Featured Publications
Dysregulation of Decision Making Related to Metabotropic Glutamate 5, but Not Midbrain D3, Receptor Availability Following Cocaine Self-administration in Rats
Groman SM, Hillmer AT, Liu H, Fowles K, Holden D, Morris ED, Lee D, Taylor JR. Dysregulation of Decision Making Related to Metabotropic Glutamate 5, but Not Midbrain D3, Receptor Availability Following Cocaine Self-administration in Rats. Biological Psychiatry 2020, 88: 777-787. PMID: 32826065, PMCID: PMC8935943, DOI: 10.1016/j.biopsych.2020.06.020.Peer-Reviewed Original ResearchConceptsCocaine-dependent individualsProbabilistic reversalRelapse-like behaviorTest of motivationReceptor availabilityPersistent drug useMetabotropic glutamate 5Neural mechanismsCompulsive patternsDecision-making processDrug-induced adaptationsSelective impairmentDrug useWeeks of abstinenceCocaine takingCocaine Self-AdministrationBrain regionsDegree of disruptionDays of cocaineAdult male ratsCocaine-induced increasesCocaine-induced changesDrug-induced alterationsRobust alterationsPositron emission tomography
2009
Prior chronic cocaine exposure in mice induces persistent alterations in cognitive function
Krueger DD, Howell JL, Oo H, Olausson P, Taylor JR, Nairn AC. Prior chronic cocaine exposure in mice induces persistent alterations in cognitive function. Behavioural Pharmacology 2009, 20: 695-704. PMID: 19901826, PMCID: PMC3380449, DOI: 10.1097/fbp.0b013e328333a2bb.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAttentionCocaineCocaine-Related DisordersCognitionConditioning, ClassicalConditioning, OperantDisease Models, AnimalImpulsive BehaviorInhibition, PsychologicalInjections, IntraperitonealMaleMemory DisordersMemory, Short-TermMiceMice, Inbred C57BLMotor ActivityReinforcement ScheduleReinforcement, PsychologyReversal LearningTime FactorsConceptsCognitive functionAttentional functionsResponse inhibitionPrefrontal cortexThree-choice serial reaction time taskSerial reaction time taskReaction time taskPattern of errorsCocaine exposureDevelopment of addictionPrior chronic exposureCognitive flexibilityInstrumental reversalTime taskPosition taskChronic cocaine exposureChronic cocaine useCognitive dysfunctionTaskMemoryCocaine useDrug-free periodSuitable animal modelMultiple aspectsCortexLoss of dendrite stabilization by the Abl-related gene (Arg) kinase regulates behavioral flexibility and sensitivity to cocaine
Gourley SL, Koleske AJ, Taylor JR. Loss of dendrite stabilization by the Abl-related gene (Arg) kinase regulates behavioral flexibility and sensitivity to cocaine. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 16859-16864. PMID: 19805386, PMCID: PMC2742404, DOI: 10.1073/pnas.0902286106.Peer-Reviewed Original ResearchConceptsDopamine D2 receptor levelsLocomotor depressant actionsD2 receptor levelsWild-type micePsychomotor stimulant actionDendritic simplificationAntagonist haloperidolStimulant actionCocaine exposureCortical axonsDendritic arborsReceptor levelsCocaine administrationSynaptic pruningDendrite stabilizationNeuropsychiatric disordersArg inhibitionMiceNormal sensitivityDendritic refinementCytoskeletal stabilizationCocaineAdolescenceReversal taskRhoA GTPase
2005
Persistent changes in motivation to self‐administer cocaine following modulation of cyclic AMP‐dependent protein kinase A (PKA) activity in the nucleus accumbens
Lynch W, Taylor J. Persistent changes in motivation to self‐administer cocaine following modulation of cyclic AMP‐dependent protein kinase A (PKA) activity in the nucleus accumbens. European Journal Of Neuroscience 2005, 22: 1214-1220. PMID: 16176364, DOI: 10.1111/j.1460-9568.2005.04305.x.Peer-Reviewed Original Research
2001
