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The Rimm Lab at Yale Pathology, under the direction of David Rimm, MD, PhD, Anthony N. Brady Professor of Pathology and professor of medicine (medical oncology), marks 30 years of research, innovation, and training.

Yale Cancer Center faculty and trainees joined 22,000 cancer researchers from around the world to share the latest advances in cancer science and medicine earlier this week in Chicago for the 116th American Association for Cancer Research (AACR) annual meeting. Dr. Patricia LoRusso, Amy and Joseph Perella Professor of Medicine at Yale Cancer Center and AACR President for 2024-25, shared her global view on cancer. “Cancer is a global disease—it spares no continent, no country. And each patient that gets the disease deserves treatment.”

Tumour-infiltrating lymphocytes (TILs) are crucial effectors of the anticancer immune response and are hypothesized to be key determinants the efficacy of immune-checkpoint inhibitors (ICIs). Herein, the authors review studies that have evaluated the roles of various TIL subsets as predictive biomarkers for ICIs, as well as opportunities, challenges and strategies for future research in this field.

Chen Liu, MD, PhD, Chair of Yale Pathology, welcomes public school students to the 2nd Annual Yale Pathology Day, where they explored careers in pathology.

More than half of human cancers, called “non-inflamed” or “cold” tumors, are not being effectively infiltrated by the cancer-fighting T cells. Essentially, the soldiers are excluded from the battlefield. Yale Cancer Center researchers want to know why.

The Yale Advanced Diagnostic Tests Laboratory in the Department of Pathology, a new unit of Yale Pathology Laboratories, offers access to novel molecular tests to external users, performing and interpreting clinical grade and high-quality molecular analysis of human tissue samples.

In this podcast, we’ll be covering the latest updates on immune checkpoint inhibitor resistance for patients with non-small cell lung cancer (NSCLC). We’ll be hearing from Professor Benjamin Besse, MD, Gustave Roussy Institute, Villejuif, France, Dr Kishu Ranjan, PhD, Yale School of Medicine, New Haven, CT, and Dr Biagio Ricciuti, MD, Dana-Farber Cancer Institute, Boston, MA, about new developments in our understanding of mechanisms of resistance, as well as possible therapeutic options for overcoming resistance.

Yale Cancer Center's Class of 1961 Cancer Research Awards were presented to Nikhil Joshi, PhD, and Kurt Schalper, MD, PhD, at the annual Yale Cancer Center Conclave on January 5, 2023.