2001
Embryonic ventral mesencephalic grafts to the substantia nigra of MPTP‐treated monkeys: Feasibility relevant to multiple‐target grafting as a therapy for Parkinson's disease
Collier TJ, Sortwell CE, Elsworth JD, Taylor JR, Roth RH, Sladek JR, Redmond DE. Embryonic ventral mesencephalic grafts to the substantia nigra of MPTP‐treated monkeys: Feasibility relevant to multiple‐target grafting as a therapy for Parkinson's disease. The Journal Of Comparative Neurology 2001, 442: 320-330. PMID: 11793337, DOI: 10.1002/cne.10108.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsBrain Tissue TransplantationCell DifferentiationChlorocebus aethiopsDopamineGraft SurvivalHomovanillic AcidImmunohistochemistryMaleNeostriatumNerve RegenerationNeuritesNeuronsParkinsonian DisordersRecovery of FunctionStem Cell TransplantationStem CellsSubstantia NigraTreatment OutcomeTyrosine 3-MonooxygenaseConceptsSubstantia nigraParkinson's diseaseDA neuronsVentral mesencephalonTyrosine hydroxylaseTH-positive fiber densityEmbryonic DA neuronsEmbryonic dopamine neuronsRostral substantia nigraStriatal DA depletionVentral mesencephalic graftsBasal ganglia circuitryBasal ganglia structuresSuboptimal therapeutic outcomesAfrican green monkeysDA modulationGrafted neuronsVM graftsMesencephalic graftsParkinsonian monkeysSN neuronsDA depletionReplacement therapyDA replacementDA levels
1998
In vivo expression of therapeutic human genes for dopamine production in the caudates of MPTP-treated monkeys using an AAV vector
During M, Samulski R, Elsworth J, Kaplitt M, Leone P, Xiao X, Li J, Freese A, Taylor J, Roth R, Sladek J, O’Malley K, Redmond D. In vivo expression of therapeutic human genes for dopamine production in the caudates of MPTP-treated monkeys using an AAV vector. Gene Therapy 1998, 5: 820-827. PMID: 9747462, DOI: 10.1038/sj.gt.3300650.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsAromatic-L-Amino-Acid DecarboxylasesChlorocebus aethiopsDependovirusDopamineDopamine AgentsGene ExpressionGene Transfer TechniquesGenetic VectorsHumansImmunohistochemistryMaleParkinson DiseaseTrigeminal Caudal NucleusTyrosine 3-MonooxygenaseConceptsTyrosine hydroxylaseStriatal cellsDopamine-depleted monkeysAdeno-associated virus vectorProduction of dopamineParkinsonian monkeysTransient feverSevere hyperactivityStriatal dopaminePrimate neuronsStereotactic injectionHistological evidencePrimate modelInjection tractNeurotoxin MPTPDopamine productionParkinson's diseaseTreatment groupsSignificant toxicityBehavioral effectsVivo gene therapyElevated levelsBiochemical effectsFirst dayMonkeysPattern of synaptophysin immunoreactivity within mesencephalic grafts following transplantation in a parkinsonian primate model
Sortwell C, Blanchard B, Collier T, Elsworth J, Taylor J, Roth R, Redmond D, Sladek J. Pattern of synaptophysin immunoreactivity within mesencephalic grafts following transplantation in a parkinsonian primate model. Brain Research 1998, 791: 117-124. PMID: 9593853, DOI: 10.1016/s0006-8993(98)00086-9.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCercopithecusDisease Models, AnimalFetal Tissue TransplantationImmunohistochemistryMaleMesencephalonParkinson Disease, SecondarySynaptophysinConceptsGraft-host interactionsMesencephalic graftsFunctional synapsesTyrosine hydroxylaseCerebellar tissuePericellular arraysEmbryonic cerebellar tissueEmbryonic ventral mesencephalonGrafted dopamine neuronsNerve terminal differentiationTH-positive neuronsStriatum of MPTPEnzyme tyrosine hydroxylaseSynthetic enzyme tyrosine hydroxylaseAfrican green monkeysNeurochemical subtypesStriatal portionDA neuronsSynaptophysin immunoreactivityVentral mesencephalonGraft typeDopamine neuronsPrimate modelStriatal targetsSynaptic remodeling
1997
Metabolic energy capacity of dopaminergic grafts and the implanted striatum in parkinsonian nonhuman primates as visualized with cytochrome oxidase histochemistry
