2016
Dopamine D3 Receptor Availability Is Associated with Inflexible Decision Making
Groman SM, Smith NJ, Petrullli JR, Massi B, Chen L, Ropchan J, Huang Y, Lee D, Morris ED, Taylor JR. Dopamine D3 Receptor Availability Is Associated with Inflexible Decision Making. Journal Of Neuroscience 2016, 36: 6732-6741. PMID: 27335404, PMCID: PMC4916249, DOI: 10.1523/jneurosci.3253-15.2016.Peer-Reviewed Original ResearchConceptsD3 receptor availabilityCorticostriatal brain regionsReversal-learning taskGoal-directed behaviorFlexible decision makingAbility of ratsReceptor availabilityFlexible adaptive behaviorDecision-making behaviorLearning rateIndividual differencesProbabilistic reinforcementReversal taskInitial learningProbabilistic discriminationReversal performanceDecision-making processCombined neuroimagingFlexible behaviorAdaptive behaviorComputational modelingReversal phaseSpatial acquisitionBrain regionsD3-preferring agonists
2012
Dysregulation of D2-Mediated Dopamine Transmission in Monkeys after Chronic Escalating Methamphetamine Exposure
Groman SM, Lee B, Seu E, James AS, Feiler K, Mandelkern MA, London ED, Jentsch JD. Dysregulation of D2-Mediated Dopamine Transmission in Monkeys after Chronic Escalating Methamphetamine Exposure. Journal Of Neuroscience 2012, 32: 5843-5852. PMID: 22539846, PMCID: PMC3353813, DOI: 10.1523/jneurosci.0029-12.2012.Peer-Reviewed Original ResearchMeSH Keywords3,4-Dihydroxyphenylacetic AcidAnalysis of VarianceAnimalsBehavior, AnimalBrainCentral Nervous System StimulantsChlorocebus aethiopsChoice BehaviorDiscrimination LearningDopamineDopamine Plasma Membrane Transport ProteinsDose-Response Relationship, DrugDrug Administration ScheduleFeedback, SensoryHomovanillic AcidMagnetic Resonance ImagingMaleMethamphetaminePositron-Emission TomographyReceptors, Dopamine D2Retention, PsychologyReversal LearningSynaptic TransmissionTime FactorsConceptsInhibitory control deficitsIndividual differencesInhibitory controlStimulus-outcome associationsLike receptor availabilityReversal-learning performancePositive feedback sensitivityStimulant-dependent individualsSubstance abuse behaviorsDopamine transmissionDrug-induced neuroadaptationsControl deficitsSelective impairmentDrugs of abuseDopaminergic neurochemistryEscalating-dose regimenLike receptorsMethamphetamine exposureSubstance dependenceDopamine systemBrain dopamine levelsDopamine transporter availabilityDopaminergic neurotransmissionReceptor availabilityDeficits
2010
Behavioral Characteristics and Neural Mechanisms Mediating Performance in a Rodent Version of the Balloon Analog Risk Task
Jentsch JD, Woods JA, Groman SM, Seu E. Behavioral Characteristics and Neural Mechanisms Mediating Performance in a Rodent Version of the Balloon Analog Risk Task. Neuropsychopharmacology 2010, 35: 1797-1806. PMID: 20375994, PMCID: PMC3055471, DOI: 10.1038/npp.2010.47.Peer-Reviewed Original ResearchConceptsBalloon Analogue Risk TaskRisk TaskPotential food rewardsMedial prefrontal cortexBiomarker of vulnerabilityRodent versionRisk-taking behaviorNeural basisIncentive motivationSuboptimal respondingFood rewardOrbitofrontal cortexPrefrontal cortexNeural circuitryHigh risk takingRewardGreater rewardsSubset of ratsLaboratory measuresFood pelletsHigh-risk behaviorsBehavioral characteristicsTaskCortexGreat public health concern
2007
Dimensions of Impulsivity Are Associated with Poor Spatial Working Memory Performance in Monkeys
James AS, Groman SM, Seu E, Jorgensen M, Fairbanks LA, Jentsch JD. Dimensions of Impulsivity Are Associated with Poor Spatial Working Memory Performance in Monkeys. Journal Of Neuroscience 2007, 27: 14358-14364. PMID: 18160643, PMCID: PMC6673444, DOI: 10.1523/jneurosci.4508-07.2007.Peer-Reviewed Original ResearchConceptsDimensions of impulsivityMemory performanceNonsocial stimuliResponse taskImpulsive behaviorDRD4 genotypeAttention-deficit/hyperactivity disorderDeficit/hyperactivity disorderSpatial Working Memory PerformanceHigh impulsive animalsWorking Memory PerformanceDelayed response taskDimensions of temperamentLow impulsive subjectsDRD4 allelesNeurocognitive endophenotypesDopamine D4 receptor geneHyperactivity disorderD4 receptor geneDimensional phenotypesCorrect responsesDelay versionImpulsivityCeiling levelImpulsive approach