Publications

2026

Molecular mechanisms governing the action of the epidermal growth factor receptor and receptor tyrosine kinases, a personal perspective
Schlessinger J. Molecular mechanisms governing the action of the epidermal growth factor receptor and receptor tyrosine kinases, a personal perspective. Philosophical Transactions Of The Royal Society B Biological Sciences 2026, 381: 20240498. PMID: 42656154, DOI: 10.1098/rstb.2024.0498.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
MeSH Keywords
AgRP neurons are required for the weight-lowering effects of GLP-1 receptor agonists in female mice
d’Ávila M, Cavalcanti-de-Albuquerque J, Collado-Pérez R, Liu Z, Hunter J, White A, Schlessinger J, D’Agostino G, Horvath T. AgRP neurons are required for the weight-lowering effects of GLP-1 receptor agonists in female mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 2026, 123: e2614476123. PMID: 42550908, PMCID: PMC13462369, DOI: 10.1073/pnas.2614476123.
Peer-Reviewed Original Research
MeSH Keywords
Reply to Hojný et al.: Fusion-driven vs. fusion-negative high-grade endometrial stromal sarcoma
Hartwich T, Choi J, Schlessinger J, Santin A. Reply to Hojný et al.: Fusion-driven vs. fusion-negative high-grade endometrial stromal sarcoma. Proceedings Of The National Academy Of Sciences Of The United States Of America 2026, 123: e2611558123. PMID: 42313985, PMCID: PMC13320688, DOI: 10.1073/pnas.2611558123.
Commentaries, Editorials and Letters
Cellular responses to FGF1 are modulated by palmitoylation of the docking protein FRS2α
An S, Suzuki Y, Mohanty J, Tome F, Lax I, Schlessinger J. Cellular responses to FGF1 are modulated by palmitoylation of the docking protein FRS2α. Proceedings Of The National Academy Of Sciences Of The United States Of America 2026, 123: e2605311123. PMID: 42054356, PMCID: PMC13143043, DOI: 10.1073/pnas.2605311123.
Peer-Reviewed Original Research
MeSH Keywords
Integrated mutational landscape analysis of endometrial stromal sarcoma
Hartwich T, Choi S, Hwang A, Bellone S, Palmieri L, Seo H, Kim T, Hong J, Krakstad C, Trovik J, Stefansson I, Haugland H, Greenman M, Ettorre V, Ottum S, Demirkiran C, Yang-Hartwich Y, Buza N, Hui P, Lopez S, Cormio G, Ramunno M, Zito A, Perrone E, Fagotti A, Fanfani F, Santoro A, Ravaggi A, Bignotti E, Odicino F, Ardighieri L, Ratner E, Angioli R, Perrone G, Luvero D, Conca B, Choi J, Schlessinger J, Santin A. Integrated mutational landscape analysis of endometrial stromal sarcoma. Proceedings Of The National Academy Of Sciences Of The United States Of America 2026, 123: e2531105123. PMID: 41591910, PMCID: PMC12867622, DOI: 10.1073/pnas.2531105123.
Peer-Reviewed Original Research
MeSH Keywords

2025

Neuronal ALKAL2 and its ALK receptor contribute to the development of colitis-associated colorectal cancer
Delanne-Cuménal M, Defaye M, Delanne-Cuménal A, Ahmed M, Ho V, Abdullah N, Alhassoun M, Svendsen K, Mager L, Schlessinger J, Hirota S, Altier C. Neuronal ALKAL2 and its ALK receptor contribute to the development of colitis-associated colorectal cancer. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2500632122. PMID: 40493183, PMCID: PMC12184428, DOI: 10.1073/pnas.2500632122.
Peer-Reviewed Original Research
MeSH Keywords
Inducible FAK loss but not FAK inhibition in endothelial cells of PYK2-null mice activates p53 tumor suppressor to prevent tumor growth
Chen X, Ojalill M, Jean C, Tancioni I, Jiang S, Boyer A, Ozmadenci D, Uryu S, Tarin D, Schlessinger J, Stupack D, Schlaepfer D. Inducible FAK loss but not FAK inhibition in endothelial cells of PYK2-null mice activates p53 tumor suppressor to prevent tumor growth. Molecular Biology Of The Cell 2025, 36: ar64. PMID: 40202821, PMCID: PMC12206508, DOI: 10.1091/mbc.e24-12-0562.
Peer-Reviewed Original Research
MeSH Keywords

