2021
Reinforcement learning detuned in addiction: integrative and translational approaches
Groman SM, Thompson SL, Lee D, Taylor JR. Reinforcement learning detuned in addiction: integrative and translational approaches. Trends In Neurosciences 2021, 45: 96-105. PMID: 34920884, PMCID: PMC8770604, DOI: 10.1016/j.tins.2021.11.007.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDecision-making deficitsPathophysiology of addictionDecision-making strategiesBiobehavioral mechanismsAddictionReinforcement learningDecision-making processDrug useTranslational approachComputational componentsDeficitsLearningDifferent componentsBiological mechanismsOutcomesFindingsRecent studiesBehaviorStudy
2017
Chronic Exposure to Methamphetamine Disrupts Reinforcement-Based Decision Making in Rats
Groman SM, Rich KM, Smith NJ, Lee D, Taylor JR. Chronic Exposure to Methamphetamine Disrupts Reinforcement-Based Decision Making in Rats. Neuropsychopharmacology 2017, 43: 770-780. PMID: 28741627, PMCID: PMC5809784, DOI: 10.1038/npp.2017.159.Peer-Reviewed Original ResearchConceptsReinforcement learning processAbility of ratsNegative outcomesAdaptive decision-making strategiesProbabilistic reversal learningStimulus-reward contingenciesDopamine D2/3 receptor antagonistDynamic decision makingMaladaptive decisionReversal learningDecision-making strategiesD2/3 receptor antagonistOutcome behaviorsPsychostimulant methamphetamineChronic exposurePsychostimulant addictionChoice behaviorBehavioral mechanismsComputational modelDetrimental outcomesPsychostimulant drugsCurrent studyDecision makingDecision-making processDrug use