Publications

Preclinical Ischemic Stroke Multicenter Trials (PRISM) Collective Statement: Opportunities, Challenges, and Recommendations for a New Era.Ayata C, Bath PM, Planas AM, Allan SM, Boltze J, Cabeen RP, Gibson CL, Cipolla MJ, Diniz MA, Fumagalli S, Hyder F, Koehler RC, Liesz A, McCann SK, Magnus T, McCullough LD, Sena ES, Beretta S, Aronowski J, Bosetti F, Wright CB, Lyden PD, Sansing LH. Stroke. 2026 Jan; 2025 Sep 11. PMID: 40931817.
Intracerebral haemorrhage laterality and associations with mood and pain: a MISTIE III substudy.Cooper DC, Abramson E, Ziai WC, Flaherty ML, Shah VA, Avadhani R, Ostapkovich N, Carhuapoma L, Awad I, Zuccarello M, Hanley D, Sansing LH. Stroke Vasc Neurol. 2025 Dec 23; 2025 Dec 23. PMID: 40250866.
Evaluating tocilizumab in ischemic stroke: Findings from the SPAN multicenter trial.Chauhan A, Lee EA, Patel RB, Kumskova M, Leira EC, Chauhan AK, Shi Y, Cao S, Koehler RC, Dhandapani KM, Khan MB, Kamat PK, Arbab A, Hess DC, Herman AL, Boisserand L, Sansing LH, Morais A, Jin X, Aykan S, Imai T, Ayata C, Nagarkatti KA, Lamb J, Diniz MA, Lyden PD, McCullough LD, Aronowski J. Neuropharmacology. 2025 Dec 5; 2025 Dec 5. PMID: 41354124.
Ryanodine receptor 2-mediated calcium leak is associated with increased glyoxalase I in the aging brain.Woo E, Datta D, Bathla S, Beatty H, Caglayan P, Albizu AK, Lam TT, Kanyo J, Joyce MK, Leslie S, Uchendu S, DeLong J, Guan QS, Li J, Abramson E, Herman AL, Cooper D, Licznerski P, Horvath TL, Jonas EA, Nairn AC, Arnsten AF, Sansing LH. JCI Insight. 2025 Nov 24; 2025 Oct 16. PMID: 41100182.
SLAMF1 as a Risk Biomarker for Nontraumatic SAH: Evidence From a Multiomics Study.Renedo D, Koo A, Sujijantarat N, Clocchiatti-Tuozzo S, Huo S, Acosta JN, Hebert R, Gunel M, Sansing L, Sheth KN, Falcone G, Matouk C, Rivier CA. Stroke. 2025 Nov 12; 2025 Nov 12. PMID: 41221640.
Fingolimod as a Potential Cerebroprotectant Results From the Stroke Preclinical Assessment Network.Boisserand LSB, Herman AL, Sanganahalli BG, Mihailovic J, Beatty HE, Johnson CW, Diaz S, DeLong JH, Velazquez S, Grutzendler J, Dela Cruz C, Zhou J, Sheth KN, Matouk C, Zhan S, Morais A, Imai T, Chauhan A, Patel RB, Kumskova M, Shi Y, Avery BD, Lamb J, Nagarkatti KA, Khan MB, Kamat PK, Dhandapani KM, McCullough LD, Aronowski J, Hess D, Koehler RC, Lyden P, Leira EC, Chauhan AK, Ayata C, Chen MH, Diniz MA, Hyder F, Sansing LH. Stroke. 2025 Nov; 2025 Sep 3. PMID: 40899256.
Multicenter Stroke Preclinical Assessment Network Analysis of Cardiovascular Risk Factor Subgroups Treated With the Poly(ADP-Ribose) Polymerase Inhibitor Veliparib.Koehler RC, Bedirian K, Chen MH, Shi Y, Cao S, Avery BD, Karuppagounder SS, Akhter K, Bibic A, Dawson VL, Dawson TM, Diniz MA, Lamb J, Nagarkatti KA, Chauhan A, Aronowski J, McCullough LD, de Morais AL, Jin X, Ayata C, Kumskova M, Patel RB, Chauhan AK, Leira EC, Kamat PK, Khan MB, Dhandapani KM, Hess DC, Boisserand LSB, Sanganahalli BG, Sansing LH, Lyden PD. J Am Heart Assoc. 2025 Oct 7; 2025 Sep 25. PMID: 40996065.
Operationalizing a complex acute clinical trial: Lessons from the BEACH study.Sorensen G, Remillard W, Schlechter M, Kampp M, Whisler Brady C, Kildahl K, Mould A, Ziai W, Lane K, Van Eldik LJ, Distasio A, Lu J, Sansing LH, Hanley DF, Magid-Bernstein J. J Clin Transl Sci. 2025; 2025 Sep 12. PMID: 41040632.
Clot Composition and Ischemic Stroke Etiology: A Contemporary Narrative Review.Kosyakovsky J, Rossitto CP, Antonios JP, Renedo D, Stapleton CJ, Sansing LH, Navaratnam DS, Giles JA, Patel AB, Matouk CC, Sujijantarat N. J Clin Med. 2025 Sep 2; 2025 Sep 2. PMID: 40943965.
Characterizing Stroke Clots Using Single-Cell Sequencing.Renedo D, Barak T, DeLong J, Acosta JN, Sujijantarat N, Koo A, Rivier CA, Clocchiatti-Tuozzo S, Huo S, Antonios J, Giles J, Falcone GJ, Sheth KN, Hebert R, Gunel M, Sansing LH, Navaratnam DS, Matouk C. J Am Heart Assoc. 2025 Sep 2; 2025 Aug 29. PMID: 40878981.
Early CSF inflammatory markers after aneurysmal subarachnoid hemorrhage and their relationship to disease severity and shunt placement.Magid-Bernstein J, Yan J, Herman AL, He Z, Johnson CW, Beatty H, Choi R, Velazquez S, Sorensen G, Jayasundara S, Grychowski L, Amllay A, Falcone GJ, Kim J, Petersen N, O'Keefe L, Gilmore EJ, Matouk C, Sheth KN, Sansing LH. J Stroke Cerebrovasc Dis. 2025 Sep; 2025 Jul 8. PMID: 40639751.
