2017
Targeted Interneuron Depletion in the Dorsal Striatum Produces Autism-like Behavioral Abnormalities in Male but Not Female Mice
Rapanelli M, Frick LR, Xu M, Groman SM, Jindachomthong K, Tamamaki N, Tanahira C, Taylor JR, Pittenger C. Targeted Interneuron Depletion in the Dorsal Striatum Produces Autism-like Behavioral Abnormalities in Male but Not Female Mice. Biological Psychiatry 2017, 82: 194-203. PMID: 28347488, PMCID: PMC5374721, DOI: 10.1016/j.biopsych.2017.01.020.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnxietyAutistic DisorderConditioning, OperantCorpus StriatumDisease Models, AnimalExploratory BehaviorFemaleImmunohistochemistryInterneuronsMaleMice, TransgenicMotor ActivityPrepulse InhibitionRibosomal Protein S6 Kinases, 90-kDaSex CharacteristicsSocial BehaviorStereotyped BehaviorSynaptic TransmissionConceptsCholinergic interneuronsTourette syndromeDorsal striatumFemale miceMale miceLarge cholinergic interneuronsAutism spectrum disorderToxin-mediated ablationAutism-like behavioral abnormalitiesAnxiety-like behaviorActivity-dependent signalingMale predominanceNeuronal abnormalitiesPotential relevancePreclinical modelsNormal miceInterneuron typesInterneuronal populationsBehavioral abnormalitiesBehavioral pathologyStriatumDimorphic mannerNeuropsychiatric disordersInterneuronsBehavioral effects
2011
Dorsal Striatal D2-Like Receptor Availability Covaries with Sensitivity to Positive Reinforcement during Discrimination Learning
Groman SM, Lee B, London ED, Mandelkern MA, James AS, Feiler K, Rivera R, Dahlbom M, Sossi V, Vandervoort E, Jentsch JD. Dorsal Striatal D2-Like Receptor Availability Covaries with Sensitivity to Positive Reinforcement during Discrimination Learning. Journal Of Neuroscience 2011, 31: 7291-7299. PMID: 21593313, PMCID: PMC3114883, DOI: 10.1523/jneurosci.0363-11.2011.Peer-Reviewed Original ResearchConceptsLike receptor availabilityIndividual differencesDiscrimination learningBehavioral flexibilitySpecific neurocognitive mechanismsVisual discrimination problemsBehavioral sensitivityReceptor availabilityNeurocognitive mechanismsReward sensitivityBehavioral performanceNeural mechanismsVisual discriminationNeuropsychiatric disordersPositive reinforcementReversal phaseEnvironmental contingenciesThree-choiceNumber of trialsPhenotypic dimensionsPsychiatric conditionsFeedback sensitivityLearningElectrophysiological findingsDisorders