Repeated intermittent administration of psychomotor stimulant drugs alters the acquisition of Pavlovian approach behavior in rats: differential effects of cocaine, d-amphetamine and 3,4-methylenedioxymethamphetamine (“ecstasy”)
Taylor J, Jentsch J. Repeated intermittent administration of psychomotor stimulant drugs alters the acquisition of Pavlovian approach behavior in rats: differential effects of cocaine, d-amphetamine and 3,4-methylenedioxymethamphetamine (“ecstasy”). Biological Psychiatry 2001, 50: 137-143. PMID: 11526995, DOI: 10.1016/s0006-3223(01)01106-4.Peer-Reviewed Original ResearchEffects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5
Bibb J, Chen J, Taylor J, Svenningsson P, Nishi A, Snyder G, Yan Z, Sagawa Z, Ouimet C, Nairn A, Nestler E, Greengard P. Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5. Nature 2001, 410: 376-380. PMID: 11268215, DOI: 10.1038/35066591.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCocaineCocaine-Related DisordersCorpus StriatumCyclin-Dependent Kinase 5Cyclin-Dependent KinasesDopamineDopamine and cAMP-Regulated Phosphoprotein 32Enzyme InhibitorsGene Expression Regulation, EnzymologicKinetinMaleMiceMice, TransgenicNerve Tissue ProteinsNeuronsOligonucleotide Array Sequence AnalysisPhosphoproteinsPhosphorylationProto-Oncogene Proteins c-fosPsychomotor PerformancePurinesRatsRats, Sprague-DawleyReceptors, Dopamine D1RoscovitineSignal TransductionConceptsTranscription factorsSuch transcription factorsDownstream target genesCyclin-dependent kinase 5DNA array analysisTarget genesGene expressionCocaine administrationKinase 5Inducible transgenic miceChronic exposureCdk5 inhibitorMessenger RNACocaine addictionArray analysisDopamine-mediated neurotransmissionDopamine-containing nerve terminalsMedium spiny neuronsD1 dopamine receptorsChronic cocaine administrationOverexpression of ΔFosBProteinTransgenic miceAdaptive changesSpiny neurons
1999
Enhancement of Locomotor Activity and Conditioned Reward to Cocaine by Brain-Derived Neurotrophic Factor
Horger B, Iyasere C, Berhow M, Messer C, Nestler E, Taylor J. Enhancement of Locomotor Activity and Conditioned Reward to Cocaine by Brain-Derived Neurotrophic Factor. Journal Of Neuroscience 1999, 19: 4110-4122. PMID: 10234039, PMCID: PMC6782687, DOI: 10.1523/jneurosci.19-10-04110.1999.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorDevelopment of sensitizationLocomotor sensitizationBDNF infusionNeurotrophic factorNucleus accumbensStimulant effectsInitial stimulant effectMesolimbic DA systemCocaine-induced locomotionVentral tegmental areaMesolimbic dopamine systemWild-type littermatesPsychomotor stimulant effectsBDNF administrationDopaminergic neuronsTegmental areaCocaine injectionCocaine dosesControl animalsDopamine systemLocomotor activityDrug rewardCR leverDA systemEnhanced responding for conditioned reward produced by intra-accumbens amphetamine is potentiated after cocaine sensitization
Taylor J, Horger B. Enhanced responding for conditioned reward produced by intra-accumbens amphetamine is potentiated after cocaine sensitization. Psychopharmacology 1999, 142: 31-40. PMID: 10102780, DOI: 10.1007/s002130050859.Peer-Reviewed Original ResearchConceptsIntra-accumbens amphetamineIntra-NAc amphetamineCocaine sensitizationLocomotor sensitizationNucleus accumbensCR leverLong-term neuronal adaptationsSaline-treated groupMesolimbic dopamine systemStimulant drug useSaline infusionSaline injectionDopamine systemPsychomotor stimulantsDrug useNeuronal adaptationConditioned rewardStimulant drugsAmphetaminePrior exposureSensitizationTest daySeparate groupsNCR leverPredictive associations
1997
(S)-(-)-HA-966, a gamma-hydroxybutyrate-like agent, prevents enhanced mesocorticolimbic dopamine metabolism and behavioral correlates of restraint stress, conditioned fear and cocaine sensitization.