Determinants of Outcome After Endovascular Middle Cerebral Artery Occlusion in Rats in the SPAN Trial.Jin X, Morais A, Imai T, Lamb J, Nagarkatti K, Boisserand L, Beatty HE, Sansing LH, Khan MB, Dhandapani K, Kamat P, Hess DC, Patel RB, Kumskova M, Chauhan AK, McCullough LD, Aronowski J, Leira EC, Shi Y, Avery BD, Koehler RC, Lyden PD, Ayata C. Stroke. 2025 Sep; 2025 May 21. PMID: 40396268.
Multicenter SPAN Trial of Fasudil in Ischemic Stroke.Imai T, Morais AL, Jin X, Qin T, Lamb J, Nagarkatti KA, Chen MH, Boisserand LSB, Patel RB, Kumskova M, Chauhan A, Dhandapani KM, Khan MB, Kamat PK, Shi Y, Cao S, Sanganahalli BG, Mandeville JB, Lyden PD, Hess DC, Leira EC, Chauhan AK, Aronowski J, McCullough LD, Koehler RC, Sansing LH, Diniz MA, Ayata C. Stroke. 2025 Aug; 2025 May 27. PMID: 40421536.
The Ethnic/Racial Variations of Intracerebral Hemorrhage Genetics (ERICH-GENE) Study Protocol.Falcone GJ, Wolfe SQ, Zedde M, Pascarella R, Jimenez-Conde J, Vallverdu Prats M, Jimenez-Balado J, Pezzini A, Rossi S, Al-Shahi Salman R, Samarasekera N, Zand R, Li J, Jern C, Strbian D, Tomppo L, Sallinen H, Hernandez Guillamon M, Selim M, Owolabi M, Akinyemi R, Fakunle G, Lee TH, Werring D, Hostettler IC, Houlden H, Sharma P, John I, Ken-Dror G, Jenkins W, Sheth KN, Sansing LH, Sanghera DK, Sidorov E, Fernandez-Cadenas I, Cárcel-Márquez J, Chen CJ, Becerril-Gaitan A, Lee KJ, Bae HJ, Dichgans M, Malik R, Debette S, Mishra A, Pare G, Chong M, Kamatani Y, Chen Z, Walters RG, Seshadri S, Fornage M, Sudlow C, Gilkerson LA, Khandwala VJ, Maloney TC, Demel S, Parodi L, Zand R, Nyquist P, Ziai W, Worrall B, Achala VM, Langefeld CD, Rosand J, Anderson CD, Woo D. medRxiv. 2025 Jun 13; 2025 Jun 13. PMID: 40585153.
Elevated initial blood kynurenine is associated with increased odds of post-stroke infection: Kynurenine and post-stroke infection.Dylla L, Reisz JA, Poisson SN, Herson PS, Sansing LH, Monte AA. J Stroke Cerebrovasc Dis. 2025 May; 2025 Feb 25. PMID: 40015349.
Uric Acid Stroke Cerebroprotection Transcended Sex, Age, and Comorbidities in a Multicenter Preclinical Trial.Patel RB, Kumskova M, Kodali H, Budnik I, Kuznetsov V, Jain A, Jha A, Thedens D, Dhanesha N, Sutariya B, Nagarkatti KA, Lamb J, Kamat P, Shi Y, Avery B, Imai T, Jin X, Chauhan A, Boisserand LSB, Khan MB, Dhandapani K, Sanganahalli BG, Sansing LH, Hess DC, Koehler RC, McCullough LD, Aronowski J, Ayata C, Diniz MA, Lyden PD, Planas AM, Chamorro A, Chauhan AK, Leira EC. Stroke. 2025 Apr; 2025 Mar 17. PMID: 40091742.
Single-Cell Analysis in Cerebrovascular Research: Primed for Breakthroughs and Clinical Impact.Albertson AJ, Winkler EA, Yang AC, Buckwalter MS, Dingman AL, Fan H, Herson PS, McCullough LD, Perez-Pinzon MA, Sansing LH, Sun D, Alkayed NJ. Stroke. 2025 Apr; 2024 Dec 30. PMID: 39772596.
Operationalizing a complex acute clinical trial: Lessons from the BEACH study.Sorensen G, Remillard W, Schlechter M, Kampp M, Sansing LH, Brady CW, Kidahl K, Ziai W, Van Eldik L, Distasio A, Lu J, Magid-Bernstein J, Hanley D. medRxiv. 2025 Mar 31; 2025 Mar 31. PMID: 40236420.
The REpeated ASSEssment of SurvivorS in intracerebral haemorrhage: protocol for a multicentre, prospective observational study.Ziai W, Woo D, Sansing L, Hanley D, Ostapkovich N, Triene K, Gilkerson LA, Thompson R, Walborn N, Lane K, McBee N, Langefeld CD, Howard TD, Vagal A, Flaherty ML. BMJ Open. 2025 Feb 6; 2025 Feb 6. PMID: 39915023.
Sex Modifies the Severity and Outcome of Spontaneous Intracerebral Hemorrhage.Rivier CA, Renedo D, Marini S, Magid-Bernstein JR, de Havenon A, Rosand J, Hanley DF, Ziai WC, Mayer SA, Woo D, Sansing LH, Sheth KN, Anderson CD, Falcone GJ. Ann Neurol. 2025 Feb; 2024 Nov 5. PMID: 39499118.
Single-nucleus RNA sequencing of human periventricular white matter in vascular dementia.Díaz-Pérez S, DeLong JH, Rivier CA, Lee CY, Askenase MH, Zhu B, Zhang L, Brennand KJ, Martins AJ, Sansing LH. bioRxiv. 2024 Dec 10; 2024 Dec 10. PMID: 39713290.
Polygenic Risk of Epilepsy and Poststroke Epilepsy.Clocchiatti-Tuozzo S, Rivier CA, Misra S, Zelano J, Mazumder R, Sansing LH, de Havenon A, Hirsch LJ, Liebeskind DS, Gilmore EJ, Sheth KN, Kim JA, Worrall BB, Falcone GJ, Mishra NK. Stroke. 2024 Dec; 2024 Nov 6. PMID: 39502073.
