Chronic Exposure to Methamphetamine Disrupts Reinforcement-Based Decision Making in Rats
Groman SM, Rich KM, Smith NJ, Lee D, Taylor JR. Chronic Exposure to Methamphetamine Disrupts Reinforcement-Based Decision Making in Rats. Neuropsychopharmacology 2017, 43: 770-780. PMID: 28741627, PMCID: PMC5809784, DOI: 10.1038/npp.2017.159.Peer-Reviewed Original ResearchConceptsReinforcement learning processAbility of ratsNegative outcomesAdaptive decision-making strategiesProbabilistic reversal learningStimulus-reward contingenciesDopamine D2/3 receptor antagonistDynamic decision makingMaladaptive decisionReversal learningDecision-making strategiesD2/3 receptor antagonistOutcome behaviorsPsychostimulant methamphetamineChronic exposurePsychostimulant addictionChoice behaviorBehavioral mechanismsComputational modelDetrimental outcomesPsychostimulant drugsCurrent studyDecision makingDecision-making processDrug useExplaining Delusions: Reducing Uncertainty Through Basic and Computational Neuroscience
Feeney EJ, Groman SM, Taylor JR, Corlett PR. Explaining Delusions: Reducing Uncertainty Through Basic and Computational Neuroscience. Schizophrenia Bulletin 2017, 43: 263-272. PMID: 28177090, PMCID: PMC5605246, DOI: 10.1093/schbul/sbw194.Peer-Reviewed Original ResearchConceptsAssociative learning theoryPersistence of delusionsAttentional allocationCognitive psychologySet of beliefsAnimal beliefsNew learningComputational neuroscienceLearning theoryHuman beliefsErroneous beliefsBelief characteristicsBrain functionConsensual realityClinical phenomenologyAnimal researchBeliefsDelusionsComputational modelPsychotic illnessPsychologyPharmacological treatmentNeuroscienceTeleological approachFuture state