2024

Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies
Edman N, Phal A, Redler R, Schlichthaerle T, Srivatsan S, Ehnes D, Etemadi A, An S, Favor A, Li Z, Praetorius F, Gordon M, Vincent T, Marchiano S, Blakely L, Lin C, Yang W, Coventry B, Hicks D, Cao L, Bethel N, Heine P, Murray A, Gerben S, Carter L, Miranda M, Negahdari B, Lee S, Trapnell C, Zheng Y, Murry C, Schweppe D, Freedman B, Stewart L, Ekiert D, Schlessinger J, Shendure J, Bhabha G, Ruohola-Baker H, Baker D. Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies. Cell 2024, 187: 3726-3740.e43. PMID: 38861993, PMCID: PMC11246234, DOI: 10.1016/j.cell.2024.05.025.
Peer-Reviewed Original Research
MeSH Keywords
Expression of Concern: Pyk2 Is Required for Neutrophil Degranulation and Host Defense Responses to Bacterial Infection.
Kamen L, Schlessinger J, Lowell C. Expression of Concern: Pyk2 Is Required for Neutrophil Degranulation and Host Defense Responses to Bacterial Infection. The Journal Of Immunology 2024, 212: 1604. PMID: 38709995, DOI: 10.4049/jimmunol.2400137.
Peer-Reviewed Original Research
Integrated mutational landscape analysis of poorly differentiated high-grade neuroendocrine carcinoma of the uterine cervix
Bellone S, Jeong K, Halle M, Krakstad C, McNamara B, Greenman M, Mutlu L, Demirkiran C, Hartwich T, Yang-Hartwich Y, Zipponi M, Buza N, Hui P, Raspagliesi F, Lopez S, Paolini B, Milione M, Perrone E, Scambia G, Altwerger G, Ravaggi A, Bignotti E, Huang G, Andikyan V, Clark M, Ratner E, Azodi M, Schwartz P, Quick C, Angioli R, Terranova C, Zaidi S, Nandi S, Alexandrov L, Siegel E, Choi J, Schlessinger J, Santin A. Integrated mutational landscape analysis of poorly differentiated high-grade neuroendocrine carcinoma of the uterine cervix. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2321898121. PMID: 38625939, PMCID: PMC11046577, DOI: 10.1073/pnas.2321898121.
Peer-Reviewed Original Research
MeSH Keywords

2023

Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention
Krimmer S, Bertoletti N, Suzuki Y, Katic L, Mohanty J, Shu S, Lee S, Lax I, Mi W, Schlessinger J. Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2300054120. PMID: 36943885, PMCID: PMC10068818, DOI: 10.1073/pnas.2300054120.
Peer-Reviewed Original Research
MeSH Keywords
Uterine leiomyosarcomas harboring MAP2K4 gene amplification are sensitive in vivo to PLX8725, a novel MAP2K4 inhibitor
McNamara B, Harold J, Manavella D, Bellone S, Mutlu L, Hartwich T, Zipponi M, Yang-Hartwich Y, Demirkiran C, Verzosa M, Yang K, Choi J, Dong W, Buza N, Hui P, Altwerger G, Huang G, Andikyan V, Clark M, Ratner E, Azodi M, Schwartz P, Burton E, Inagaki H, Albers A, Zhang C, Bollag G, Schlessinger J, Santin A. Uterine leiomyosarcomas harboring MAP2K4 gene amplification are sensitive in vivo to PLX8725, a novel MAP2K4 inhibitor. Gynecologic Oncology 2023, 172: 65-71. PMID: 36958197, PMCID: PMC10192120, DOI: 10.1016/j.ygyno.2023.03.009.
Peer-Reviewed Original Research
MeSH Keywords
Heparin is essential for optimal cell signaling by FGF21 and for regulation of βKlotho cellular stability
An S, Mohanty J, Tome F, Suzuki Y, Lax I, Schlessinger J. Heparin is essential for optimal cell signaling by FGF21 and for regulation of βKlotho cellular stability. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2219128120. PMID: 36745784, PMCID: PMC9962926, DOI: 10.1073/pnas.2219128120.
Peer-Reviewed Original Research
MeSH Keywords