Stroke Controversies and Debates: Imaging in Intracerebral Hemorrhage.Bower MM, Giles JA, Sansing LH, Carhuapoma JR, Woo D. Stroke. 2024 Nov; 2024 Oct 2. PMID: 39355925.
An Approach to Successful Development of Clinician-Scientists in Neurology: The NINDS R25 Experience.Josephson SA, Tennekoon MS, Carmichael ST, Cash SS, Detre JA, Hillis AE, Pennell PB, Pomeroy SL, Richerson GB, Sansing LH, Korn SJ. Ann Neurol. 2024 Oct; 2024 Aug 5. PMID: 39099460.
Biological and Procedural Predictors of Outcome in the Stroke Preclinical Assessment Network (SPAN) Trial.Morais A, Imai T, Jin X, Locascio JJ, Boisserand L, Herman AL, Chauhan A, Lamb J, Nagarkatti K, Diniz MA, Kumskova M, Dhanesha N, Kamat PK, Badruzzaman Khan M, Dhandapani KM, Patel RB, Sutariya B, Shi Y, van Leyen K, Kimberly WT, Hess DC, Aronowski J, Leira EC, Koehler RC, Chauhan AK, Sansing LH, Lyden PD, Ayata C. Circ Res. 2024 Aug 16; 2024 Jul 22. PMID: 39034919.
Deep learning for prediction of post-thrombectomy outcomes based on admission CT angiography in large vessel occlusion stroke.Sommer J, Dierksen F, Zeevi T, Tran AT, Avery EW, Mak A, Malhotra A, Matouk CC, Falcone GJ, Torres-Lopez V, Aneja S, Duncan J, Sansing LH, Sheth KN, Payabvash S. Front Artif Intell. 2024; 2024 Aug 1. PMID: 39149161.
Automated detection of early signs of irreversible ischemic change on CTA source images in patients with large vessel occlusion.Mak A, Matouk CC, Avery EW, Behland J, Haider SP, Frey D, Madai VI, Vajkoczy P, Griessenauer CJ, Zand R, Hendrix P, Abedi V, Sanelli PC, Falcone GJ, Petersen N, Sansing LH, Sheth KN, Payabvash S, Malhotra A. PLoS One. 2024; 2024 Jun 13. PMID: 38870240.
StrokeClassifier: ischemic stroke etiology classification by ensemble consensus modeling using electronic health records.Lee HJ, Schwamm LH, Sansing LH, Kamel H, de Havenon A, Turner AC, Sheth KN, Krishnaswamy S, Brandt C, Zhao H, Krumholz H, Sharma R. NPJ Digit Med. 2024 May 17; 2024 May 17. PMID: 38760474.
VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model.Boisserand LSB, Geraldo LH, Bouchart J, El Kamouh MR, Lee S, Sanganahalli BG, Spajer M, Zhang S, Lee S, Parent M, Xue Y, Skarica M, Yin X, Guegan J, Boyé K, Saceanu Leser F, Jacob L, Poulet M, Li M, Liu X, Velazquez SE, Singhabahu R, Robinson ME, Askenase MH, Osherov A, Sestan N, Zhou J, Alitalo K, Song E, Eichmann A, Sansing LH, Benveniste H, Hyder F, Thomas JL. J Exp Med. 2024 Apr 1; 2024 Mar 5. PMID: 38442272.
Clinical Trial Protocol for BEACH: A Phase 2a Study of MW189 in Patients with Acute Nontraumatic Intracerebral Hemorrhage.Avadhani R, Ziai WC, Thompson RE, Mould WA, Lane K, Nanni A, Iacobelli M, Sharrock MF, Sansing LH, Van Eldik LJ, Hanley DF. Neurocrit Care. 2024 Apr; 2023 Nov 2. PMID: 37919545.
Radiomics-Based Prediction of Collateral Status from CT Angiography of Patients Following a Large Vessel Occlusion Stroke.Avery EW, Abou-Karam A, Abi-Fadel S, Behland J, Mak A, Haider SP, Zeevi T, Sanelli PC, Filippi CG, Malhotra A, Matouk CC, Falcone GJ, Petersen N, Sansing LH, Sheth KN, Payabvash S. Diagnostics (Basel). 2024 Feb 23; 2024 Feb 23. PMID: 38472957.
Association of Neighborhood-Level Socioeconomic Factors With Delay to Hospital Arrival in Patients With Acute Stroke.Forman R, Okumu R, Mageid R, Baker A, Neu D, Parker R, Peyravi R, Schindler JL, Sansing LH, Sheth KN, de Havenon A, Jasne A, Narula R, Wira C, Warren J, Sharma R. Neurology. 2024 Jan 9; 2023 Dec 13. PMID: 38165368.
Characterization of CSF inflammatory markers after hemorrhagic stroke and their relationship to disease severity.Magid-Bernstein J, Yan J, Herman AL, He Z, Johnson CW, Beatty H, Choi R, Velazquez S, Neeman E, Falcone G, Kim J, Petersen N, Gilmore EJ, Matouk C, Sheth K, Sansing L. medRxiv. 2023 Dec 7; 2023 Dec 7. PMID: 38106157.
Trained immunity induced by high-salt diet impedes stroke recovery.Lin TY, Jiang D, Chen WR, Lin JS, Zhang XY, Chen CH, Hsu CL, Lai LC, Chen PH, Yang KC, Sansing LH, Chang CF. EMBO Rep. 2023 Dec 6; 2023 Nov 15. PMID: 37965920.
Common Pathways of Epileptogenesis in Patients With Epilepsy Post-Brain Injury: Findings From a Systematic Review and Meta-analysis.Misra S, Khan EI, Lam TT, Mazumder R, Gururangan K, Hickman LB, Goswami V, Funaro MC, Eldem E, Sansing LH, Sico JJ, Quinn TJ, Liebeskind DS, Montaner J, Kwan P, Mishra NK. Neurology. 2023 Nov 27; 2023 Nov 27. PMID: 37550071.
