Asenapine effects on cognitive and monoamine dysfunction elicited by subchronic phencyclidine administration
Elsworth JD, Groman SM, Jentsch JD, Valles R, Shahid M, Wong E, Marston H, Roth RH. Asenapine effects on cognitive and monoamine dysfunction elicited by subchronic phencyclidine administration. Neuropharmacology 2011, 62: 1442-1452. PMID: 21875607, PMCID: PMC3711239, DOI: 10.1016/j.neuropharm.2011.08.026.Peer-Reviewed Original ResearchConceptsBrain regionsExecutive functionCognitive dysfunctionPrefrontal cortexCognitive deficitsSubchronic phencyclidine administrationCognition-enhancing effectsDysregulation of neurotransmissionSame brain regionsReversal taskSpecific brain regionsPoor reversalAsenapine effectsOrbitofrontal cortexTrend levelSerotonin turnoverSerotonin utilizationControl monkeysFine motor functionPhencyclidine administrationMotor functionDeficitsDaily administrationNormal monkeysDiscrete brain regions