Collier T, Redmond D, Roth R, Elsworth J, Taylor J, Sladek J. Metabolic energy capacity of dopaminergic grafts and the implanted striatum in parkinsonian nonhuman primates as visualized with cytochrome oxidase histochemistry. Cell Transplantation 1997, 6: 135-140. DOI: 10.1016/s0963-6897(97)00003-1.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsBrain Tissue TransplantationChlorocebus aethiopsCorpus StriatumDopamineElectron Transport Complex IVEnergy MetabolismFetal Tissue TransplantationGestational AgeImmunohistochemistryMesencephalonNeuronsParkinson Disease, SecondaryTyrosine 3-MonooxygenaseConceptsDA neuronsEmbryonic ventral mesencephalic tissueParkinsonian nonhuman primatesStriatum of DATyrosine hydroxylase immunocytochemistryVentral mesencephalic tissueVentral mesencephalic graftsCytochrome oxidase histochemistryCytochrome oxidase stainingMitochondrial enzyme cytochrome oxidaseLocal energy metabolismActive innervationBilateral graftsNeuron contentDopaminergic graftsMesencephalic graftsMesencephalic tissueHost brainBrain metabolismEnzyme cytochrome oxidaseCO stainingTissue transplantsGraftMetabolic activityNonhuman primatesMetabolic Energy Capacity of Dopaminergic Grafts and the Implanted Striatum in Parkinsonian Nonhuman Primates as Visualized with Cytochrome Oxidase Histochemistry
Collier T, Redmond D, Roth R, Elsworth J, Taylor J, Sladek J. Metabolic Energy Capacity of Dopaminergic Grafts and the Implanted Striatum in Parkinsonian Nonhuman Primates as Visualized with Cytochrome Oxidase Histochemistry. Cell Transplantation 1997, 6: 135-140. PMID: 9142445, DOI: 10.1177/096368979700600207.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsBrain Tissue TransplantationChlorocebus aethiopsCorpus StriatumDopamineElectron Transport Complex IVEnergy MetabolismFetal Tissue TransplantationGestational AgeImmunohistochemistryMesencephalonNeuronsParkinson Disease, SecondaryTyrosine 3-MonooxygenaseConceptsDA neuronsEmbryonic ventral mesencephalic tissueParkinsonian nonhuman primatesStriatum of DATyrosine hydroxylase immunocytochemistryVentral mesencephalic tissueVentral mesencephalic graftsBrain energy metabolismCytochrome oxidase histochemistryCytochrome oxidase stainingMitochondrial enzyme cytochrome oxidaseLocal energy metabolismEnergy metabolismActive innervationBilateral graftsNeuron contentDopaminergic graftsMesencephalic graftsMesencephalic tissueHost brainEnzyme cytochrome oxidaseCO stainingTissue transplantsGraftMetabolic activity
1994
Peripheral nerve-dopamine neuron co-grafts in mptp-treated monkeys: Augmentation of tyrosine hydroxylase-positive fiber staining and dopamine content in host systems
Collier T, Elsworth J, Taylor J, Sladek J, Roth R, Redmond D. Peripheral nerve-dopamine neuron co-grafts in mptp-treated monkeys: Augmentation of tyrosine hydroxylase-positive fiber staining and dopamine content in host systems. Neuroscience 1994, 61: 875-889. PMID: 7838385, DOI: 10.1016/0306-4522(94)90410-3.Peer-Reviewed Original ResearchConceptsDopamine neuronsCaudate nucleusNon-human primatesLateral ventricleSeptal areaDopamine systemEmbryonic ventral mesencephalic tissueTyrosine hydroxylase-positive fibersHomovanillic acid/dopamine ratioDopamine neuron graftsDopamine-depleted monkeysEmbryonic ventral mesencephalonGrafted dopamine neuronsVentral mesencephalic tissueLateral septal areaLevels of dopamineMesencephalic dopamine neuronsMetabolite homovanillic acidBrain dopamine systemsMPTP-treated monkeysDirection of normalizationAfrican green monkeysInjury-induced regenerationMesencephalic tissueSaphenous nerve
1993
Fetal Dopamine Cell Survival after Transplantation Is Dramatically Improved at a Critical Donor Gestational Age in Nonhuman Primates
Sladek J, Elsworth J, Roth R, Evans L, Collier T, Cooper S, Taylor J, Redmond D. Fetal Dopamine Cell Survival after Transplantation Is Dramatically Improved at a Critical Donor Gestational Age in Nonhuman Primates. Experimental Neurology 1993, 122: 16-27. PMID: 8101820, DOI: 10.1006/exnr.1993.1103.Peer-Reviewed Original ResearchConceptsDopamine neuronsCaudate nucleusMesencephalic dopamine cell groupsTyrosine hydroxylase-positive neuronsTissue dopamine levelsUnfixed brain slicesDopamine cell groupsCell survivalDopamine cell survivalDopamine cell numberDays of gestationEarly gestation tissuesTime of implantationAfrican green monkeysVideo-based imagingGraft survivalMesencephalic tissueDonor graftsGestational ageNeural graftsNeurological disabilityDopaminergic neuronsGraft sizeDopamine contentSingle graft