StrokeClassifier: Ischemic Stroke Etiology Classification by Ensemble Consensus Modeling Using Electronic Health Records.Lee HJ, Schwamm LH, Sansing L, Kamel H, de Havenon A, Turner AC, Sheth KN, Krishnaswamy S, Brandt C, Zhao H, Krumholz H, Sharma R. Res Sq. 2023 Oct 31; 2023 Oct 31. PMID: 37961532.
A multi-laboratory preclinical trial in rodents to assess treatment candidates for acute ischemic stroke.Lyden PD, Diniz MA, Bosetti F, Lamb J, Nagarkatti KA, Rogatko A, Kim S, Cabeen RP, Koenig JI, Akhter K, Arbab AS, Avery BD, Beatty HE, Bibic A, Cao S, Simoes Braga Boisserand L, Chamorro A, Chauhan A, Diaz-Perez S, Dhandapani K, Dhanesha N, Goh A, Herman AL, Hyder F, Imai T, Johnson CW, Khan MB, Kamat P, Karuppagounder SS, Kumskova M, Mihailovic JM, Mandeville JB, Morais A, Patel RB, Sanganahalli BG, Smith C, Shi Y, Sutariya B, Thedens D, Qin T, Velazquez SE, Aronowski J, Ayata C, Chauhan AK, Leira EC, Hess DC, Koehler RC, McCullough LD, Sansing LH. Sci Transl Med. 2023 Sep 20; 2023 Sep 20. PMID: 37729432.
Polygenic Risk of Epilepsy and Post-Stroke Epilepsy.Rivier CA, Clocchiatti-Tuozzo S, Misra S, Zelano J, Mazumder R, Sansing LH, de Havenon A, Hirsch LJ, Liebeskind DS, Gilmore EJ, Sheth KN, Kim JA, Worrall BB, Falcone G, Mishra NK. medRxiv. 2023 Sep 18; 2023 Sep 18. PMID: 37790357.
Radiomic markers of intracerebral hemorrhage expansion on non-contrast CT: independent validation and comparison with visual markers.Haider SP, Qureshi AI, Jain A, Tharmaseelan H, Berson ER, Zeevi T, Werring DJ, Gross M, Mak A, Malhotra A, Sansing LH, Falcone GJ, Sheth KN, Payabvash S. Front Neurosci. 2023; 2023 Aug 16. PMID: 37655013.
VEGF-C promotes brain-derived fluid drainage, confers neuroprotection, and improves stroke outcomes.Simoes Braga Boisserand L, Bouchart J, Geraldo LH, Lee S, Sanganahalli BG, Parent M, Zhang S, Xue Y, Skarica M, Guegan J, Li M, Liu X, Poulet M, Askanase M, Osherov A, Spajer M, Kamouh ME, Eichmann A, Alitalo K, Zhou J, Sestan N, Sansing LH, Benveniste H, Hyder F, Thomas JL. bioRxiv. 2023 May 30; 2023 May 30. PMID: 37398128.
Polygenic Susceptibility to Hypertension and Blood Pressure Control in Stroke Survivors.Acosta JN, Both CP, Demarais ZS, Conlon CJ, Leasure AC, Torres-Lopez VM, de Havenon A, Petersen NH, Gill TM, Sansing LH, Sheth KN, Falcone GJ. Neurology. 2023 Apr 11; 2023 Jan 23. PMID: 36690452.
Targeted drug delivery to the brain endothelium dominates over passive delivery via vascular leak in experimental intracerebral hemorrhage.Reyes-Esteves S, Nong J, Glassman PM, Omo-Lamai S, Ohashi S, Myerson JW, Zamora ME, Ma X, Kasner SE, Sansing L, Muzykantov VR, Marcos-Contreras OA, Brenner JS. J Control Release. 2023 Apr; 2023 Mar 7. PMID: 36868517.
Association of Soluble ST2 With Functional Outcome, Perihematomal Edema, and Immune Response After Intraparenchymal Hemorrhage.Bevers MB, Booraem C, Li K, Sreekrishnan A, Sastre C, Falcone GJ, Sheth KN, Sansing LH, Kimberly WT. Neurology. 2023 Mar 28; 2022 Dec 22. PMID: 36549913.
Technical Dissonance in Home Blood Pressure Monitoring After Stroke: Having the Machine, but Not Using Correctly.Forman R, Viscoli CM, Meurer K, Sheth KN, Sansing LH, de Havenon A, Sharma R, Mariscal M, Kernan WN. Am J Hypertens. 2023 Mar 15. PMID: 36520024.
Baseline Serum Biomarkers of Inflammation and Subsequent Visit-to-Visit Blood Pressure Variability: A Post Hoc Analysis of MESA.Wong KH, Muddasani V, Peterson C, Sheibani N, Arkin C, Cheong I, Majersik JJ, Biffi A, Petersen N, Falcone GJ, Sansing LH, de Havenon AH. Am J Hypertens. 2023 Feb 24. PMID: 36315490.
Embracing Heterogeneity in The Multicenter Stroke Preclinical Assessment Network (SPAN) Trial.Morais A, Locascio JJ, Sansing LH, Lamb J, Nagarkatti K, Imai T, van Leyen K, Aronowski J, Koenig JI, Bosetti F, Lyden P, Ayata C. Stroke. 2023 Feb; 2023 Jan 5. PMID: 36601951.
Role of Inflammatory Processes in Hemorrhagic Stroke.Ohashi SN, DeLong JH, Kozberg MG, Mazur-Hart DJ, van Veluw SJ, Alkayed NJ, Sansing LH. Stroke. 2023 Feb; 2023 Jan 5. PMID: 36601948.
Dataset on acute stroke risk stratification from CT angiographic radiomics.Avery EW, Behland J, Mak A, Haider SP, Zeevi T, Sanelli PC, Filippi CG, Malhotra A, Matouk CC, Griessenauer CJ, Zand R, Hendrix P, Abedi V, Falcone GJ, Petersen N, Sansing LH, Sheth KN, Payabvash S. Data Brief. 2022 Oct; 2022 Aug 14. PMID: 36060820.
Similar admission NIHSS may represent larger tissue-at-risk in patients with right-sided versus left-sided large vessel occlusion.Mak A, Matouk C, Avery EW, Behland J, Frey D, Madai VI, Vajkoczy P, Malhotra A, Abou Karam A, Sanelli P, Falcone GJ, Petersen NH, Sansing L, Sheth KN, Payabvash S. J Neurointerv Surg. 2022 Oct; 2021 Oct 13. PMID: 34645705.
