2014
In the Blink of an Eye: Relating Positive-Feedback Sensitivity to Striatal Dopamine D2-Like Receptors through Blink Rate
Groman SM, James AS, Seu E, Tran S, Clark TA, Harpster SN, Crawford M, Burtner JL, Feiler K, Roth RH, Elsworth JD, London ED, Jentsch JD. In the Blink of an Eye: Relating Positive-Feedback Sensitivity to Striatal Dopamine D2-Like Receptors through Blink Rate. Journal Of Neuroscience 2014, 34: 14443-14454. PMID: 25339755, PMCID: PMC4205561, DOI: 10.1523/jneurosci.3037-14.2014.Peer-Reviewed Original ResearchConceptsDopamine D2-like receptorsD2-like receptorsPositron emission tomographyStriatal dopamine D2-like receptorsPositive feedback sensitivityAdult male vervet monkeysDopamine D2 receptorsD2-like receptor availabilityDopaminergic transmissionPharmacological assessmentD2 receptorsMale vervet monkeysReceptor numberReceptor availabilityEmission tomographyBlink rateReceptorsSimple behavioral measurePET measurementsHuman brainReversal-learning performanceVervet monkeysBehavioral measuresHuman impulsivityBehavioral addictions
2013
Methamphetamine-induced increases in putamen gray matter associate with inhibitory control
Groman SM, Morales AM, Lee B, London ED, Jentsch JD. Methamphetamine-induced increases in putamen gray matter associate with inhibitory control. Psychopharmacology 2013, 229: 527-538. PMID: 23748383, PMCID: PMC3770792, DOI: 10.1007/s00213-013-3159-9.Peer-Reviewed Original ResearchMeSH KeywordsAmphetamine-Related DisordersAnimalsChlorocebus aethiopsCognitionDiscrimination, PsychologicalDose-Response Relationship, DrugInhibition, PsychologicalMagnetic Resonance ImagingMaleMethamphetaminePositron-Emission TomographyPutamenReceptors, Dopamine D2Retention, PsychologyReversal LearningTime FactorsConceptsD2-like receptorsGray matterDrug usePositron emission tomography scanDopamine D2-like receptorsDrug-experienced individualsHuman methamphetamine usersRegimen of methamphetamineEmission tomography scanGray matter abnormalitiesMethamphetamine-induced increasesDrug-induced changesInhibitory controlNeurobiological risk factorsDopaminergic markersRisk factorsTomography scanDAT availabilityRight putamenTransporter availabilityPharmacological effectsStructural abnormalitiesRegimenMagnetic resonance imagesObjectivesThe purpose
2011
Cognitive control and the dopamine D2‐like receptor: a dimensional understanding of addiction
Groman SM, Jentsch JD. Cognitive control and the dopamine D2‐like receptor: a dimensional understanding of addiction. Depression And Anxiety 2011, 29: 295-306. PMID: 22147558, DOI: 10.1002/da.20897.Peer-Reviewed Original ResearchConceptsCognitive controlCognitive control abilitiesSubstantial psychosocial impairmentCognitive processesPsychosocial impairmentDimensional understandingCognitive dysfunctionControl abilityCategorical diagnosesPsychiatric conditionsParticular dimensionAddictionPsychiatric disordersImpairmentDisordersDA receptor functionPoint of convergenceCrucial dimensionDimensional natureReceptor transmissionDopamine D2-like receptorsFeelingsSymptomatologyTreatment responseD2-like receptors