Morrow B, Lee E, Taylor J, Elsworth J, Nye H, Roth R. (S)-(-)-HA-966, a gamma-hydroxybutyrate-like agent, prevents enhanced mesocorticolimbic dopamine metabolism and behavioral correlates of restraint stress, conditioned fear and cocaine sensitization. Journal Of Pharmacology And Experimental Therapeutics 1997, 283: 712-21. PMID: 9353390.Peer-Reviewed Original ResearchConceptsHA-966Dopamine metabolismMedial prefrontal cortexCocaine sensitizationNucleus accumbensHigh doseAcute cocaine-induced locomotionPrefrontal cortexGABAB receptor bindingCocaine-induced locomotionGamma-aminobutyric acidStress-induced increaseFear-inducing behaviorDopamine utilizationGABAB receptorsRestraint stressControl ratsLocomotor sensitizationDopaminergic neurotransmissionShell subdivisionBaclofen bindingCortical membranesPositive enantiomerWeight gainReceptor binding
1996
Sensitization to the locomotor activating effects of cocaine following cocaethylene-preexposure
Horger B, Taylor J, Elsworth J, Jatlow P, Roth R. Sensitization to the locomotor activating effects of cocaine following cocaethylene-preexposure. Brain Research 1996, 733: 133-137. PMID: 8891259, DOI: 10.1016/0006-8993(96)00783-4.Peer-Reviewed Original ResearchAlcohol plus cocaine: the whole is more than the sum of its parts.
Jatlow P, McCance E, Bradberry C, Elsworth J, Taylor J, Roth R. Alcohol plus cocaine: the whole is more than the sum of its parts. Therapeutic Drug Monitoring 1996, 18: 460-4. PMID: 8857569, DOI: 10.1097/00007691-199608000-00026.Peer-Reviewed Original ResearchRestoration of dopamine transporter density in the striatum of fetal ventral mesencephalon-grafted, but not sham-grafted, MPTP-treated parkinsonian monkeys
Elsworth J, Brittan M, Taylor J, Sladek J, Al-Tikriti M, Zea-Ponce Y, Innis R, Redmond D, Roth R. Restoration of dopamine transporter density in the striatum of fetal ventral mesencephalon-grafted, but not sham-grafted, MPTP-treated parkinsonian monkeys. Cell Transplantation 1996, 5: 315-325. DOI: 10.1016/0963-6897(95)02034-9.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsAutoradiographyBrain Tissue TransplantationCarrier ProteinsChlorocebus aethiopsCocaineDopamineDopamine Plasma Membrane Transport ProteinsFetal Tissue TransplantationHomovanillic AcidIodine RadioisotopesMaleMembrane GlycoproteinsMembrane Transport ProteinsMesencephalonNeostriatumNerve Tissue ProteinsParkinson Disease, SecondaryProtein BindingPutamenConceptsFetal dopamine neuronsDopamine transporter densityDopamine neuronsParkinsonian monkeysBehavioral recoveryTransporter densityCaudate nucleusNeural graftingDopamine systemImplantation procedureDopamine concentrationsFull behavioral recoveryPutamen of MPTPStriatal dopamine deficiencyStriatal dopamine concentrationsDopamine-depleted striatumStriatum of MPTPDopamine depletionVentral mesencephalonDopamine deficiencyMotor abnormalitiesDopaminergic innervationUseful treatmentStriatal nucleiAdult striatumRestoration of Dopamine Transporter Density in the Striatum of Fetal Ventral Mesencephalon-Grafted, but not Sham-Grafted, Mptp-Treated Parkinsonian Monkeys