Neuroimmune interactions in health and disease.Hafler DA, Sansing LH. Semin Immunopathol. 2022 Sep. PMID: 36171280.
Association of Chronic Kidney Disease With Risk of Intracerebral Hemorrhage.Vanent KN, Leasure AC, Acosta JN, Kuohn LR, Woo D, Murthy SB, Kamel H, Messé SR, Mullen MT, Cohen JB, Cohen DL, Townsend RR, Petersen NH, Sansing LH, Gill TM, Sheth KN, Falcone GJ. JAMA Neurol. 2022 Sep 1. PMID: 35969388.
Inflammatory Responses After Ischemic Stroke.DeLong JH, Ohashi SN, O'Connor KC, Sansing LH. Semin Immunopathol. 2022 Sep; 2022 Jun 29. PMID: 35767089.
The coronal plane maximum diameter of deep intracerebral hemorrhage predicts functional outcome more accurately than hematoma volume.Haider SP, Qureshi AI, Jain A, Tharmaseelan H, Berson ER, Majidi S, Filippi CG, Mak A, Werring DJ, Acosta JN, Malhotra A, Kim JA, Sansing LH, Falcone GJ, Sheth KN, Payabvash S. Int J Stroke. 2022 Aug; 2021 Oct 13. PMID: 34569877.
Association of lichen planus with cardiovascular disease: A combined analysis of the UK Biobank and All of Us Study.Leasure AC, Acosta JN, Sansing LH, Sheth KN, Cohen JM, Falcone GJ. J Am Acad Dermatol. 2022 Aug; 2021 Sep 22. PMID: 34562549.
Genetically-Proxied Levels of Vitamin D and Risk of Intracerebral Hemorrhage.Szejko N, Acosta JN, Both CP, Leasure A, Matouk C, Sansing L, Gill TM, Hongyu Z, Sheth K, Falcone GJ. J Am Heart Assoc. 2022 Jul 5; 2022 Jun 22. PMID: 35730641.
2022 Guideline for the Management of Patients With Spontaneous Intracerebral Hemorrhage: A Guideline From the American Heart Association/American Stroke Association.Greenberg SM, Ziai WC, Cordonnier C, Dowlatshahi D, Francis B, Goldstein JN, Hemphill JC 3rd, Johnson R, Keigher KM, Mack WJ, Mocco J, Newton EJ, Ruff IM, Sansing LH, Schulman S, Selim MH, Sheth KN, Sprigg N, Sunnerhagen KS. Stroke. 2022 Jul; 2022 May 17. PMID: 35579034.
Acute Ischemic Stroke, Depressed Left Ventricular Ejection Fraction, and Sinus Rhythm: Prevalence and Practice Patterns.Baker AD, Schwamm LH, Sanborn DY, Furie K, Stretz C, Mac Grory B, Yaghi S, Kleindorfer D, Sucharew H, Mackey J, Walsh K, Flaherty M, Kissela B, Alwell K, Khoury J, Khatri P, Adeoye O, Ferioli S, Woo D, Martini S, De Los Rios La Rosa F, Demel SL, Madsen T, Star M, Coleman E, Slavin S, Jasne A, Mistry EA, Haverbusch M, Merkler AE, Kamel H, Schindler J, Sansing LH, Faridi KF, Sugeng L, Sheth KN, Sharma R. Stroke. 2022 Jun; 2022 Jan 28. PMID: 35086361.
The Stroke Preclinical Assessment Network: Rationale, Design, Feasibility, and Stage 1 Results.Lyden PD, Bosetti F, Diniz MA, Rogatko A, Koenig JI, Lamb J, Nagarkatti KA, Cabeen RP, Hess DC, Kamat PK, Khan MB, Wood K, Dhandapani K, Arbab AS, Leira EC, Chauhan AK, Dhanesha N, Patel RB, Kumskova M, Thedens D, Morais A, Imai T, Qin T, Ayata C, Boisserand LSB, Herman AL, Beatty HE, Velazquez SE, Diaz-Perez S, Sanganahalli BG, Mihailovic JM, Hyder F, Sansing LH, Koehler RC, Lannon S, Shi Y, Karuppagounder SS, Bibic A, Akhter K, Aronowski J, McCullough LD, Chauhan A, Goh A. Stroke. 2022 May; 2022 Mar 31. PMID: 35354299.
Portable, low-field magnetic resonance imaging enables highly accessible and dynamic bedside evaluation of ischemic stroke.Yuen MM, Prabhat AM, Mazurek MH, Chavva IR, Crawford A, Cahn BA, Beekman R, Kim JA, Gobeske KT, Petersen NH, Falcone GJ, Gilmore EJ, Hwang DY, Jasne AS, Amin H, Sharma R, Matouk C, Ward A, Schindler J, Sansing L, de Havenon A, Aydin A, Wira C, Sze G, Rosen MS, Kimberly WT, Sheth KN. Sci Adv. 2022 Apr 22; 2022 Apr 20. PMID: 35442729.
Cerebral Hemorrhage: Pathophysiology, Treatment, and Future Directions.Magid-Bernstein J, Girard R, Polster S, Srinath A, Romanos S, Awad IA, Sansing LH. Circ Res. 2022 Apr 15; 2022 Apr 14. PMID: 35420918.
Maximizing Brain Health After Hemorrhagic Stroke: Bugher Foundation Centers of Excellence.Sheth KN, Anderson CD, Biffi A, Dlamini N, Falcone GJ, Fox CK, Fullerton HJ, Greenberg SM, Hemphill JC, Kim A, Kim H, Ko NU, Roland JL, Sansing LH, van Veluw SJ, Rosand J. Stroke. 2022 Mar; 2022 Feb 3. PMID: 35109678.
