Targeted Interneuron Depletion in the Dorsal Striatum Produces Autism-like Behavioral Abnormalities in Male but Not Female Mice
Rapanelli M, Frick LR, Xu M, Groman SM, Jindachomthong K, Tamamaki N, Tanahira C, Taylor JR, Pittenger C. Targeted Interneuron Depletion in the Dorsal Striatum Produces Autism-like Behavioral Abnormalities in Male but Not Female Mice. Biological Psychiatry 2017, 82: 194-203. PMID: 28347488, PMCID: PMC5374721, DOI: 10.1016/j.biopsych.2017.01.020.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnxietyAutistic DisorderConditioning, OperantCorpus StriatumDisease Models, AnimalExploratory BehaviorFemaleImmunohistochemistryInterneuronsMaleMice, TransgenicMotor ActivityPrepulse InhibitionRibosomal Protein S6 Kinases, 90-kDaSex CharacteristicsSocial BehaviorStereotyped BehaviorSynaptic TransmissionConceptsCholinergic interneuronsTourette syndromeDorsal striatumFemale miceMale miceLarge cholinergic interneuronsAutism spectrum disorderToxin-mediated ablationAutism-like behavioral abnormalitiesAnxiety-like behaviorActivity-dependent signalingMale predominanceNeuronal abnormalitiesPotential relevancePreclinical modelsNormal miceInterneuron typesInterneuronal populationsBehavioral abnormalitiesBehavioral pathologyStriatumDimorphic mannerNeuropsychiatric disordersInterneuronsBehavioral effects