2014
In the Blink of an Eye: Relating Positive-Feedback Sensitivity to Striatal Dopamine D2-Like Receptors through Blink Rate
Groman SM, James AS, Seu E, Tran S, Clark TA, Harpster SN, Crawford M, Burtner JL, Feiler K, Roth RH, Elsworth JD, London ED, Jentsch JD. In the Blink of an Eye: Relating Positive-Feedback Sensitivity to Striatal Dopamine D2-Like Receptors through Blink Rate. Journal Of Neuroscience 2014, 34: 14443-14454. PMID: 25339755, PMCID: PMC4205561, DOI: 10.1523/jneurosci.3037-14.2014.Peer-Reviewed Original ResearchConceptsDopamine D2-like receptorsD2-like receptorsPositron emission tomographyStriatal dopamine D2-like receptorsPositive feedback sensitivityAdult male vervet monkeysDopamine D2 receptorsD2-like receptor availabilityDopaminergic transmissionPharmacological assessmentD2 receptorsMale vervet monkeysReceptor numberReceptor availabilityEmission tomographyBlink rateReceptorsSimple behavioral measurePET measurementsHuman brainReversal-learning performanceVervet monkeysBehavioral measuresHuman impulsivityBehavioral addictions
2011
Dorsal Striatal D2-Like Receptor Availability Covaries with Sensitivity to Positive Reinforcement during Discrimination Learning
Groman SM, Lee B, London ED, Mandelkern MA, James AS, Feiler K, Rivera R, Dahlbom M, Sossi V, Vandervoort E, Jentsch JD. Dorsal Striatal D2-Like Receptor Availability Covaries with Sensitivity to Positive Reinforcement during Discrimination Learning. Journal Of Neuroscience 2011, 31: 7291-7299. PMID: 21593313, PMCID: PMC3114883, DOI: 10.1523/jneurosci.0363-11.2011.Peer-Reviewed Original ResearchConceptsLike receptor availabilityIndividual differencesDiscrimination learningBehavioral flexibilitySpecific neurocognitive mechanismsVisual discrimination problemsBehavioral sensitivityReceptor availabilityNeurocognitive mechanismsReward sensitivityBehavioral performanceNeural mechanismsVisual discriminationNeuropsychiatric disordersPositive reinforcementReversal phaseEnvironmental contingenciesThree-choiceNumber of trialsPhenotypic dimensionsPsychiatric conditionsFeedback sensitivityLearningElectrophysiological findingsDisorders
2007
Dopamine D2/D3 Receptors Play a Specific Role in the Reversal of a Learned Visual Discrimination in Monkeys
Lee B, Groman S, London ED, Jentsch JD. Dopamine D2/D3 Receptors Play a Specific Role in the Reversal of a Learned Visual Discrimination in Monkeys. Neuropsychopharmacology 2007, 32: 2125-2134. PMID: 17299511, DOI: 10.1038/sj.npp.1301337.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AnimalBenzazepinesBrainChlorocebus aethiopsDiscrimination LearningDopamineDopamine AntagonistsDopamine D2 Receptor AntagonistsDose-Response Relationship, DrugMaleNeuropsychological TestsPattern Recognition, VisualPhotic StimulationRacloprideReceptors, Dopamine D1Receptors, Dopamine D2Receptors, Dopamine D3ConceptsD2/D3 receptorsReversal learningReversal sessionsVisual discriminationRetention sessionNovel discriminationD3 receptorsD1/D5 receptor antagonist SCH 23390Receptor antagonist SCH 23390Dopamine D2/D3 receptorsWisconsin General Test ApparatusD2/D3 receptor antagonist racloprideStimulus-reward contingenciesStimulus-reward associationsAntagonist SCH 23390Receptor antagonist racloprideVisual discrimination taskD2-like receptorsDopamine receptor antagonistUnique visual cuesMesocorticolimbic dopaminergic systemPhasic DA releaseNon-human primatesDopaminergic mechanismsAntagonist raclopride