International Post Stroke Epilepsy Research Consortium (IPSERC): A consortium to accelerate discoveries in preventing epileptogenesis after stroke.Mishra NK, Engel J Jr, Liebeskind DS, Sharma VK, Hirsch LJ, Kasner SE, French JA, Devinsky O, Friedman A, Dawson J, Quinn TJ, Selim M, de Havenon A, Yasuda CL, Cendes F, Benninger F, Zaveri HP, Burneo JG, Srivastava P, Bhushan Singh M, Bhatia R, Vishnu VY, Bentes C, Ferro J, Weiss S, Sivaraju A, Kim JA, Galovic M, Gilmore EJ, Pitkänen A, Davis K, Sansing LH, Sheth KN, Paz JT, Singh A, Sheth S, Worrall BB, Grotta JC, Casillas-Espinos PM, Chen Z, Nicolo JP, Yan B, Kwan P. Epilepsy Behav. 2022 Feb; 2021 Dec 27. PMID: 34968775.
Bedside detection of intracranial midline shift using portable magnetic resonance imaging.Sheth KN, Yuen MM, Mazurek MH, Cahn BA, Prabhat AM, Salehi S, Shah JT, By S, Welch EB, Sofka M, Sacolick LI, Kim JA, Payabvash S, Falcone GJ, Gilmore EJ, Hwang DY, Matouk C, Gordon-Kundu B, Rn AW, Petersen N, Schindler J, Gobeske KT, Sansing LH, Sze G, Rosen MS, Kimberly WT, Kundu P. Sci Rep. 2022 Jan 7; 2022 Jan 7. PMID: 34996970.
CT angiographic radiomics signature for risk stratification in anterior large vessel occlusion stroke.Avery EW, Behland J, Mak A, Haider SP, Zeevi T, Sanelli PC, Filippi CG, Malhotra A, Matouk CC, Griessenauer CJ, Zand R, Hendrix P, Abedi V, Falcone GJ, Petersen N, Sansing LH, Sheth KN, Payabvash S. Neuroimage Clin. 2022; 2022 May 7. PMID: 35550243.
Prior Stroke and Age Predict Acute Ischemic Stroke Among Hospitalized COVID-19 Patients: A Derivation and Validation Study.Peng TJ, Jasne AS, Simonov M, Abdelhakim S, Kone G, Cheng YK, Rethana M, Tarasaria K, Herman AL, Baker AD, Yaghi S, Frontera JA, Sansing LH, Falcone GJ, Spudich S, Schindler J, Sheth KN, Sharma R. Front Neurol. 2021; 2021 Oct 4. PMID: 34675873.
Expedited and Comprehensive Management of Low-Risk TIA Patients in the Emergency Department is Safe and Less Costly.Garg A, Maran I, Amin H, Vlieks K, Neuschatz K, Coppola A, Poskus K, Johnson J, Davis M, Minja F, Schindler J, Sansing LH, Malhotra A, Jasne AS, Sharma R. J Stroke Cerebrovasc Dis. 2021 Oct; 2021 Jul 27. PMID: 34325273.
Intracerebral Hemorrhage with Intraventricular Extension Associated with Loss of Consciousness at Symptom Onset.Witsch J, Falcone GJ, Leasure AC, Matouk C, Endres M, Sansing L, Woo D, Sheth KN. Neurocrit Care. 2021 Oct; 2021 Jan 21. PMID: 33479920.
Cardiovascular Health Disparities in Racial and Other Underrepresented Groups: Initial Results From the All of Us Research Program.Acosta JN, Leasure AC, Both CP, Szejko N, Brown S, Torres-Lopez V, Abdelhakim S, Schindler J, Petersen N, Sansing L, Gill TM, Sheth KN, Falcone GJ. J Am Heart Assoc. 2021 Sep 7; 2021 Aug 25. PMID: 34431358.
Exogenous inter-α inhibitor proteins prevent cell death and improve ischemic stroke outcomes in mice.McCullough LD, Roy-O'Reilly M, Lai YJ, Patrizz A, Xu Y, Lee J, Holmes A, Kraushaar DC, Chauhan A, Sansing LH, Stonestreet BS, Zhu L, Kofler J, Lim YP, Venna VR. J Clin Invest. 2021 Sep 1. PMID: 34580244.
Admission computed tomography radiomic signatures outperform hematoma volume in predicting baseline clinical severity and functional outcome in the ATACH-2 trial intracerebral hemorrhage population.Haider SP, Qureshi AI, Jain A, Tharmaseelan H, Berson ER, Zeevi T, Majidi S, Filippi CG, Iseke S, Gross M, Acosta JN, Malhotra A, Kim JA, Sansing LH, Falcone GJ, Sheth KN, Payabvash S. Eur J Neurol. 2021 Sep; 2021 Jul 18. PMID: 34189814.
Chronic Stress Weakens Connectivity in the Prefrontal Cortex: Architectural and Molecular Changes.Woo E, Sansing LH, Arnsten AFT, Datta D. Chronic Stress (Thousand Oaks). 2021 Jan-Dec; 2021 Aug 29. PMID: 34485797.
Portable, bedside, low-field magnetic resonance imaging for evaluation of intracerebral hemorrhage.Mazurek MH, Cahn BA, Yuen MM, Prabhat AM, Chavva IR, Shah JT, Crawford AL, Welch EB, Rothberg J, Sacolick L, Poole M, Wira C, Matouk CC, Ward A, Timario N, Leasure A, Beekman R, Peng TJ, Witsch J, Antonios JP, Falcone GJ, Gobeske KT, Petersen N, Schindler J, Sansing L, Gilmore EJ, Hwang DY, Kim JA, Malhotra A, Sze G, Rosen MS, Kimberly WT, Sheth KN. Nat Commun. 2021 Aug 25; 2021 Aug 25. PMID: 34433813.
Early Inflammatory Cytokine Expression in Cerebrospinal Fluid of Patients with Spontaneous Intraventricular Hemorrhage.Ziai WC, Parry-Jones AR, Thompson CB, Sansing LH, Mullen MT, Murthy SB, Mould A, Nekoovaght-Tak S, Hanley DF. Biomolecules. 2021 Jul 30; 2021 Jul 30. PMID: 34439789.
Intracerebral Hemorrhage in Patients With COVID-19: An Analysis From the COVID-19 Cardiovascular Disease Registry.Leasure AC, Khan YM, Iyer R, Elkind MSV, Sansing LH, Falcone GJ, Sheth KN. Stroke. 2021 Jul; 2021 Jun 4. PMID: 34082576.
