Jonathan Howard DeLong, PhD

Jonathan completed his PhD in the lab of Dr. Chris Hunter at the University of Pennsylvania. His thesis work helped establish the cytokine IL-27 as a critical driver of inhibitory receptor expression, important in limiting T cell-mediated immunopathology as well as limiting productive anti-tumor responses.

In the Sansing lab, he is studying the endogenous signals that control inflammation and wound healing following hemorrhagic stroke. One major focus is on the immunomodulatory effects of cholesterol. Previous studies have demonstrated compelling effects of cholesterol on the macrophage response to LPS. Jonathan aims to expand on these observations, developing a broader model to understand the roles of cholesterol uptake in macrophage function, with a focus on sterile inflammation.