1999
Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli
Jentsch J, Taylor J. Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli. Psychopharmacology 1999, 146: 373-390. PMID: 10550488, DOI: 10.1007/pl00005483.Peer-Reviewed Original ResearchConceptsControl of behaviorInhibitory controlIncentive learning processesDrug abuseInhibitory response controlReward-related stimuliDrug-seeking behaviorChronic drug useCognitive impulsivityMotivational processesRelated stimuliMotivational qualitiesFrontostriatal systemFrontostriatal dysfunctionDrug seekingDrugs of abuseNeuro-anatomicalVentral striatumDrive stateAllocation of behaviorAppropriate behavioral patternsCognitive dysfunctionResponse controlFrontal cortexPrimate brain
1998
Upregulation of striatal D2 receptors in the MPTP-treated vervet monkey is reversed by grafts of fetal ventral mesencephalon: an autoradiographic study
Elsworth J, Brittan M, Taylor J, Sladek J, Redmond D, Innis R, Zea-Ponce Y, Roth R. Upregulation of striatal D2 receptors in the MPTP-treated vervet monkey is reversed by grafts of fetal ventral mesencephalon: an autoradiographic study. Brain Research 1998, 795: 55-62. PMID: 9622593, DOI: 10.1016/s0006-8993(98)00252-2.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsAutoradiographyBenzofuransBrain Tissue TransplantationChlorocebus aethiopsCorpus StriatumDisease Models, AnimalDopamine AgentsFetal Tissue TransplantationImage Processing, Computer-AssistedIodine RadioisotopesMesencephalonParkinson Disease, SecondaryRadioligand AssayReceptors, Dopamine D2Up-RegulationConceptsFetal ventral mesencephalonD2 receptor bindingVentral mesencephalonDorsal striatumAutoradiographic studyDopamine uptake site densityPostsynaptic dopamine receptor activationVentral striatumDopamine concentrationsStriatal D2 receptor bindingReceptor bindingD2 receptor upregulationPostsynaptic dopamine transmissionTetrahydropyridine-treated monkeysStriatal D2 receptorsDopamine receptor activationPrevious autoradiographic studiesAfrican green monkeysDonor neuronsIntrastriatal graftingParkinsonian primatesNeural transplantationReceptor upregulationStriatal circuitryMotor function
1989
Limbic-striatal interactions in reward-related processes
Robbins T, Cador M, Taylor J, Everitt B. Limbic-striatal interactions in reward-related processes. Neuroscience & Biobehavioral Reviews 1989, 13: 155-162. PMID: 2682402, DOI: 10.1016/s0149-7634(89)80025-9.Peer-Reviewed Original ResearchConceptsVentral striatumDA depletionIndirect dopamine agonist d-amphetamineStriatal DA depletionReward-related stimuliAgonist d-amphetamineSelective stimulatory effectDA-dependent processesBasolateral nucleusD-amphetamineExcitotoxic lesionsReward-related processesSecond-order scheduleDorsal striatumStriatumAmygdala lesionsStimulatory effectLesionsSimilar discriminative propertiesDiscriminative propertiesOrder schedulePredictive associationsSexual reinforcementDorsalParallel findings