Elsworth J, Brittan M, Taylor J, Sladek J, Al-Tikriti M, Zea-Ponce Y, Innis R, Redmond D, Roth R. Restoration of Dopamine Transporter Density in the Striatum of Fetal Ventral Mesencephalon-Grafted, but not Sham-Grafted, Mptp-Treated Parkinsonian Monkeys. Cell Transplantation 1996, 5: 315-325. PMID: 8689042, DOI: 10.1177/096368979600500220.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsAutoradiographyBrain Tissue TransplantationCarrier ProteinsChlorocebus aethiopsCocaineDopamineDopamine Plasma Membrane Transport ProteinsFetal Tissue TransplantationHomovanillic AcidIodine RadioisotopesMaleMembrane GlycoproteinsMembrane Transport ProteinsMesencephalonNeostriatumNerve Tissue ProteinsParkinson Disease, SecondaryProtein BindingPutamenConceptsFetal dopamine neuronsDopamine transporter densityDopamine neuronsParkinsonian monkeysBehavioral recoveryTransporter densityCaudate nucleusNeural graftingDopamine systemImplantation procedureDopamine concentrationsFull behavioral recoveryPutamen of MPTPStriatal dopamine deficiencyStriatal dopamine concentrationsDopamine-depleted striatumStriatum of MPTPDopamine depletionVentral mesencephalonDopamine deficiencyMotor abnormalitiesDopaminergic innervationUseful treatmentStriatal nucleiAdult striatum
1995
Prior exposure to cocaine diminishes behavioral and biochemical responses to aversive conditioning: Reversal by glycine/N-methyl-d-aspartate antagonist co-treatment
Morrow B, Taylor J, Roth R. Prior exposure to cocaine diminishes behavioral and biochemical responses to aversive conditioning: Reversal by glycine/N-methyl-d-aspartate antagonist co-treatment. Neuroscience 1995, 69: 233-240. PMID: 8637621, DOI: 10.1016/0306-4522(95)00184-k.Peer-Reviewed Original ResearchConceptsAversive conditioningAversive conditioning paradigmMedial prefrontal cortexCocaine-exposed groupNeutral stimuliConditioned fearConditioning paradigmPrefrontal cortexHA-966Conditioning sessionsPrior exposureStressful effectsLocomotor stimulant propertiesBehavioral effectsFootshockConditioningN-methyl-D-aspartate antagonistsStressful stimuliAmount of timeFearStimuliN-methyl-D-aspartate (NMDA) receptor complexDoses of cocaineSessionsVentral tegmental areaR-(+)-HA-966, an antagonist for the glycine/NMDA receptor, prevents locomotor sensitization to repeated cocaine exposures
Morrow B, Taylor J, Roth R. R-(+)-HA-966, an antagonist for the glycine/NMDA receptor, prevents locomotor sensitization to repeated cocaine exposures. Brain Research 1995, 673: 165-169. PMID: 7757472, DOI: 10.1016/0006-8993(94)01456-r.Peer-Reviewed Original ResearchConceptsGlycine/NMDA receptorHA-966Locomotor sensitizationLocomotor activationNMDA receptorsCocaine administrationSubsequent challenge doseLocomotor stimulant propertiesNMDA receptor complexAcute stimulant effectsChallenge doseReverse toleranceRepeated administrationAcute doseCocaine exposureStimulant effectsGlycine receptorsStimulant propertiesCocaineSensitizationAdministrationReceptorsReceptor complexAntagonistDose
1994
Preexposure to, but Not Cotreatment with, the Neurotensin Antagonist SR 48692 Delays the Development of Cocaine Sensitization