2022

Regulation of EGF-stimulated activation of the PI-3K/AKT pathway by exocyst-mediated exocytosis
An S, Anneken A, Xi Z, Choi C, Schlessinger J, Toomre D. Regulation of EGF-stimulated activation of the PI-3K/AKT pathway by exocyst-mediated exocytosis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2208947119. PMID: 36417441, PMCID: PMC9860279, DOI: 10.1073/pnas.2208947119.
Peer-Reviewed Original Research
MeSH Keywords
Isoform-specific inhibition of FGFR signaling achieved by a de-novo-designed mini-protein
Park JS, Choi J, Cao L, Mohanty J, Suzuki Y, Park A, Baker D, Schlessinger J, Lee S. Isoform-specific inhibition of FGFR signaling achieved by a de-novo-designed mini-protein. Cell Reports 2022, 41: 111545. PMID: 36288716, PMCID: PMC9636537, DOI: 10.1016/j.celrep.2022.111545.
Peer-Reviewed Original Research
MeSH Keywords
Insights on JAK2 Modulation by Potent, Selective, and Cell-Permeable Pseudokinase-Domain Ligands
Liosi ME, Ippolito JA, Henry SP, Krimmer SG, Newton AS, Cutrona KJ, Olivarez RA, Mohanty J, Schlessinger J, Jorgensen WL. Insights on JAK2 Modulation by Potent, Selective, and Cell-Permeable Pseudokinase-Domain Ligands. Journal Of Medicinal Chemistry 2022, 65: 8380-8400. PMID: 35653642, PMCID: PMC9939005, DOI: 10.1021/acs.jmedchem.2c00283.
Peer-Reviewed Original Research
MeSH Keywords
Conversion of a False Virtual Screen Hit into Selective JAK2 JH2 Domain Binders Using Convergent Design Strategies
Henry SP, Liosi ME, Ippolito JA, Cutrona KJ, Krimmer SG, Newton AS, Schlessinger J, Jorgensen WL. Conversion of a False Virtual Screen Hit into Selective JAK2 JH2 Domain Binders Using Convergent Design Strategies. ACS Medicinal Chemistry Letters 2022, 13: 819-826. PMID: 35586418, PMCID: PMC9109162, DOI: 10.1021/acsmedchemlett.2c00051.
Peer-Reviewed Original Research
A hypothalamic pathway for Augmentor α–controlled body weight regulation
Ahmed M, Kaur N, Cheng Q, Shanabrough M, Tretiakov EO, Harkany T, Horvath TL, Schlessinger J. A hypothalamic pathway for Augmentor α–controlled body weight regulation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2200476119. PMID: 35412887, PMCID: PMC9169862, DOI: 10.1073/pnas.2200476119.
Peer-Reviewed Original Research
MeSH Keywords
Design of protein-binding proteins from the target structure alone
Cao L, Coventry B, Goreshnik I, Huang B, Sheffler W, Park JS, Jude KM, Marković I, Kadam RU, Verschueren KHG, Verstraete K, Walsh STR, Bennett N, Phal A, Yang A, Kozodoy L, DeWitt M, Picton L, Miller L, Strauch EM, DeBouver ND, Pires A, Bera AK, Halabiya S, Hammerson B, Yang W, Bernard S, Stewart L, Wilson IA, Ruohola-Baker H, Schlessinger J, Lee S, Savvides SN, Garcia KC, Baker D. Design of protein-binding proteins from the target structure alone. Nature 2022, 605: 551-560. PMID: 35332283, PMCID: PMC9117152, DOI: 10.1038/s41586-022-04654-9.
Peer-Reviewed Original Research
MeSH Keywords

