2021
The effects of fatty acid amide hydrolase inhibition and monoacylglycerol lipase inhibition on habit formation in mice
Gianessi CA, Groman SM, Taylor JR. The effects of fatty acid amide hydrolase inhibition and monoacylglycerol lipase inhibition on habit formation in mice. European Journal Of Neuroscience 2021, 55: 922-938. PMID: 33506530, PMCID: PMC10370500, DOI: 10.1111/ejn.15129.Peer-Reviewed Original ResearchMeSH KeywordsAmidohydrolasesAnimalsEndocannabinoidsEnzyme InhibitorsHabitsMiceMonoacylglycerol LipasesReceptor, Cannabinoid, CB1ConceptsFatty acid amide hydrolase inhibitionResponse rateHydrolase inhibitionCannabinoid receptor type 1Aberrant habit formationInhibition of FAAHMonoacylglycerol lipase inhibitionInconsistent dose-response relationshipRole of CB1RSubstance use disordersEndocannabinoid ligand anandamideReceptor type 1Dose-response relationshipContingency degradation procedureEndocannabinoid signalingClinical utilityAM251Use disordersType 1Behavioral effectsPharmacological compoundsDose-response experimentsMiceLipase inhibitionAnandamide
2019
Endocannabinoid contributions to alcohol habits and motivation: Relevance to treatment
Gianessi CA, Groman SM, Thompson SL, Jiang M, van der Stelt M, Taylor JR. Endocannabinoid contributions to alcohol habits and motivation: Relevance to treatment. Addiction Biology 2019, 25: e12768. PMID: 31056846, PMCID: PMC7790504, DOI: 10.1111/adb.12768.Peer-Reviewed Original ResearchBi‐directional modulation of food habit expression by the endocannabinoid system
Gianessi CA, Groman SM, Taylor JR. Bi‐directional modulation of food habit expression by the endocannabinoid system. European Journal Of Neuroscience 2019, 49: 1610-1622. PMID: 30589475, PMCID: PMC7790508, DOI: 10.1111/ejn.14330.Peer-Reviewed Original ResearchConceptsCannabinoid receptor type 1Endocannabinoid systemTransient receptor potential cationHabitual respondingExpression of habitsMale C57BL/6 miceEndocannabinoid transport inhibitor AM404Potential pharmacological strategiesSubstance use disordersReceptor type 1Bi-directional modulationC57BL/6 micePharmacological strategiesCB1 receptorsPharmacological stimulationUse disordersEnzyme inhibitorsMental disordersType 1Neural circuitsNeuromodulatory systemsGoal-directed actionsSimilar reductionAM404Habit learning