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Light microscopy is traditionally limited by diffraction to about 250 nm resolution in the focal plane and more than 500 nm in depth. Super-resolution STED microscopy has overcome this diffraction limit but achieving sub-100 nm super-resolution in 3D in the middle of a tissue section has been impossible due to the optical aberrations the tissue introduces into the optical beam path. Introducing adaptive optics into an isoSTED microscope, an instrument that utilizes two opposing objectives for optimal 3D resolution, allowed the authors to correct for these aberrations. Using this instrument, they were able to obtain for the first time multi-color sub-50 nm 3D resolution images in samples as complex as Drosophila egg chambers and mouse brain tissue sections.

The Kavli and Nobel Prize Laureate on his groundbreaking work finding out how our bodies ship vital molecules to where they are needed — enabling profound advances in medicine.

James E. Rothman, newly appointed as a Sterling Professor of Cell Biology, is one of the world's most distinguished biochemists and cell biologists. For his work on how molecular messages are transmitted inside and outside of human cells, he was awarded a Nobel Prize in 2013.

James E. Rothman, ’71 B.S., the Fergus F. Wallace Professor of Biomedical Sciences, and professor and chair of the Department of Cell Biology at Yale University, was awarded the 2013 Nobel Prize in Physiology or Medicine for his work on how molecular messages are transmitted inside and outside of our cells, the Royal Swedish National Academy announced today (Oct.7).

Yale cell biologist James E. Rothman today has been named one of three recipients awarded the 2010 Kavli Prize in Neuroscience, the second consecutive time a Yale scientist has been a co-recipient of the prestigious, biennial $1 million prize.

James E. Rothman, the newly designated Fergus F. Wallace Professor of Biomedical Sciences, is an internationally renowned expert on membrane trafficking, the means by which proteins and other materials are transported within and between cells.