2021

Structural basis for ligand reception by anaplastic lymphoma kinase
Li T, Stayrook SE, Tsutsui Y, Zhang J, Wang Y, Li H, Proffitt A, Krimmer SG, Ahmed M, Belliveau O, Walker IX, Mudumbi KC, Suzuki Y, Lax I, Alvarado D, Lemmon MA, Schlessinger J, Klein DE. Structural basis for ligand reception by anaplastic lymphoma kinase. Nature 2021, 600: 148-152. PMID: 34819665, PMCID: PMC8639777, DOI: 10.1038/s41586-021-04141-7.
Peer-Reviewed Original Research
MeSH Keywords
Mechanism for the activation of the anaplastic lymphoma kinase receptor
Reshetnyak AV, Rossi P, Myasnikov AG, Sowaileh M, Mohanty J, Nourse A, Miller DJ, Lax I, Schlessinger J, Kalodimos CG. Mechanism for the activation of the anaplastic lymphoma kinase receptor. Nature 2021, 600: 153-157. PMID: 34819673, PMCID: PMC8639797, DOI: 10.1038/s41586-021-04140-8.
Peer-Reviewed Original Research
MeSH Keywords
Indoloxytriazines as binding molecules for the JAK2 JH2 pseudokinase domain and its V617F variant
Newton AS, Liosi ME, Henry SP, Deiana L, Faver JC, Krimmer SG, Puleo DE, Schlessinger J, Jorgensen WL. Indoloxytriazines as binding molecules for the JAK2 JH2 pseudokinase domain and its V617F variant. Tetrahedron Letters 2021, 77: 153248. PMID: 34393283, PMCID: PMC8357305, DOI: 10.1016/j.tetlet.2021.153248.
Peer-Reviewed Original Research
Integrated mutational landscape analysis of uterine leiomyosarcomas
Choi J, Manzano A, Dong W, Bellone S, Bonazzoli E, Zammataro L, Yao X, Deshpande A, Zaidi S, Guglielmi A, Gnutti B, Nagarkatti N, Tymon-Rosario JR, Harold J, Mauricio D, Zeybek B, Menderes G, Altwerger G, Jeong K, Zhao S, Buza N, Hui P, Ravaggi A, Bignotti E, Romani C, Todeschini P, Zanotti L, Odicino F, Pecorelli S, Ardighieri L, Bilguvar K, Quick CM, Silasi DA, Huang GS, Andikyan V, Clark M, Ratner E, Azodi M, Imielinski M, Schwartz PE, Alexandrov LB, Lifton RP, Schlessinger J, Santin AD. Integrated mutational landscape analysis of uterine leiomyosarcomas. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2025182118. PMID: 33876771, PMCID: PMC8053980, DOI: 10.1073/pnas.2025182118.
Peer-Reviewed Original Research
MeSH Keywords

2020

See All Publications

Publications

2026

Molecular mechanisms governing the action of the epidermal growth factor receptor and receptor tyrosine kinases, a personal perspective

AgRP neurons are required for the weight-lowering effects of GLP-1 receptor agonists in female mice

Reply to Hojný et al.: Fusion-driven vs. fusion-negative high-grade endometrial stromal sarcoma

Cellular responses to FGF1 are modulated by palmitoylation of the docking protein FRS2α

Integrated mutational landscape analysis of endometrial stromal sarcoma

2025

Neuronal ALKAL2 and its ALK receptor contribute to the development of colitis-associated colorectal cancer

Inducible FAK loss but not FAK inhibition in endothelial cells of PYK2-null mice activates p53 tumor suppressor to prevent tumor growth

2024

Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies

Expression of Concern: Pyk2 Is Required for Neutrophil Degranulation and Host Defense Responses to Bacterial Infection.

Integrated mutational landscape analysis of poorly differentiated high-grade neuroendocrine carcinoma of the uterine cervix

2023

Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention

Uterine leiomyosarcomas harboring MAP2K4 gene amplification are sensitive in vivo to PLX8725, a novel MAP2K4 inhibitor

Heparin is essential for optimal cell signaling by FGF21 and for regulation of βKlotho cellular stability

2022

Regulation of EGF-stimulated activation of the PI-3K/AKT pathway by exocyst-mediated exocytosis

Isoform-specific inhibition of FGFR signaling achieved by a de-novo-designed mini-protein

Insights on JAK2 Modulation by Potent, Selective, and Cell-Permeable Pseudokinase-Domain Ligands

Conversion of a False Virtual Screen Hit into Selective JAK2 JH2 Domain Binders Using Convergent Design Strategies

A hypothalamic pathway for Augmentor α–controlled body weight regulation

Design of protein-binding proteins from the target structure alone

2021

Structural basis for ligand reception by anaplastic lymphoma kinase

Mechanism for the activation of the anaplastic lymphoma kinase receptor

Indoloxytriazines as binding molecules for the JAK2 JH2 pseudokinase domain and its V617F variant

Integrated mutational landscape analysis of uterine leiomyosarcomas

2020

FGF23 contains two distinct high-affinity binding sites enabling bivalent interactions with α-Klotho

Scaffold association factor B (SAFB) is required for expression of prenyltransferases and RAS membrane association