2022
Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus
Duy PQ, Weise SC, Marini C, Li XJ, Liang D, Dahl PJ, Ma S, Spajic A, Dong W, Juusola J, Kiziltug E, Kundishora AJ, Koundal S, Pedram MZ, Torres-Fernández LA, Händler K, De Domenico E, Becker M, Ulas T, Juranek SA, Cuevas E, Hao LT, Jux B, Sousa AMM, Liu F, Kim SK, Li M, Yang Y, Takeo Y, Duque A, Nelson-Williams C, Ha Y, Selvaganesan K, Robert SM, Singh AK, Allington G, Furey CG, Timberlake AT, Reeves BC, Smith H, Dunbar A, DeSpenza T, Goto J, Marlier A, Moreno-De-Luca A, Yu X, Butler WE, Carter BS, Lake EMR, Constable RT, Rakic P, Lin H, Deniz E, Benveniste H, Malvankar NS, Estrada-Veras JI, Walsh CA, Alper SL, Schultze JL, Paeschke K, Doetzlhofer A, Wulczyn FG, Jin SC, Lifton RP, Sestan N, Kolanus W, Kahle KT. Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus. Nature Neuroscience 2022, 25: 458-473. PMID: 35379995, PMCID: PMC9664907, DOI: 10.1038/s41593-022-01043-3.Peer-Reviewed Original ResearchConceptsCongenital hydrocephalusCerebral ventricular dilatationPrimary defectNeuroepithelial cell differentiationRisk genesCerebrospinal fluid homeostasisWhole-exome sequencingNeuroepithelial stem cellsCortical hypoplasiaReduced neurogenesisVentricular dilatationVentricular enlargementCH mutationsPrenatal hydrocephalusDisease heterogeneityBrain surgeryCSF circulationHydrocephalusGenetic subtypesFluid homeostasisNeuroepithelial cellsNovo mutationsBrain transcriptomicsStem cellsCell differentiation
2020
Light Has Diverse Spatiotemporal Molecular Changes in the Mouse Suprachiasmatic Nucleus
Duy PQ, Komal R, Richardson MES, Hahm KS, Fernandez DC, Hattar S. Light Has Diverse Spatiotemporal Molecular Changes in the Mouse Suprachiasmatic Nucleus. Journal Of Biological Rhythms 2020, 35: 576-587. PMID: 33030409, PMCID: PMC10046259, DOI: 10.1177/0748730420961214.Peer-Reviewed Original ResearchRetinal innervation tunes circuits that drive nonphotic entrainment to food
Fernandez DC, Komal R, Langel J, Ma J, Duy PQ, Penzo MA, Zhao H, Hattar S. Retinal innervation tunes circuits that drive nonphotic entrainment to food. Nature 2020, 581: 194-198. PMID: 32404998, PMCID: PMC7291822, DOI: 10.1038/s41586-020-2204-1.Peer-Reviewed Original ResearchConceptsTime-restricted feedingEarly postnatal stagesPostnatal stagesAdult miceIntergeniculate leafletPhotosensitive retinal ganglion cellsRetinal ganglion cellsEarly postnatal periodFood anticipatory activityIGL neuronsGanglion cellsPostnatal periodRetinal inputIpRGCsAcute inhibitionCentral circadian pacemakerPhotic informationTime cuesMajor time cueSuprachiasmatic nucleusInnervationNonphotic cuesMiceNeuronsNonphotic entrainment