Direct carotid puncture for mechanical thrombectomy in acute ischemic stroke patients with prohibitive vascular access.Cord BJ, Kodali S, Strander S, Silverman A, Wang A, Chouairi F, Koo AB, Nguyen CK, Peshwe K, Kimmel A, Porto CM, Hebert RM, Falcone GJ, Sheth KN, Sansing LH, Schindler JL, Matouk CC, Petersen NH. J Neurosurg. 2021 Jul 1; 2020 Aug 14. PMID: 32796146.
Ischemic Stroke, Inflammation, and Endotheliopathy in COVID-19 Patients.McAlpine LS, Zubair AS, Maran I, Chojecka P, Lleva P, Jasne AS, Navaratnam D, Matouk C, Schindler J, Sheth KN, Chun H, Lee AI, Spudich S, Sharma R, Sansing LH. Stroke. 2021 Jun; 2021 May 10. PMID: 33966492.
Divergent Functions of Tissue-Resident and Blood-Derived Macrophages in the Hemorrhagic Brain.Chang CF, Goods BA, Askenase MH, Beatty HE, Osherov A, DeLong JH, Hammond MD, Massey J, Landreneau M, Love JC, Sansing LH. Stroke. 2021 May; 2021 Apr 12. PMID: 33840225.
Endothelial cell secreted VEGF-C enhances NSC VEGFR3 expression and promotes NSC survival.Matta R, Feng Y, Sansing LH, Gonzalez AL. Stem Cell Res. 2021 May; 2021 Apr 1. PMID: 33836422.
Obstructive Sleep Apnea as a Risk Factor for Intracerebral Hemorrhage.Geer JH, Falcone GJ, Vanent KN, Leasure AC, Woo D, Molano JR, Sansing LH, Langefeld CD, Pisani MA, Yaggi HK, Sheth KN. Stroke. 2021 May; 2021 Apr 8. PMID: 33827242.
Association of Serum IL-6 (Interleukin 6) With Functional Outcome After Intracerebral Hemorrhage.Leasure AC, Kuohn LR, Vanent KN, Bevers MB, Kimberly WT, Steiner T, Mayer SA, Matouk CC, Sansing LH, Falcone GJ, Sheth KN. Stroke. 2021 May; 2021 Mar 8. PMID: 33682454.
Admission Hemoglobin Levels Are Associated With Functional Outcome in Spontaneous Intracerebral Hemorrhage.Acosta JN, Leasure AC, Kuohn LR, Both CP, Petersen NH, Sansing LH, Matouk CC, Testai F, Langefeld CD, Woo D, Kamel H, Murthy SB, Qureshi A, Mayer SA, Sheth KN, Falcone GJ. Crit Care Med. 2021 May 1. PMID: 33591003.
Leukocyte dynamics after intracerebral hemorrhage in a living patient reveal rapid adaptations to tissue milieu.Goods BA, Askenase MH, Markarian E, Beatty HE, Drake RS, Fleming I, DeLong JH, Philip NH, Matouk CC, Awad IA, Zuccarello M, Hanley DF, Love JC, Shalek AK, Sansing LH. JCI Insight. 2021 Mar 22; 2021 Mar 22. PMID: 33749664.
Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage.Askenase MH, Goods BA, Beatty HE, Steinschneider AF, Velazquez SE, Osherov A, Landreneau MJ, Carroll SL, Tran TB, Avram VS, Drake RS, Gatter GJ, Massey JA, Karuppagounder SS, Ratan RR, Matouk CC, Sheth KN, Ziai WC, Parry-Jones AR, Awad IA, Zuccarello M, Thompson RE, Dawson J, Hanley DF, Love JC, Shalek AK, Sansing LH. Sci Immunol. 2021 Feb 19; 2021 Feb 19. PMID: 33891558.
New Mechanistic Insights, Novel Treatment Paradigms, and Clinical Progress in Cerebrovascular Diseases.Boltze J, Aronowski JA, Badaut J, Buckwalter MS, Caleo M, Chopp M, Dave KR, Didwischus N, Dijkhuizen RM, Doeppner TR, Dreier JP, Fouad K, Gelderblom M, Gertz K, Golubczyk D, Gregson BA, Hamel E, Hanley DF, Härtig W, Hummel FC, Ikhsan M, Janowski M, Jolkkonen J, Karuppagounder SS, Keep RF, Koerte IK, Kokaia Z, Li P, Liu F, Lizasoain I, Ludewig P, Metz GAS, Montagne A, Obenaus A, Palumbo A, Pearl M, Perez-Pinzon M, Planas AM, Plesnila N, Raval AP, Rueger MA, Sansing LH, Sohrabji F, Stagg CJ, Stetler RA, Stowe AM, Sun D, Taguchi A, Tanter M, Vay SU, Vemuganti R, Vivien D, Walczak P, Wang J, Xiong Y, Zille M. Front Aging Neurosci. 2021; 2021 Jan 28. PMID: 33584250.
Excess Cerebrovascular Mortality in the United States During the COVID-19 Pandemic.Sharma R, Kuohn LR, Weinberger DM, Warren JL, Sansing LH, Jasne A, Falcone G, Dhand A, Sheth KN. Stroke. 2021 Jan; 2021 Jan 12. PMID: 33430638.
Cause of death in spontaneous intracerebral hemorrhage survivors: Multistate longitudinal study.Kuohn LR, Leasure AC, Acosta JN, Vanent K, Murthy SB, Kamel H, Matouk CC, Sansing LH, Falcone GJ, Sheth KN. Neurology. 2020 Nov 17; 2020 Sep 11. PMID: 32917797.
Plasma neurofilament light predicts mortality in patients with stroke.Gendron TF, Badi MK, Heckman MG, Jansen-West KR, Vilanilam GK, Johnson PW, Burch AR, Walton RL, Ross OA, Brott TG, Miller TM, Berry JD, Nicholson KA, Wszolek ZK, Oskarsson BE, Sheth KN, Sansing LH, Falcone GJ, Cucchiara BL, Meschia JF, Petrucelli L. Sci Transl Med. 2020 Nov 11. PMID: 33177179.
