2020
The Neurobiology of Impulsive Decision-Making and Reinforcement Learning in Nonhuman Animals
Groman SM. The Neurobiology of Impulsive Decision-Making and Reinforcement Learning in Nonhuman Animals. Current Topics In Behavioral Neurosciences 2020, 47: 23-52. PMID: 32157666, DOI: 10.1007/7854_2020_127.Peer-Reviewed Original ResearchConceptsImpulsive choiceNonhuman animalsReinforcement learning processSophisticated behavioralImpulsive decisionNeural mechanismsNeuroscience techniquesNeurobiological mechanismsNeuromodulatory systemsBehavioral heterogeneityApplication of reinforcementLearning processNeurochemical basisMental illnessIntegration of reinforcementImpulsivityPathological levels
2018
Neurochemical and Behavioral Dissections of Decision-Making in a Rodent Multistage Task
Groman SM, Massi B, Mathias SR, Curry DW, Lee D, Taylor JR. Neurochemical and Behavioral Dissections of Decision-Making in a Rodent Multistage Task. Journal Of Neuroscience 2018, 39: 295-306. PMID: 30413646, PMCID: PMC6325257, DOI: 10.1523/jneurosci.2219-18.2018.Peer-Reviewed Original ResearchConceptsMultistage taskBehavioral platformDopamine toneDecision Making TaskValue-based choiceDecision-making taskNovel behavioral paradigmModel-based learningConsequences of actionsReinforcement learning systemNeuroscience studiesBehavioral paradigmsBiobehavioral mechanismsVentral striatumNeurobehavioral levelBehavioral dissectionNovel analytic approachCortex correlatesRetrospective appraisalChoice behaviorTaskBehavioral mechanismsMental disordersModel-based systemLearning
2014
Primate Phencyclidine Model of Schizophrenia: Sex-Specific Effects on Cognition, Brain Derived Neurotrophic Factor, Spine Synapses, and Dopamine Turnover in Prefrontal Cortex
Elsworth JD, Groman SM, Jentsch JD, Leranth C, Redmond DE, Kim JD, Diano S, Roth RH. Primate Phencyclidine Model of Schizophrenia: Sex-Specific Effects on Cognition, Brain Derived Neurotrophic Factor, Spine Synapses, and Dopamine Turnover in Prefrontal Cortex. The International Journal Of Neuropsychopharmacology 2014, 18: pyu048. PMID: 25522392, PMCID: PMC4438537, DOI: 10.1093/ijnp/pyu048.Peer-Reviewed Original ResearchConceptsSpine synapse numberDorsolateral prefrontal cortexDopamine turnoverPhencyclidine treatmentSpine synapsesSynapse numberCognitive deficitsPrefrontal cortexPhencyclidine modelMale monkeysJuvenile monkeysSchizophrenia-related cognitive deficitsDendritic spine synapsesIncidence of schizophreniaAdult male monkeysSex-specific effectsMessenger RNABDNF expressionNeurotrophic factorNovel treatmentsCombined groupAdult nonhumanCore symptomsCortexNonhuman primates
2013
Identifying the molecular basis of inhibitory control deficits in addictions: neuroimaging in non-human primates
Groman SM, Jentsch JD. Identifying the molecular basis of inhibitory control deficits in addictions: neuroimaging in non-human primates. Current Opinion In Neurobiology 2013, 23: 625-631. PMID: 23528268, PMCID: PMC3731407, DOI: 10.1016/j.conb.2013.03.001.Peer-Reviewed Original ResearchConceptsNon-human primatesSerotonin systemStimulant-dependent individualsAddiction-related behaviorsInhibitory control deficitsTreatment of addictionDopamine systemNeural alterationsAddiction liabilityNovel targetStimulant useStimulant addictionFunctional phenotypeControl deficitsHuman primatesRecent dataInhibitory controlAddictionBi-directional relationshipBiological phenotypesPrimatesPhenotypeMonoamine Levels Within the Orbitofrontal Cortex and Putamen Interact to Predict Reversal Learning Performance
Groman SM, James AS, Seu E, Crawford MA, Harpster SN, Jentsch JD. Monoamine Levels Within the Orbitofrontal Cortex and Putamen Interact to Predict Reversal Learning Performance. Biological Psychiatry 2013, 73: 756-762. PMID: 23332512, PMCID: PMC3615106, DOI: 10.1016/j.biopsych.2012.12.002.Peer-Reviewed Original ResearchConceptsGoal-directed behaviorOrbitofrontal cortexReward-directed behaviorPsychiatric disordersObsessive-compulsive disorderIndividual differencesAssociative learningInflexible behaviorBehavioral flexibilityBehavioral addictionsCompulsive behaviorsImportant modulatory influenceDiscrimination problemNeuromodulatory systemsPutamen dopamineNeurochemical dysfunctionBehavioral impairmentsNeurochemical levelsNeurochemical systemsDorsal striatumModulatory influenceCurrent studyDopamine levelsCortexNeurochemical differences
