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Papers Recently Presented

  • Kazmier, K., S. Sharma, M. Quick, S. M. Islam, B. Roux, H. Weinstein, J. A. Javitch and H. S. McHaourab (2014). "Conformational dynamics of ligand-dependent alternating access in LeuT." Nat Struct Mol Biol21(5): 472-479.
  • Felts B, Pramod AB, Sandtner W, Burbach N, Bulling S, Sitte HH, Henry LK (2014) The two Na+ sites in the human serotonin transporter play distinct roles in the ion coupling and electrogenicity of transport. J Biol Chem 289 (3):1825-1840
  • Akyuz N, Altman RB, Blanchard SC, Boudker O. Transport dynamics in a glutamate transporter homologue. Nature. 2013 Epub
  • Ben-Yona A, Kanner BI. Functional defects in the external and internal thin gates of the γ-aminobutyric acid (GABA) transporter GAT-1 can compensate each other. J Biol Chem. 2013 Feb 15;288(7):4549-56
  • Herzig, H, Raemy, E, Montessuit, S, Veuthey, J-L, Zamboni, N, Westermann, B, Kunji, ERS and Martinou, J-C Identification and Functional Expression of the Mitochondrial Pyruvate Carrier.Science 337: 93-96 (2012)
  • Bricker, DK, Taylor, EB, Schell, JC, Orsak, T, Boutron, A, Chen, Y-C, Cox, JE, Cardon, CM, Van Vranken, JG, Dephoure, N, Redin, C, Boudina, S, Gygi, SP, Brivet, M, Thummel, CS, and Rutter, J A Mitochondrial Pyruvate Carrier Required for Pyruvate Uptake in Yeast, Drosophila, and Humans Science 337: 96-100 (2012)
  • Rao, A., Richards, T. L., Simmons, D., Zahniser, N. R., Sorkin, A. Epitope-tagged dopamine transporter knock-in mice reveal rapid endocytic trafficking and filopodia targeting of the transporter in dopaminergic axons. FASEB J. 26, 1921-1933 (2012)
  • Moritz AE, Foster JD, Gorentla BK, Mazei-Robison MS, Yang JW, Sitte HH, Blakely RD, Vaughan RA. (2012) Phosphorylation of Dopamine Transporter Serine 7 Modulates Cocaine Analog Binding. J Biol Chem. Nov 16. [Epub ahead of print]
  • James D. Foster,Jae-Won Yang,Amy E. Moritz, Sathyavathi ChallaSivaKanaka, Margaret A. Smith, Marion Holy, Kyle Wilebski, Harald H. Sitte, Roxanne A. Vaughan (2012) Dopamine transporter phosphorylation site threonine 53 regulates substrate reuptake and amphetamine-stimulated efflux.J Biol Chem. 287(35):29702-12
  • Per Plenge, Lei Shi, Thijs Beuming, Jerez Te, Amy Hauck Newman, Harel Weinstein, Ulrik Gether and Claus J. Loland (2012) Steric hindrance mutagenesis in the conserved extracellular vestibule impedes allosteric binding of antidepressants to the serotonin transporter.J Biol Chem. 287(47):39316-26
  • Thomas Steinkellner, Jae-Won Yang, Therese R. Montgomery, Wei-Qiang Chen, Marie-Therese Winkler, Sonja Sucic, Gert Lubec, Michael Freissmuth, Ype Elgersma, Harald H. Sitte, and Oliver Kudlacek (2012) αCaMKII controls the activity of the dopamine transporter: implications for Angelman syndromeJ Biol Chem. 287(35):29627-35
  • Dhananjay Sakrikar, Michelle S. Mazei-Robison, Marc A. Mergy, Nathan W. Richtand, Qiao Han, Peter J. Hamilton,
    Erica Bowton, Aurelio Galli, Jeremy Veenstra-VanderWeele, Michael Gill, and Randy D. Blakely (2012) Attention Deficit/Hyperactivity Disorder-Derived Coding Variation in the Dopamine Transporter Disrupts Microdomain Targeting and Trafficking Regulation. The Journal of Neuroscience, 32(16):5385–5397
  • Assaf Ben-Yona and Baruch I. Kanner (2012) An Acidic Amino Acid Transmembrane Helix 10 Residue Conserved in the Neurotransmitter:Sodium:Symporters is Essential for the Formation of the Extracellular Gate of the gamma-Aminobutyric Acid (GABA) Transporter GAT-1. J. Biol Chem 287 (10): 7159–7168
  • Focke PJ, Moenne-Loccoz P, Larsson HP (2011) Opposite movement of the external gate of a glutamate transporter homolog upon binding cotransported sodium compared with substrate. J Neurosci. Apr 20;31(16):6255-62.
