Cultures in Patients With Periprosthetic Joint Infections
Golden M, Moffarah AS, Kerantzas C, Rubin L, O’Bryan J. Unnecessary Routine Use of Mycobacterial Cultures in Patients With Periprosthetic Joint Infections. Open Forum Infectious Diseases 2022, 9: ofac132. PMID: 35392456, PMCID: PMC8982768, DOI: 10.1093/ofid/ofac132.Peer-Reviewed Original ResearchLegionella pneumophila and Staphylococcus aureus co-infections in a patient with SARS-CoV-2
Sanchez A, Elliott EI, Wang P, Spichler-Moffarah A. Legionella pneumophila and Staphylococcus aureus co-infections in a patient with SARS-CoV-2. BMJ Case Reports 2022, 15: e248536. PMID: 35232746, PMCID: PMC8889248, DOI: 10.1136/bcr-2021-248536.Peer-Reviewed Original ResearchConceptsCOVID-19 therapySARS-CoV-2Positive SARS-CoV-2 testSARS-CoV-2 testAcute febrile illnessCommunity-acquired pneumoniaSevere COVID-19Patient's successful recoveryCOVID-19COVID-19 managementSecond bacterial infectionMRSA pneumoniaFebrile illnessRespiratory symptomsInitial presentationHigh suspicionLobar pneumoniaWorse outcomesPositive testPatientsBacterial infectionsPneumoniaSuccessful recoveryLegionnaires' diseaseSerogroup 1
2021
A new positive SARS-CoV-2 test months after severe COVID-19 illness: reinfection or intermittent viral shedding?
Tuan J, Spichler-Moffarah A, Ogbuagu O. A new positive SARS-CoV-2 test months after severe COVID-19 illness: reinfection or intermittent viral shedding? BMJ Case Reports 2021, 14: e240531. PMID: 33542020, PMCID: PMC8098910, DOI: 10.1136/bcr-2020-240531.Peer-Reviewed Case Reports and Technical NotesConceptsSARS-CoV-2 RNA testSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2SARS-CoV-2 reinfectionSevere COVID-19 illnessRespiratory syndrome coronavirus 2COVID-19 reinfectionLong asymptomatic periodCOVID-19 illnessSyndrome coronavirus 2Intermittent viral sheddingAsymptomatic periodViral sheddingRNA testCoronavirus 2Clinical managementPersistent infectionDisease 4Molecular testingReinfectionRNA PCRCurrent presentationPotential casesMonthsPatientsDiagnosis of Pneumonia Due to Invasive Molds
Foppiano Palacios C, Spichler Moffarah A. Diagnosis of Pneumonia Due to Invasive Molds. Diagnostics. 2021; 11(7):1226.Peer-Reviewed Original Research
2020
Mycobacterium marinum: nodular hand lesions after a fishing expedition
Tuan J, Spichler-Moffarah A, Ogbuagu O. Mycobacterium marinum: nodular hand lesions after a fishing expedition. BMJ Case Reports 2020, 13: e238835. PMID: 33318281, PMCID: PMC7737068, DOI: 10.1136/bcr-2020-238835.Peer-Reviewed Case Reports and Technical NotesConceptsSoft tissue infectionsDeep space infectionsTissue infectionsSpace infectionAcid-fast bacilliTreatment of skinNon-tuberculous mycobacteriaTerms of treatmentDisseminated diseaseOptimal regimenHand lesionsMedical managementExtremity lesionsCombination therapyInfectionLesionsAddition of rifampicinFurther dataSkinTreatmentMycobacteriaOsteomyelitisRegimenPatientsSurgery
2016
Skin and Soft Tissue Infection
In Diagnostic Microbiology of the Immmunocompromised Host, Second Edition/ American Society of MicrobiologyBooks
2015
Microbiology of diabetic foot infections: from Louis Pasteur to 'crime scene investigation'.
