2022
MicroPET evidence for a hypersensitive neuroinflammatory profile of gp120 mouse model of HIV
Young JW, Barback CV, Stolz LA, Groman SM, Vera DR, Hoh C, Kotta KK, Minassian A, Powell SB, Brody AL. MicroPET evidence for a hypersensitive neuroinflammatory profile of gp120 mouse model of HIV. Psychiatry Research Neuroimaging 2022, 321: 111445. PMID: 35101828, DOI: 10.1016/j.pscychresns.2022.111445.Peer-Reviewed Original ResearchConceptsGp120 transgenic miceWildtype miceTransgenic miceCognitive deficits persistElevated inflammatory profilesPositron emission tomography studyEmission tomography studiesElevated neuroinflammationNeuroinflammatory profileInflammatory profileInflammatory insultVentral striataHIV envelopeLipopolysaccharide treatmentHIV entryMouse modelHIVBehavioral abnormalitiesDeficits persistMiceTomography studyVivo evidenceEnvelope glycoproteinPLWHNeuroinflammation
2021
The effects of fatty acid amide hydrolase inhibition and monoacylglycerol lipase inhibition on habit formation in mice
Gianessi CA, Groman SM, Taylor JR. The effects of fatty acid amide hydrolase inhibition and monoacylglycerol lipase inhibition on habit formation in mice. European Journal Of Neuroscience 2021, 55: 922-938. PMID: 33506530, PMCID: PMC10370500, DOI: 10.1111/ejn.15129.Peer-Reviewed Original ResearchConceptsFatty acid amide hydrolase inhibitionResponse rateHydrolase inhibitionCannabinoid receptor type 1Aberrant habit formationInhibition of FAAHMonoacylglycerol lipase inhibitionInconsistent dose-response relationshipRole of CB1RSubstance use disordersEndocannabinoid ligand anandamideReceptor type 1Dose-response relationshipContingency degradation procedureEndocannabinoid signalingClinical utilityAM251Use disordersType 1Behavioral effectsPharmacological compoundsDose-response experimentsMiceLipase inhibitionAnandamide