  • Jun Liao, Hua Li, Weizhong Zeng, David B. Sauer, Ricardo Belmares and Youxing Jiang(2012) Structural Insight into the Ion-Exchange Mechanism of the Sodium/Calcium ExchangerScience10 February 2012:686-690
  • Ernesto Solís, Jr., Igor Zdravkovic, Ian D. Tomlinson, Sergei Y. Noskov, Sandra J. Rosenthal, Louis J. De Felice (2012) 4-(4-(Dimethylamino)phenyl)-1-methylpyridinium (app+) is a Fluorescent Substrate for the Human Serotonin Transporter. JBC http://www.jbc.org/cgi/doi/10.1074/jbc.M111.267757
  • Wang H, Elferich J, Gouaux E.(2012) Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context. Nat Struct Mol Biol. Jan 15;19(2):212-9
  • Krishnamurthy H, Gouaux E. (2012) X-ray structures of LeuT in substrate-free outward-open and apo inward-open states. Nature. 2012 Jan 9. doi: 10.1038/nature10737. [Epub ahead of print]
  • Monika Paroder-Belenitsky,Matthew J. Maestas, Orsolya Dohán,Juan Pablo Nicola,Andrea Reyna-Neyra,Antonia Follenzi,Ekaterina Dadachova,Sepehr Eskandari,L. Mario Amzel andNancy Carrasco. (2011)Mechanism of anion selectivity and stoichiometry of the Na+/I- symporter (NIS)PNASNovember 1, 2011vol. 108no. 4417933-17938
  • Balasubramaniam Annamalai, Padmanabhan Mannangatti, Obulakshmi Arapulisamy, Toni S. Shippenberg, Lankupalle D. Jayanthi and Sammanda Ramamoorthy, (2011) Tyrosine Phosphorylation of the Human Serotonin Transporter: A Role in the Transporter Stability and Function Molecular Pharmacology Fast Forward. Published on October 12, 2011 as doi:10.1124/mol.111.073171
  • Sucic S, El-Kasaby A, Kudlacek O, Sarker S, Sitte HH, Marin P, Freissmuth M (2011) The serotonin transporter is an exclusive client of the coat protein complex II (COPII) component SEC24C. J Biol Chem. 286: 16482-90
  • Chong-Bin Zhu, Kathryn M. Lindler, Nicholas G. Campbell, James S. Sutcliffe, William A. Hewlett, and Randy D. Blakely (2011) Colocalization and Regulated Physical Association of Presynaptic Serotonin Transporters with A3 Adenosine Receptors Mol Pharmacol 80: 458–465
  • Foster JD, Vaughan RA. (2011) Palmitoylation controls dopamine transporter kinetics, degradation, and protein kinase C-dependent regulation. J Biol Chem. 286(7): 5175-86.
  • JacobAndersen, Nicolai Stuhr-Hansen, Linda Zachariassen, Søren Toubro, Stinna M. R. Hansen, Jonas N. N. Eildal, Andrew D. Bond, Klaus P. Bøgesø, Benny Bang-Andersen, Anders S. Kristensen, and Kristian Strømgaard (2011) Molecular determinants for selective recognition of antidepressants in the human serotonin and norepinephrine transportersPNAS108(29)12137-12142
  • Cocaine Up-regulation of the Norepinephrine Transporter Requires Threonine 30 Phosphorylation by p38 Mitogen-activated Protein Kinase. Padmanabhan Mannangatti, Obulakshmi Arapulisamy, Toni S . Shippenberg, Sammanda Ramamoorthy and Lankupalle D. Jayanthi JBC 286 (23): 20239-50 (2011)
  • Dopamine Transport by the Serotonin Transporter: A Mechanistically Distinct Mode of Substrate Translocation Mads Breum Larsen, Mark S. Sonders, Ole Valente Mortensen, Gaynor A. Larson, Nancy R. Zahniser, and Susan G. Amara The Journal of Neuroscience, April 27, 2011 • 31(17):6605– 6615
  • Structure and mechanism of the uracil transporter UraA. Lu F, Li S, Jiang Y, Jiang J, Fan H, Lu G, Deng D, Dang S, Zhang X, Wang J, Yan N.Nature. 2011 Apr 14;472(7342):243-6. Epub 2011 Mar 20.
  • Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue. Zhao Y, Terry DS, Shi L, Quick M, Weinstein H, Blanchard SC, Javitch JA. Nature. 2011 Jun 2;474(7349):109-13
  • Structural analysis of the extracellular entrance to the serotonin transporter permeation pathway. Torres-Altoro MI, Kuntz CP, Nichols DE, Barker EL. J Biol Chem. 2010 May 14;285(20):15369-79.