2021
Reinforcement learning detuned in addiction: integrative and translational approaches
Groman SM, Thompson SL, Lee D, Taylor JR. Reinforcement learning detuned in addiction: integrative and translational approaches. Trends In Neurosciences 2021, 45: 96-105. PMID: 34920884, PMCID: PMC8770604, DOI: 10.1016/j.tins.2021.11.007.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDecision-making deficitsPathophysiology of addictionDecision-making strategiesBiobehavioral mechanismsAddictionReinforcement learningDecision-making processDrug useTranslational approachComputational componentsDeficitsLearningDifferent componentsBiological mechanismsOutcomesFindingsRecent studiesBehaviorStudy
2020
Paranoia as a deficit in non-social belief updating
Reed EJ, Uddenberg S, Suthaharan P, Mathys C, Taylor JR, Groman SM, Corlett PR. Paranoia as a deficit in non-social belief updating. ELife 2020, 9: e56345. PMID: 32452769, PMCID: PMC7326495, DOI: 10.7554/elife.56345.Peer-Reviewed Original ResearchConceptsParanoid individualsSocial threatLearning differencesTask environmentLearning behaviorOnline participantsMethamphetamine exposureParanoiaBeliefsVolatile environmentMental illnessComputational modelingIndividualsElevated sensitivityDeficitsAnticipationParticipantsParadigmThreatMethamphetamineDifferencesFurther assessmentBehaviorHarm
2012
An Evaluation of the Evidence that Methamphetamine Abuse Causes Cognitive Decline in Humans
Dean AC, Groman SM, Morales AM, London ED. An Evaluation of the Evidence that Methamphetamine Abuse Causes Cognitive Decline in Humans. Neuropsychopharmacology 2012, 38: 259-274. PMID: 22948978, PMCID: PMC3527116, DOI: 10.1038/npp.2012.179.Peer-Reviewed Original ResearchConceptsCognitive declineCognitive difficultiesMA abuseLine of researchCognitive functionCognitive deficitsModerator variablesMiddle adulthoodCross-sectional human studiesBrain structuresTwin studiesAbuseIllicit substancesMethamphetamine abuseAbstinenceCognitionMethamphetamineIndividualsCausal relationshipDifficultiesRelationshipHuman studiesDeficitsFindingsAdulthoodDysregulation of D2-Mediated Dopamine Transmission in Monkeys after Chronic Escalating Methamphetamine Exposure
Groman SM, Lee B, Seu E, James AS, Feiler K, Mandelkern MA, London ED, Jentsch JD. Dysregulation of D2-Mediated Dopamine Transmission in Monkeys after Chronic Escalating Methamphetamine Exposure. Journal Of Neuroscience 2012, 32: 5843-5852. PMID: 22539846, PMCID: PMC3353813, DOI: 10.1523/jneurosci.0029-12.2012.Peer-Reviewed Original ResearchMeSH Keywords3,4-Dihydroxyphenylacetic AcidAnalysis of VarianceAnimalsBehavior, AnimalBrainCentral Nervous System StimulantsChlorocebus aethiopsChoice BehaviorDiscrimination LearningDopamineDopamine Plasma Membrane Transport ProteinsDose-Response Relationship, DrugDrug Administration ScheduleFeedback, SensoryHomovanillic AcidMagnetic Resonance ImagingMaleMethamphetaminePositron-Emission TomographyReceptors, Dopamine D2Retention, PsychologyReversal LearningSynaptic TransmissionTime FactorsConceptsInhibitory control deficitsIndividual differencesInhibitory controlStimulus-outcome associationsLike receptor availabilityReversal-learning performancePositive feedback sensitivityStimulant-dependent individualsSubstance abuse behaviorsDopamine transmissionDrug-induced neuroadaptationsControl deficitsSelective impairmentDrugs of abuseDopaminergic neurochemistryEscalating-dose regimenLike receptorsMethamphetamine exposureSubstance dependenceDopamine systemBrain dopamine levelsDopamine transporter availabilityDopaminergic neurotransmissionReceptor availabilityDeficits
2011
Asenapine effects on cognitive and monoamine dysfunction elicited by subchronic phencyclidine administration
Elsworth JD, Groman SM, Jentsch JD, Valles R, Shahid M, Wong E, Marston H, Roth RH. Asenapine effects on cognitive and monoamine dysfunction elicited by subchronic phencyclidine administration. Neuropharmacology 2011, 62: 1442-1452. PMID: 21875607, PMCID: PMC3711239, DOI: 10.1016/j.neuropharm.2011.08.026.Peer-Reviewed Original ResearchConceptsBrain regionsExecutive functionCognitive dysfunctionPrefrontal cortexCognitive deficitsSubchronic phencyclidine administrationCognition-enhancing effectsDysregulation of neurotransmissionSame brain regionsReversal taskSpecific brain regionsPoor reversalAsenapine effectsOrbitofrontal cortexTrend levelSerotonin turnoverSerotonin utilizationControl monkeysFine motor functionPhencyclidine administrationMotor functionDeficitsDaily administrationNormal monkeysDiscrete brain regions