2012
Dysregulation of D2-Mediated Dopamine Transmission in Monkeys after Chronic Escalating Methamphetamine Exposure
Groman SM, Lee B, Seu E, James AS, Feiler K, Mandelkern MA, London ED, Jentsch JD. Dysregulation of D2-Mediated Dopamine Transmission in Monkeys after Chronic Escalating Methamphetamine Exposure. Journal Of Neuroscience 2012, 32: 5843-5852. PMID: 22539846, PMCID: PMC3353813, DOI: 10.1523/jneurosci.0029-12.2012.Peer-Reviewed Original ResearchMeSH Keywords3,4-Dihydroxyphenylacetic AcidAnalysis of VarianceAnimalsBehavior, AnimalBrainCentral Nervous System StimulantsChlorocebus aethiopsChoice BehaviorDiscrimination LearningDopamineDopamine Plasma Membrane Transport ProteinsDose-Response Relationship, DrugDrug Administration ScheduleFeedback, SensoryHomovanillic AcidMagnetic Resonance ImagingMaleMethamphetaminePositron-Emission TomographyReceptors, Dopamine D2Retention, PsychologyReversal LearningSynaptic TransmissionTime FactorsConceptsInhibitory control deficitsIndividual differencesInhibitory controlStimulus-outcome associationsLike receptor availabilityReversal-learning performancePositive feedback sensitivityStimulant-dependent individualsSubstance abuse behaviorsDopamine transmissionDrug-induced neuroadaptationsControl deficitsSelective impairmentDrugs of abuseDopaminergic neurochemistryEscalating-dose regimenLike receptorsMethamphetamine exposureSubstance dependenceDopamine systemBrain dopamine levelsDopamine transporter availabilityDopaminergic neurotransmissionReceptor availabilityDeficits
2011
Cognitive control and the dopamine D2‐like receptor: a dimensional understanding of addiction
Groman SM, Jentsch JD. Cognitive control and the dopamine D2‐like receptor: a dimensional understanding of addiction. Depression And Anxiety 2011, 29: 295-306. PMID: 22147558, DOI: 10.1002/da.20897.Peer-Reviewed Original ResearchConceptsCognitive controlCognitive control abilitiesSubstantial psychosocial impairmentCognitive processesPsychosocial impairmentDimensional understandingCognitive dysfunctionControl abilityCategorical diagnosesPsychiatric conditionsParticular dimensionAddictionPsychiatric disordersImpairmentDisordersDA receptor functionPoint of convergenceCrucial dimensionDimensional natureReceptor transmissionDopamine D2-like receptorsFeelingsSymptomatologyTreatment responseD2-like receptors
2007
Dopamine D2/D3 Receptors Play a Specific Role in the Reversal of a Learned Visual Discrimination in Monkeys
Lee B, Groman S, London ED, Jentsch JD. Dopamine D2/D3 Receptors Play a Specific Role in the Reversal of a Learned Visual Discrimination in Monkeys. Neuropsychopharmacology 2007, 32: 2125-2134. PMID: 17299511, DOI: 10.1038/sj.npp.1301337.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AnimalBenzazepinesBrainChlorocebus aethiopsDiscrimination LearningDopamineDopamine AntagonistsDopamine D2 Receptor AntagonistsDose-Response Relationship, DrugMaleNeuropsychological TestsPattern Recognition, VisualPhotic StimulationRacloprideReceptors, Dopamine D1Receptors, Dopamine D2Receptors, Dopamine D3ConceptsD2/D3 receptorsReversal learningReversal sessionsVisual discriminationRetention sessionNovel discriminationD3 receptorsD1/D5 receptor antagonist SCH 23390Receptor antagonist SCH 23390Dopamine D2/D3 receptorsWisconsin General Test ApparatusD2/D3 receptor antagonist racloprideStimulus-reward contingenciesStimulus-reward associationsAntagonist SCH 23390Receptor antagonist racloprideVisual discrimination taskD2-like receptorsDopamine receptor antagonistUnique visual cuesMesocorticolimbic dopaminergic systemPhasic DA releaseNon-human primatesDopaminergic mechanismsAntagonist raclopride