2020
Midbrain D3 Receptor Availability Predicts Escalation in Cocaine Self-administration
Groman SM, Hillmer AT, Liu H, Fowles K, Holden D, Morris ED, Lee D, Taylor JR. Midbrain D3 Receptor Availability Predicts Escalation in Cocaine Self-administration. Biological Psychiatry 2020, 88: 767-776. PMID: 32312578, PMCID: PMC8954711, DOI: 10.1016/j.biopsych.2020.02.017.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCocaineCocaine-Related DisordersDopamine Uptake InhibitorsExtinction, PsychologicalMesencephalonRatsReceptors, Dopamine D3Self AdministrationConceptsProbabilistic reversalTests of extinctionSubstance-dependent individualsCue-induced reinstatementRelapse-like behaviorTest of motivationAddiction-like behaviorCocaine self-administration behaviorCocaine-taking behaviorReceptor availabilitySelf-administer cocaineIndividual differencesAddicted populationNeurobiological mechanismsSelf-administration behaviorGreater escalationGreater motivationPoor decisionsNeural adaptationD3 receptor availabilityCocaine Self-AdministrationBehavioral biomarkersDecision-making functionsChoice behaviorRate of escalation
2016
Dopamine D3 Receptor Availability Is Associated with Inflexible Decision Making
Groman SM, Smith NJ, Petrullli JR, Massi B, Chen L, Ropchan J, Huang Y, Lee D, Morris ED, Taylor JR. Dopamine D3 Receptor Availability Is Associated with Inflexible Decision Making. Journal Of Neuroscience 2016, 36: 6732-6741. PMID: 27335404, PMCID: PMC4916249, DOI: 10.1523/jneurosci.3253-15.2016.Peer-Reviewed Original ResearchConceptsD3 receptor availabilityCorticostriatal brain regionsReversal-learning taskGoal-directed behaviorFlexible decision makingAbility of ratsReceptor availabilityFlexible adaptive behaviorDecision-making behaviorLearning rateIndividual differencesProbabilistic reinforcementReversal taskInitial learningProbabilistic discriminationReversal performanceDecision-making processCombined neuroimagingFlexible behaviorAdaptive behaviorComputational modelingReversal phaseSpatial acquisitionBrain regionsD3-preferring agonists
2007
Dopamine D2/D3 Receptors Play a Specific Role in the Reversal of a Learned Visual Discrimination in Monkeys
Lee B, Groman S, London ED, Jentsch JD. Dopamine D2/D3 Receptors Play a Specific Role in the Reversal of a Learned Visual Discrimination in Monkeys. Neuropsychopharmacology 2007, 32: 2125-2134. PMID: 17299511, DOI: 10.1038/sj.npp.1301337.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AnimalBenzazepinesBrainChlorocebus aethiopsDiscrimination LearningDopamineDopamine AntagonistsDopamine D2 Receptor AntagonistsDose-Response Relationship, DrugMaleNeuropsychological TestsPattern Recognition, VisualPhotic StimulationRacloprideReceptors, Dopamine D1Receptors, Dopamine D2Receptors, Dopamine D3ConceptsD2/D3 receptorsReversal learningReversal sessionsVisual discriminationRetention sessionNovel discriminationD3 receptorsD1/D5 receptor antagonist SCH 23390Receptor antagonist SCH 23390Dopamine D2/D3 receptorsWisconsin General Test ApparatusD2/D3 receptor antagonist racloprideStimulus-reward contingenciesStimulus-reward associationsAntagonist SCH 23390Receptor antagonist racloprideVisual discrimination taskD2-like receptorsDopamine receptor antagonistUnique visual cuesMesocorticolimbic dopaminergic systemPhasic DA releaseNon-human primatesDopaminergic mechanismsAntagonist raclopride