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Imaging tissue samples at sub-50 nm resolution in 3D by light microscopy

Light microscopy is traditionally limited by diffraction to about 250 nm resolution in the focal plane and more than 500 nm in depth. Super-resolution STED microscopy has overcome this diffraction limit but achieving sub-100 nm super-resolution in 3D in the middle of a tissue section has been impossible due to the optical aberrations the tissue introduces into the optical beam path. Introducing adaptive optics into an isoSTED microscope, an instrument that utilizes two opposing objectives for optimal 3D resolution, allowed the authors to correct for these aberrations. Using this instrument, they were able to obtain for the first time multi-color sub-50 nm 3D resolution images in samples as complex as Drosophila egg chambers and mouse brain tissue sections.

Source: Nature Methods
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  • James Rothman appointed Sterling Professor of Cell Biology

    James E. Rothman, newly appointed as a Sterling Professor of Cell Biology, is one of the world's most distinguished biochemists and cell biologists. For his work on how molecular messages are transmitted inside and outside of human cells, he was awarded a Nobel Prize in 2013.

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  • Yale’s James Rothman shares 2013 Nobel Prize in Physiology or Medicine

    James E. Rothman, ’71 B.S., the Fergus F. Wallace Professor of Biomedical Sciences, and professor and chair of the Department of Cell Biology at Yale University, was awarded the 2013 Nobel Prize in Physiology or Medicine for his work on how molecular messages are transmitted inside and outside of our cells, the Royal Swedish National Academy announced today (Oct.7).

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  • BBS cell biologist is honored with two awards

    James E. Rothman, Ph.D., the Fergus F. Wallace Professor of Biomedical Sciences and chair of the Department of Cell Biology, has been awarded both the E.B. Wilson Medal and the Massry Prize for his seminal contributions to the field of cell biology.

    Source: Medicine@Yale
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  • Yale’s Rothman Wins 2010 Kavli Prize for Neuroscience

    Yale cell biologist James E. Rothman today has been named one of three recipients awarded the 2010 Kavli Prize in Neuroscience, the second consecutive time a Yale scientist has been a co-recipient of the prestigious, biennial $1 million prize.

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  • Leading Scientist Named New Chair of Cell Biology at Yale

    Yale University announced today the appointment of James E. Rothman, one of the world's leading cell biologists, as chair of Yale School of Medicine's Department of Cell Biology. Additionally, Rothman will launch the Center for High-Throughput Cell Biology at Yale's West Campus, formerly the site of Bayer Pharmaceuticals.

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