Assessment of Brain Injury Using Portable, Low-Field Magnetic Resonance Imaging at the Bedside of Critically Ill Patients.Sheth KN, Mazurek MH, Yuen MM, Cahn BA, Shah JT, Ward A, Kim JA, Gilmore EJ, Falcone GJ, Petersen N, Gobeske KT, Kaddouh F, Hwang DY, Schindler J, Sansing L, Matouk C, Rothberg J, Sze G, Siner J, Rosen MS, Spudich S, Kimberly WT. JAMA Neurol. 2020 Sep 8; 2020 Sep 8. PMID: 32897296.
Effects of Collateral Status on Infarct Distribution Following Endovascular Therapy in Large Vessel Occlusion Stroke.Al-Dasuqi K, Payabvash S, Torres-Flores GA, Strander SM, Nguyen CK, Peshwe KU, Kodali S, Silverman A, Malhotra A, Johnson MH, Matouk CC, Schindler JL, Sansing LH, Falcone GJ, Sheth KN, Petersen NH. Stroke. 2020 Sep; 2020 Aug 12. PMID: 32781941.
Stroke Code Presentations, Interventions, and Outcomes Before and During the COVID-19 Pandemic.Jasne AS, Chojecka P, Maran I, Mageid R, Eldokmak M, Zhang Q, Nystrom K, Vlieks K, Askenase M, Petersen N, Falcone GJ, Wira CR 3rd, Lleva P, Zeevi N, Narula R, Amin H, Navaratnam D, Loomis C, Hwang DY, Schindler J, Hebert R, Matouk C, Krumholz HM, Spudich S, Sheth KN, Sansing LH, Sharma R. Stroke. 2020 Sep; 2020 Jul 31. PMID: 32755347.
Preserving stroke care during the COVID-19 pandemic: Potential issues and solutions.Leira EC, Russman AN, Biller J, Brown DL, Bushnell CD, Caso V, Chamorro A, Creutzfeldt CJ, Cruz-Flores S, Elkind MSV, Fayad P, Froehler MT, Goldstein LB, Gonzales NR, Kaskie B, Khatri P, Livesay S, Liebeskind DS, Majersik JJ, Moheet AM, Romano JG, Sanossian N, Sansing LH, Silver B, Simpkins AN, Smith W, Tirschwell DL, Wang DZ, Yavagal DR, Worrall BB. Neurology. 2020 Jul 21; 2020 May 8. PMID: 32385186.
Genetically Elevated LDL Associates with Lower Risk of Intracerebral Hemorrhage.Falcone GJ, Kirsch E, Acosta JN, Noche RB, Leasure A, Marini S, Chung J, Selim M, Meschia JF, Brown DL, Worrall BB, Tirschwell DL, Jagiella JM, Schmidt H, Jimenez-Conde J, Fernandez-Cadenas I, Lindgren A, Slowik A, Gill D, Holmes M, Phuah CL, Petersen NH, Matouk Md CN, Gunel M, Sansing L, Bennett D, Chen Z, Sun LL, Clarke R, Walters RG, Gill TM, Biffi A, Kathiresan S, Langefeld CD, Woo D, Rosand J, Sheth KN, Anderson CD. Ann Neurol. 2020 Jul; 2020 May 7. PMID: 32277781.
Response by Chang and Sansing to Letter Regarding Article, "Bexarotene Enhances Macrophage Erythrophagocytosis and Hematoma Clearance in Experimental Intracerebral Hemorrhage".Chang CF, Sansing LH. Stroke. 2020 May; 2020 Apr 17. PMID: 32299318.
Depletion of CD4 T cells provides therapeutic benefits in aged mice after ischemic stroke.Harris NM, Roy-O'Reilly M, Ritzel RM, Holmes A, Sansing LH, O'Keefe LM, McCullough LD, Chauhan A. Exp Neurol. 2020 Apr; 2020 Jan 15. PMID: 31954116.
Fixed Compared With Autoregulation-Oriented Blood Pressure Thresholds After Mechanical Thrombectomy for Ischemic Stroke.Petersen NH, Silverman A, Strander SM, Kodali S, Wang A, Sansing LH, Schindler JL, Falcone GJ, Gilmore EJ, Jasne AS, Cord B, Hebert RM, Johnson M, Matouk CC, Sheth KN. Stroke. 2020 Mar; 2020 Feb 12. PMID: 32078493.
Bexarotene Enhances Macrophage Erythrophagocytosis and Hematoma Clearance in Experimental Intracerebral Hemorrhage.Chang CF, Massey J, Osherov A, Angenendt da Costa LH, Sansing LH. Stroke. 2020 Feb; 2019 Dec 12. PMID: 31826730.
Racial/ethnic disparities in the risk of intracerebral hemorrhage recurrence.Leasure AC, King ZA, Torres-Lopez V, Murthy SB, Kamel H, Shoamanesh A, Al-Shahi Salman R, Rosand J, Ziai WC, Hanley DF, Woo D, Matouk CC, Sansing LH, Falcone GJ, Sheth KN. Neurology. 2020 Jan 21; 2019 Dec 12. PMID: 31831597.
Aging exacerbates neutrophil pathogenicity in ischemic stroke.Roy-O'Reilly MA, Ahnstedt H, Spychala MS, Munshi Y, Aronowski J, Sansing LH, McCullough LD. Aging (Albany NY). 2020 Jan 12; 2020 Jan 12. PMID: 31927534.
Perihematomal Edema After Intracerebral Hemorrhage in Patients With Active Malignancy.Gusdon AM, Nyquist PA, Torres-Lopez VM, Leasure AC, Falcone GJ, Sheth KN, Sansing LH, Hanley DF, Malani R. Stroke. 2020 Jan; 2019 Nov 20. PMID: 31744426.
Antiplatelet Therapy After Spontaneous Intracerebral Hemorrhage and Functional Outcomes.Murthy SB, Biffi A, Falcone GJ, Sansing LH, Torres Lopez V, Navi BB, Roh DJ, Mandava P, Hanley DF, Ziai WC, Kamel H, Rosand J, Sheth KN. Stroke. 2019 Nov; 2019 Sep 20. PMID: 31895618.