Featured Publications
Dysregulation of Decision Making Related to Metabotropic Glutamate 5, but Not Midbrain D3, Receptor Availability Following Cocaine Self-administration in Rats
Groman SM, Hillmer AT, Liu H, Fowles K, Holden D, Morris ED, Lee D, Taylor JR. Dysregulation of Decision Making Related to Metabotropic Glutamate 5, but Not Midbrain D3, Receptor Availability Following Cocaine Self-administration in Rats. Biological Psychiatry 2020, 88: 777-787. PMID: 32826065, PMCID: PMC8935943, DOI: 10.1016/j.biopsych.2020.06.020.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCocaineCocaine-Related DisordersDecision MakingGlutamic AcidMesencephalonRatsSelf AdministrationConceptsCocaine-dependent individualsProbabilistic reversalRelapse-like behaviorTest of motivationReceptor availabilityPersistent drug useMetabotropic glutamate 5Neural mechanismsCompulsive patternsDecision-making processDrug-induced adaptationsSelective impairmentDrug useWeeks of abstinenceCocaine takingCocaine Self-AdministrationBrain regionsDegree of disruptionDays of cocaineAdult male ratsCocaine-induced increasesCocaine-induced changesDrug-induced alterationsRobust alterationsPositron emission tomography
2008
Targeting extinction and reconsolidation mechanisms to combat the impact of drug cues on addiction
Taylor JR, Olausson P, Quinn JJ, Torregrossa MM. Targeting extinction and reconsolidation mechanisms to combat the impact of drug cues on addiction. Neuropharmacology 2008, 56: 186-195. PMID: 18708077, PMCID: PMC2635342, DOI: 10.1016/j.neuropharm.2008.07.027.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsConditioning, OperantCuesExtinction, PsychologicalHumansSelf AdministrationSubstance-Related DisordersConceptsCue-drug memoriesCue-drug associationsCue exposure therapyMemory reconsolidation processesDisruption of reconsolidationCue-induced relapseDrug-associated cuesInhibitory memoryReconsolidation mechanismsDrug cuesMemory retrievalReconsolidation processMemory processesReconsolidationCompulsive disorderRelapse behaviorMemoryMemory erasureBrief time periodDrug addictionDistinct processesCuesAddictionExtinctionCraving
2005
Persistent changes in motivation to self‐administer cocaine following modulation of cyclic AMP‐dependent protein kinase A (PKA) activity in the nucleus accumbens
Lynch W, Taylor J. Persistent changes in motivation to self‐administer cocaine following modulation of cyclic AMP‐dependent protein kinase A (PKA) activity in the nucleus accumbens. European Journal Of Neuroscience 2005, 22: 1214-1220. PMID: 16176364, DOI: 10.1111/j.1460-9568.2005.04305.x.Peer-Reviewed Original Research
1991
Cocaethylene: A neuropharmacologically active metabolite assciated with concurrent cocaine-ethanol ingestion
Jatlow P, Elsworth JD, Bradberry CW, Winger G, Taylor JR, Russell R, Roth RH. Cocaethylene: A neuropharmacologically active metabolite assciated with concurrent cocaine-ethanol ingestion. Life Sciences 1991, 48: 1787-1794. PMID: 2020260, DOI: 10.1016/0024-3205(91)90217-y.Peer-Reviewed Original ResearchConceptsDopamine uptake systemEffects of cocaineExtracellular dopamine concentrationBlood of individualsSelf-administration studiesInhibition of bindingEthanol abuseSystemic administrationNucleus accumbensDopamine reuptakeLocomotor activityActive metaboliteDopamine concentrationsBehavioral effectsCocaineEffects of ECRatsVivo formationEquipotentInhibitionSame extent