Opposite Modulation of Opiate Withdrawal Behaviors on Microinfusion of a Protein Kinase A Inhibitor Versus Activator into the Locus Coeruleus or Periaqueductal Gray
Punch L, Self D, Nestler E, Taylor J. Opposite Modulation of Opiate Withdrawal Behaviors on Microinfusion of a Protein Kinase A Inhibitor Versus Activator into the Locus Coeruleus or Periaqueductal Gray. Journal Of Neuroscience 1997, 17: 8520-8527. PMID: 9334424, PMCID: PMC6573752, DOI: 10.1523/jneurosci.17-21-08520.1997.Peer-Reviewed Original ResearchAmygdalaAnimalsBehavior, AnimalCyclic AMPCyclic AMP-Dependent Protein KinasesEnzyme InhibitorsInfusions, ParenteralLocus CoeruleusMaleMorphine DependenceMotor ActivityNaloxoneNarcotic AntagonistsNerve Tissue ProteinsPeriaqueductal GrayPhosphorylationProtein Processing, Post-TranslationalRatsRats, Sprague-DawleySecond Messenger SystemsStereotyped BehaviorSubstance Withdrawal SyndromeThionucleotidesTyrosine 3-MonooxygenaseSupranormal Stimulation of D1 Dopamine Receptors in the Rodent Prefrontal Cortex Impairs Spatial Working Memory Performance
Zahrt J, Taylor J, Mathew R, Arnsten A. Supranormal Stimulation of D1 Dopamine Receptors in the Rodent Prefrontal Cortex Impairs Spatial Working Memory Performance. Journal Of Neuroscience 1997, 17: 8528-8535. PMID: 9334425, PMCID: PMC6573725, DOI: 10.1523/jneurosci.17-21-08528.1997.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBenzazepinesDopamineDopamine AgonistsDopamine AntagonistsInfusions, ParenteralMaleMaze LearningMemoryModels, NeurologicalModels, PsychologicalPrefrontal CortexPsychomotor PerformanceRatsRats, Sprague-DawleyReceptors, Dopamine D1Receptors, N-Methyl-D-AspartateSpatial BehaviorStress, PsychologicalConceptsD1 receptor stimulationPrefrontal cortexReceptor stimulationSKF 81297SCH 23390D1 receptorsSupranormal stimulationPFC of ratsD1 receptor mechanismsDA receptor stimulationDose-related impairmentD1 receptor antagonistD1 receptor agonistD1 dopamine receptorsDelayed-alternation performanceMemory functionRecent electrophysiological studiesSpatial Working Memory PerformanceReceptor antagonistReceptor agonistDopamine receptorsReceptor mechanismsElectrophysiological studiesHigh dosesDrug efficacy