Welcome to the Schlessinger Lab


We are interested in analyzing the mode of action of growth factor receptors and the intracellular signaling pathways that activated in response to growth factor stimulation. Receptor tyrosine kinases and cytoplasmic protein tyrosine kinases play a critical role in the control of many cellular processes including: cell proliferation, differentiation, m etabolism, as well as cell survival and cell migration. Various diseases are caused by dysfunctions in protein tyrosine kinases or in components of signaling pathways that are activated by these enzymes. We have used biochemical and genetic approaches as well as x-ray crystallography to determine the mechanism of activation of receptor tyrosine kinases and the mode of action of downstream signaling proteins.

About the Principal Investigator

Joseph Schlessinger has been the William H. Prusoff Professor and Chairman of the Department of Pharmacology at Yale University School of Medicine since 2001. 

Schlessinger Lab

Joseph Schlessinger, PhD

William H. Prusoff Professor of Pharmacology

Contact Info
Academic Office
Sterling Hall of Medicine, B-Wing
333 Cedar Street
New Haven, CT 06510