Cellular responses to FGF1 are modulated by palmitoylation of the docking protein FRS2α.
An S, Suzuki Y, Mohanty J, Tome F, Lax I, Schlessinger J. Cellular responses to FGF1 are modulated by palmitoylation of the docking protein FRS2α. Proceedings Of The National Academy Of Sciences Of The United States Of America 2026, 123: e2605311123. PMID: 42054356, PMCID: PMC13143043, DOI: 10.1073/pnas.2605311123.Peer-Reviewed Original Research
ConceptsDocking proteinMitogen-activated protein kinaseReceptor tyrosine kinasesPlasma membranePhosphorylation of multiple tyrosine residuesFormation of signaling complexesMultiple tyrosine residuesCellular responsesDownstream signaling moleculesMembrane rufflingExtracellular cuesPalmitoylation sitesFibroblast growth factorMultiprotein complexesSignaling ComplexTyrosine residuesProtein kinaseResponse to FGF1Ligand stimulationMAPK responsePalmitoylationTyrosine kinasePC12 cellsNeuronal differentiationCellular activities