Featured Publications
Positive modulation of N-methyl-D-aspartate receptors in the mPFC reduces the spontaneous recovery of fear
Lee B, Pothula S, Wu M, Kang H, Girgenti MJ, Picciotto MR, DiLeone RJ, Taylor JR, Duman RS. Positive modulation of N-methyl-D-aspartate receptors in the mPFC reduces the spontaneous recovery of fear. Molecular Psychiatry 2022, 27: 2580-2589. PMID: 35418600, PMCID: PMC9135632, DOI: 10.1038/s41380-022-01498-7.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsExtinction, PsychologicalFearMaleMicePrefrontal CortexRatsRats, Sprague-DawleyReceptors, N-Methyl-D-AspartateConceptsPosttraumatic stress disorderFear extinctionInfralimbic medial prefrontal cortexFear conditioning modelEnhanced fear extinctionFear-based behaviorsProlonged stress modelMedial prefrontal cortexSpontaneous recoveryIL-mPFCPTSD modelPTSD treatmentStress disorderPrefrontal cortexSPS modelN-methyl-D-aspartate receptor modulatorsBrain-derived neurotrophic factorN-methyl-D-aspartate receptorsBehavioral effectsIncreased attentionMPFCPreclinical findingsPyramidal neuronsNeurotrophic factorMale mice
2008
A History of Corticosterone Exposure Regulates Fear Extinction and Cortical NR2B, GluR2/3, and BDNF
Gourley SL, Kedves AT, Olausson P, Taylor JR. A History of Corticosterone Exposure Regulates Fear Extinction and Cortical NR2B, GluR2/3, and BDNF. Neuropsychopharmacology 2008, 34: 707-716. PMID: 18719621, PMCID: PMC3679657, DOI: 10.1038/npp.2008.123.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderConditioned fearFear memory acquisitionFear extinction trainingVentromedial prefrontal cortexContextual fear conditioningMedial orbitofrontal cortexPrior chronic exposureExtinction learningFear extinctionExtinction trainingFear conditioningFear statesImpairs extinctionStress disorderBehavioral flexibilityMemory acquisitionOrbitofrontal cortexPrefrontal cortexNeural systemsAMPA receptor subunitsCortical regionsActive learning processPrior stressGlucocorticoid exposure
1997
Supranormal Stimulation of D1 Dopamine Receptors in the Rodent Prefrontal Cortex Impairs Spatial Working Memory Performance
Zahrt J, Taylor J, Mathew R, Arnsten A. Supranormal Stimulation of D1 Dopamine Receptors in the Rodent Prefrontal Cortex Impairs Spatial Working Memory Performance. Journal Of Neuroscience 1997, 17: 8528-8535. PMID: 9334425, PMCID: PMC6573725, DOI: 10.1523/jneurosci.17-21-08528.1997.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBenzazepinesDopamineDopamine AgonistsDopamine AntagonistsInfusions, ParenteralMaleMaze LearningMemoryModels, NeurologicalModels, PsychologicalPrefrontal CortexPsychomotor PerformanceRatsRats, Sprague-DawleyReceptors, Dopamine D1Receptors, N-Methyl-D-AspartateSpatial BehaviorStress, PsychologicalConceptsD1 receptor stimulationPrefrontal cortexReceptor stimulationSKF 81297SCH 23390D1 receptorsSupranormal stimulationPFC of ratsD1 receptor mechanismsDA receptor stimulationDose-related impairmentD1 receptor antagonistD1 receptor agonistD1 dopamine receptorsDelayed-alternation performanceMemory functionRecent electrophysiological studiesSpatial Working Memory PerformanceReceptor antagonistReceptor agonistDopamine receptorsReceptor mechanismsElectrophysiological studiesHigh dosesDrug efficacy
1995
Prior exposure to cocaine diminishes behavioral and biochemical responses to aversive conditioning: Reversal by glycine/N-methyl-d-aspartate antagonist co-treatment
Morrow B, Taylor J, Roth R. Prior exposure to cocaine diminishes behavioral and biochemical responses to aversive conditioning: Reversal by glycine/N-methyl-d-aspartate antagonist co-treatment. Neuroscience 1995, 69: 233-240. PMID: 8637621, DOI: 10.1016/0306-4522(95)00184-k.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAvoidance LearningBehavior, AnimalBrainCocaineConditioning, PsychologicalDopamineElectroshockGlycineMalePyrrolidinonesRatsRats, Sprague-DawleyReceptors, N-Methyl-D-AspartateSerotoninConceptsAversive conditioningAversive conditioning paradigmMedial prefrontal cortexCocaine-exposed groupNeutral stimuliConditioned fearConditioning paradigmPrefrontal cortexHA-966Conditioning sessionsPrior exposureStressful effectsLocomotor stimulant propertiesBehavioral effectsFootshockConditioningN-methyl-D-aspartate antagonistsStressful stimuliAmount of timeFearStimuliN-methyl-D-aspartate (NMDA) receptor complexDoses of cocaineSessionsVentral tegmental areaR-(+)-HA-966, an antagonist for the glycine/NMDA receptor, prevents locomotor sensitization to repeated cocaine exposures
Morrow B, Taylor J, Roth R. R-(+)-HA-966, an antagonist for the glycine/NMDA receptor, prevents locomotor sensitization to repeated cocaine exposures. Brain Research 1995, 673: 165-169. PMID: 7757472, DOI: 10.1016/0006-8993(94)01456-r.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AnimalCocaineFrontal LobeMaleMotor ActivityPyrrolidinonesRatsRats, Sprague-DawleyReceptors, GlycineReceptors, N-Methyl-D-AspartateTime FactorsConceptsGlycine/NMDA receptorHA-966Locomotor sensitizationLocomotor activationNMDA receptorsCocaine administrationSubsequent challenge doseLocomotor stimulant propertiesNMDA receptor complexAcute stimulant effectsChallenge doseReverse toleranceRepeated administrationAcute doseCocaine exposureStimulant effectsGlycine receptorsStimulant propertiesCocaineSensitizationAdministrationReceptorsReceptor complexAntagonistDose