Spichler A, Hurwitz BL, Armstrong DG, Lipsky BA. Microbiology of diabetic foot infections: from Louis Pasteur to 'crime scene investigation'. BMC Medicine 2015, 13: 2. PMID: 25564342, PMCID: PMC4286146, DOI: 10.1186/s12916-014-0232-0.Peer-Reviewed Original Research
2014
Leptospirose - Diagnostico e Manejo Clinico
http://www.saude.gov.br/images/pdf/2015/janeiro/16/Leptospirose-diagnostico-manejo-clinico.pdfPeer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsRoteiro para capacitação de profissionais médicos no diagnóstico e tratamento da leptospirose/Brazilian Ministry of Health
http://www.saude.gov.br/images/pdf/2014/setembro/08/Roteiro-capacitacao-leptospirose-aluno.pdfPeer-Reviewed Educational Materials
2011
Hemoptysis Associated with Leptospirosis Acquired in Hawaii, USA - Volume 17, Number 12—December 2011 - Emerging Infectious Diseases journal - CDC
Duplessis CA, Sklar MJ, Maves RC, Spichler A, Hale B, Johnson M, Bavaro M, Vinetz JM. Hemoptysis Associated with Leptospirosis Acquired in Hawaii, USA - Volume 17, Number 12—December 2011 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2011, 17: 2375-2377. PMID: 22172093, PMCID: PMC3311216, DOI: 10.3201/eid1712.110700.Peer-Reviewed Original ResearchOutpatient follow-up of patients hospitalized for acute leptospirosis
Spichler A, Athanazio D, Seguro AC, Vinetz JM. Outpatient follow-up of patients hospitalized for acute leptospirosis. International Journal Of Infectious Diseases 2011, 15: e486-e490. PMID: 21616696, PMCID: PMC3117907, DOI: 10.1016/j.ijid.2011.03.020.Peer-Reviewed Original ResearchConceptsAcute leptospirosisHospital dischargeLate complicationsOutcome of leptospirosisChronic sequelaeProspective studyGeneral malaiseOutpatient settingPossible sequelaeAcute diseaseChronic diseasesMild casesSubjective complaintsFirst visitSame patientPatientsSecond visitPanic disorderObjective evidenceLeptospirosisStudy periodVisitsComplicationsSequelaeDisease
2010
DOENÇAS INFECCIOSAS E PARASITÁRIAS - Coordenação de Vigilância das Doenças Transmitidas por Vetores e Antropozoonoses
http://bvsms.saude.gov.br/bvs/publicacoes/doencas_infecciosas_parasitaria_guia_bolso.pdfPeer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2009
Brazilian Spotted Fever /Norma Tecnica para Vigilancia Epidemiologica da Febre maculosa em Sao Paulo
https://cievspalmas.files.wordpress.com/2012/03/normatecnica-para-a-vigilc3a2ncia-epidemiologica-da-febre-maculosa-brasileira-em-sc3a3o-paulo.pdfPeer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2008
Case report: severe, symptomatic hypomagnesemia in acute leptospirosis.
Spichler A, Athanazio DA, Furtado J, Seguro A, Vinetz JM. Case report: severe, symptomatic hypomagnesemia in acute leptospirosis. American Journal Of Tropical Medicine And Hygiene 2008, 79: 915-7. PMID: 19052304, PMCID: PMC2637037, DOI: 10.4269/ajtmh.2008.79.915.Peer-Reviewed Original ResearchConceptsNon-oliguric acute kidney injuryNon-oliguric acute renal failureAcute kidney injuryAcute renal failureKidney injuryRenal failureSevere hypomagnesemiaAcute phaseAcute leptospirosisClinical complicationsMagnesium replacementSymptomatic hypomagnesemiaMagnesium wastingLarge dosesMagnesium imbalanceLeptospirosisHypomagnesemiaBiochemical studiesComplicationsInjuryDiseaseDosesWastingPredictors of lethality in severe leptospirosis in urban Brazil.
Spichler AS, Vilaça PJ, Athanazio DA, Albuquerque JO, Buzzar M, Castro B, Seguro A, Vinetz JM. Predictors of lethality in severe leptospirosis in urban Brazil. American Journal Of Tropical Medicine And Hygiene 2008, 79: 911-4. PMID: 19052303, PMCID: PMC2640419, DOI: 10.4269/ajtmh.2008.79.911.Peer-Reviewed Original ResearchConceptsSevere leptospirosisRetrospective case-control studyPopulation-based surveillance dataDevelopment of oliguriaPredictors of deathStrong risk factorCase-control studyPredictors of lethalityDeath certificate reportingLung involvementPulmonary involvementPrognostic factorsSerologic findingsFatal outcomePatient hospitalizationRisk factorsSurvivor casesOdds ratioLethal casesHigh titersLeptospirosis casesSurveillance dataLeptospira interrogansLeptospirosisHospitalization
2007
Reversal of renal tubule transporter downregulation during severe leptospirosis with antimicrobial therapy.
Spichler A, Ko AI, Silva EF, De Brito T, Silva AM, Athanazio D, Silva C, Seguro A. Reversal of renal tubule transporter downregulation during severe leptospirosis with antimicrobial therapy. American Journal Of Tropical Medicine And Hygiene 2007, 77: 1111-9. PMID: 18165532, DOI: 10.4269/ajtmh.2007.77.1111.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcysteineAmpicillinAnimalsAnti-Bacterial AgentsAntigens, BacterialCricetinaeDown-RegulationFemaleFree Radical ScavengersGene Expression ProfilingGene Expression RegulationKidneyLiverMesocricetusSodium-Hydrogen Exchanger 3Sodium-Hydrogen ExchangersSodium-Potassium-Chloride SymportersSolute Carrier Family 12, Member 1ThiobarbituratesWeil DiseaseConceptsSevere leptospirosisAntimicrobial therapyN-acetylcysteineSerum thiobarbituric acidEvidence of benefitThick ascending limbNKCC2 transportersRenal involvementRenal expressionTubular dysfunctionAntioxidant therapyInfected hamstersTubular defectsNAC effectAscending limbAmpicillin treatmentRenal transportersTherapyTarget tissuesLeptospiral antigensAMP treatmentType 3Reduced levelsTransporter downregulationNormal expression