2013
Methamphetamine-induced increases in putamen gray matter associate with inhibitory control
Groman SM, Morales AM, Lee B, London ED, Jentsch JD. Methamphetamine-induced increases in putamen gray matter associate with inhibitory control. Psychopharmacology 2013, 229: 527-538. PMID: 23748383, PMCID: PMC3770792, DOI: 10.1007/s00213-013-3159-9.Peer-Reviewed Original ResearchMeSH KeywordsAmphetamine-Related DisordersAnimalsChlorocebus aethiopsCognitionDiscrimination, PsychologicalDose-Response Relationship, DrugInhibition, PsychologicalMagnetic Resonance ImagingMaleMethamphetaminePositron-Emission TomographyPutamenReceptors, Dopamine D2Retention, PsychologyReversal LearningTime FactorsConceptsD2-like receptorsGray matterDrug usePositron emission tomography scanDopamine D2-like receptorsDrug-experienced individualsHuman methamphetamine usersRegimen of methamphetamineEmission tomography scanGray matter abnormalitiesMethamphetamine-induced increasesDrug-induced changesInhibitory controlNeurobiological risk factorsDopaminergic markersRisk factorsTomography scanDAT availabilityRight putamenTransporter availabilityPharmacological effectsStructural abnormalitiesRegimenMagnetic resonance imagesObjectivesThe purposeIdentifying the molecular basis of inhibitory control deficits in addictions: neuroimaging in non-human primates
Groman SM, Jentsch JD. Identifying the molecular basis of inhibitory control deficits in addictions: neuroimaging in non-human primates. Current Opinion In Neurobiology 2013, 23: 625-631. PMID: 23528268, PMCID: PMC3731407, DOI: 10.1016/j.conb.2013.03.001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AddictiveDopamineHumansInhibition, PsychologicalNeuroimagingSubstance-Related DisordersConceptsNon-human primatesSerotonin systemStimulant-dependent individualsAddiction-related behaviorsInhibitory control deficitsTreatment of addictionDopamine systemNeural alterationsAddiction liabilityNovel targetStimulant useStimulant addictionFunctional phenotypeControl deficitsHuman primatesRecent dataInhibitory controlAddictionBi-directional relationshipBiological phenotypesPrimatesPhenotype
2011
Cognitive control and the dopamine D2‐like receptor: a dimensional understanding of addiction
Groman SM, Jentsch JD. Cognitive control and the dopamine D2‐like receptor: a dimensional understanding of addiction. Depression And Anxiety 2011, 29: 295-306. PMID: 22147558, DOI: 10.1002/da.20897.Peer-Reviewed Original ResearchMeSH KeywordsBehavior, AddictiveBiomarkersDopamineHumansImpulsive BehaviorInhibition, PsychologicalMental DisordersReceptors, Dopamine D2ConceptsCognitive controlCognitive control abilitiesSubstantial psychosocial impairmentCognitive processesPsychosocial impairmentDimensional understandingCognitive dysfunctionControl abilityCategorical diagnosesPsychiatric conditionsParticular dimensionAddictionPsychiatric disordersImpairmentDisordersDA receptor functionPoint of convergenceCrucial dimensionDimensional natureReceptor transmissionDopamine D2-like receptorsFeelingsSymptomatologyTreatment responseD2-like receptors