Horger B, Taylor J, Elsworth J, Roth R. Preexposure to, but Not Cotreatment with, the Neurotensin Antagonist SR 48692 Delays the Development of Cocaine Sensitization. Neuropsychopharmacology 1994, 11: 215-222. PMID: 7865101, DOI: 10.1038/sj.npp.1380108.Peer-Reviewed Original ResearchConceptsCocaine challenge injectionSR 48692Role of neurotensinDevelopment of sensitizationEffects of cocaineCocaine sensitizationChallenge injectionDay drug-free periodMale Sprague-Dawley ratsCocaine-induced locomotor activityDrug-free periodSprague-Dawley ratsCocaine-induced locomotor activationCocaine-induced activityDrug-free daysEffects of cotreatmentPreexposure injectionsDaily administrationLocomotor activationCocaine testLocomotor deficitsLocomotor activityActivity countsChronic preexposureCocaine testingNovel Radioligands for the Dopamine Transporter Demonstrate the Presence of Intrastriatal Nigral Grafts in the MPTP-Treated Monkey: Correlation with Improved Behavioral Function
Elsworth J, Al-Tikriti M, Sladek J, Taylor J, Innis R, Redmond D, Roth R. Novel Radioligands for the Dopamine Transporter Demonstrate the Presence of Intrastriatal Nigral Grafts in the MPTP-Treated Monkey: Correlation with Improved Behavioral Function. Experimental Neurology 1994, 126: 299-304. PMID: 7925828, DOI: 10.1006/exnr.1994.1068.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsAutoradiographyBrain Tissue TransplantationCarrier ProteinsChlorocebus aethiopsCocaineCorpus StriatumDopamine Plasma Membrane Transport ProteinsFetal Tissue TransplantationIodine RadioisotopesMaleMembrane GlycoproteinsMembrane Transport ProteinsNerve Tissue ProteinsParkinson Disease, SecondaryRadioligand AssaySerotonin Plasma Membrane Transport ProteinsSubstantia NigraTransplantation, HeterotopicTransplantation, HomologousConceptsCaudate nucleusFetal ventral mesencephalic cellsIntrastriatal nigral graftsVentral mesencephalic cellsAdult MPTPNigral graftsSerotonergic fibersTransplantation procedureMesencephalic cellsNovel radioligandNeurochemical identityDopamine transporterTransporter sitesSerotonin transporterBehavioral functionsMPTPCocaine analogMonkeysCocaine derivativePreliminary studyHigh affinityDopaminergicGraft
1993
Cocaine-sensitive and -insensitive dopamine uptake in prefrontal cortex, nucleus accumbens and striatum
Elsworth J, Taylor J, Berger P, Roth R. Cocaine-sensitive and -insensitive dopamine uptake in prefrontal cortex, nucleus accumbens and striatum. Neurochemistry International 1993, 23: 61-69. PMID: 8369733, DOI: 10.1016/0197-0186(93)90144-t.Peer-Reviewed Original Research
1991
Cocaethylene: A neuropharmacologically active metabolite assciated with concurrent cocaine-ethanol ingestion
Jatlow P, Elsworth JD, Bradberry CW, Winger G, Taylor JR, Russell R, Roth RH. Cocaethylene: A neuropharmacologically active metabolite assciated with concurrent cocaine-ethanol ingestion. Life Sciences 1991, 48: 1787-1794. PMID: 2020260, DOI: 10.1016/0024-3205(91)90217-y.Peer-Reviewed Original ResearchConceptsDopamine uptake systemEffects of cocaineExtracellular dopamine concentrationBlood of individualsSelf-administration studiesInhibition of bindingEthanol abuseSystemic administrationNucleus accumbensDopamine reuptakeLocomotor activityActive metaboliteDopamine concentrationsBehavioral effectsCocaineEffects of ECRatsVivo formationEquipotentInhibitionSame extent
1990
Cocaethylene inhibits uptake of dopamine and can reach high plasma concentrations following combined cocaine and ethanol use.
Jatlow P, Hearn W, Elsworth J, Roth R, Bradberry C, Taylor J. Cocaethylene inhibits uptake of dopamine and can reach high plasma concentrations following combined cocaine and ethanol use. NIDA Research Monograph 1990, 105: 572-3. PMID: 1876124.Peer-Reviewed Original Research