Publications

2026

AgRP neurons are required for the weight-lowering effects of GLP-1 receptor agonists in female mice.
d'Ávila M, Cavalcanti-de-Albuquerque J, Collado-Pérez R, Liu ZW, Hunter J, White A, Schlessinger J, D'Agostino G, Horvath TL. AgRP neurons are required for the weight-lowering effects of GLP-1 receptor agonists in female mice. Proc Natl Acad Sci U S A 2026, 123: e2614476123. PMID: 42550908, DOI: 10.1073/pnas.2614476123.
Peer-Reviewed Original Research
Reply to Hojný et al.: Fusion-driven vs. fusion-negative high-grade endometrial stromal sarcoma
Hartwich T, Choi J, Schlessinger J, Santin A. Reply to Hojný et al.: Fusion-driven vs. fusion-negative high-grade endometrial stromal sarcoma. Proceedings Of The National Academy Of Sciences Of The United States Of America 2026, 123: e2611558123. PMID: 42313985, DOI: 10.1073/pnas.2611558123.
Peer-Reviewed Original Research
Cellular responses to FGF1 are modulated by palmitoylation of the docking protein FRS2α
An S, Suzuki Y, Mohanty J, Tome F, Lax I, Schlessinger J. Cellular responses to FGF1 are modulated by palmitoylation of the docking protein FRS2α. Proceedings Of The National Academy Of Sciences Of The United States Of America 2026, 123: e2605311123. PMID: 42054356, PMCID: PMC13143043, DOI: 10.1073/pnas.2605311123.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Integrated mutational landscape analysis of endometrial stromal sarcoma
Hartwich T, Choi S, Hwang A, Bellone S, Palmieri L, Seo H, Kim T, Hong J, Krakstad C, Trovik J, Stefansson I, Haugland H, Greenman M, Ettorre V, Ottum S, Demirkiran C, Yang-Hartwich Y, Buza N, Hui P, Lopez S, Cormio G, Ramunno M, Zito A, Perrone E, Fagotti A, Fanfani F, Santoro A, Ravaggi A, Bignotti E, Odicino F, Ardighieri L, Ratner E, Angioli R, Perrone G, Luvero D, Conca B, Choi J, Schlessinger J, Santin A. Integrated mutational landscape analysis of endometrial stromal sarcoma. Proceedings Of The National Academy Of Sciences Of The United States Of America 2026, 123: e2531105123. PMID: 41591910, PMCID: PMC12867622, DOI: 10.1073/pnas.2531105123.
Peer-Reviewed Original Research
MeSH Keywords and Concepts

Publications

2026

AgRP neurons are required for the weight-lowering effects of GLP-1 receptor agonists in female mice.

Reply to Hojný et al.: Fusion-driven vs. fusion-negative high-grade endometrial stromal sarcoma

Cellular responses to FGF1 are modulated by palmitoylation of the docking protein FRS2α

Integrated mutational landscape analysis of endometrial stromal sarcoma

2025

Neuronal ALKAL2 and its ALK receptor contribute to the development of colitis-associated colorectal cancer

Inducible FAK loss but not FAK inhibition in endothelial cells of PYK2-null mice activates p53 tumor suppressor to prevent tumor growth

2024

Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies

Expression of Concern: Pyk2 Is Required for Neutrophil Degranulation and Host Defense Responses to Bacterial Infection.

Integrated mutational landscape analysis of poorly differentiated high-grade neuroendocrine carcinoma of the uterine cervix

2023

Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention

Uterine leiomyosarcomas harboring MAP2K4 gene amplification are sensitive in vivo to PLX8725, a novel MAP2K4 inhibitor

Heparin is essential for optimal cell signaling by FGF21 and for regulation of βKlotho cellular stability

2022

Regulation of EGF-stimulated activation of the PI-3K/AKT pathway by exocyst-mediated exocytosis

Isoform-specific inhibition of FGFR signaling achieved by a de-novo-designed mini-protein

A hypothalamic pathway for Augmentor α–controlled body weight regulation

Design of protein-binding proteins from the target structure alone

2021

Structural basis for ligand reception by anaplastic lymphoma kinase

Mechanism for the activation of the anaplastic lymphoma kinase receptor

Integrated mutational landscape analysis of uterine leiomyosarcomas

2020

FGF23 contains two distinct high-affinity binding sites enabling bivalent interactions with α-Klotho

Scaffold association factor B (SAFB) is required for expression of prenyltransferases and RAS membrane association

Selective Janus Kinase 2 (JAK2) Pseudokinase Ligands with a Diaminotriazole Core

2019

Small molecule combats cancer-causing KRAS protein at last

Whole-exome sequencing of cervical carcinomas identifies activating ERBB2 and PIK3CA mutations as targets for combination therapy

Structures of ligand-occupied β-Klotho complexes reveal a molecular mechanism underlying endocrine FGF specificity and activity