2023
Examining mGlu5 Receptor Availability as a Predictor of Vulnerability to PTSD: An [18F]FPEB and PET Study in Male and Female Rats
Asch R, Fowles K, Pietrzak R, Taylor J, Esterlis I. Examining mGlu5 Receptor Availability as a Predictor of Vulnerability to PTSD: An [18F]FPEB and PET Study in Male and Female Rats. Chronic Stress 2023, 7: 24705470231215001. PMID: 38024327, PMCID: PMC10666551, DOI: 10.1177/24705470231215001.Peer-Reviewed Original ResearchPost-traumatic stress disorderReceptor availabilityFemale ratsPathophysiology of PTSDFootshock exposureMetabotropic glutamate receptor 5Recent preclinical findingsGlutamate receptor 5Positron emission tomographyPreclinical findingsClinical findingsFe ratsReceptor 5Lower baselineEmission tomographyGreater riskPET studiesRatsStress disorderDifferential involvementPassive copingSex differencesMalesPTSD susceptibilityBaseline
1998
Subchronic Phencyclidine Administration Increases Mesolimbic Dopaminergic System Responsivity and Augments Stress- and Psychostimulant-Induced Hyperlocomotion
Jentsch J, Taylor J, Roth R. Subchronic Phencyclidine Administration Increases Mesolimbic Dopaminergic System Responsivity and Augments Stress- and Psychostimulant-Induced Hyperlocomotion. Neuropsychopharmacology 1998, 19: 105-113. PMID: 9629564, DOI: 10.1016/s0893-133x(98)00004-9.Peer-Reviewed Original ResearchMeSH Keywords3,4-Dihydroxyphenylacetic AcidAnalysis of VarianceAnimalsBrainDextroamphetamineDisease Models, AnimalDizocilpine MaleateDopamineDrug Administration ScheduleHaloperidolLimbic SystemMaleMotor ActivityPhencyclidinePrefrontal CortexRatsRats, Sprague-DawleySchizophreniaStress, PsychologicalTime FactorsConceptsDopamine utilizationHaloperidol-induced increasePCP exposureFrontal cortical dysfunctionAmphetamine-induced hyperlocomotionSubchronic PCP administrationMesolimbic dopamine transmissionPCP-treated ratsCortical dopaminergicCortical dysfunctionDopaminergic deficitDopaminergic transmissionDopaminergic functionDopamine transmissionDopaminergic hypoactivityPCP administrationBehavioral pathologyCognitive deficitsRatsSystem responsivityHyperlocomotionDopaminergicExposureCurrent studyDeficits
1996
Sensitization to the locomotor activating effects of cocaine following cocaethylene-preexposure
Horger B, Taylor J, Elsworth J, Jatlow P, Roth R. Sensitization to the locomotor activating effects of cocaine following cocaethylene-preexposure. Brain Research 1996, 733: 133-137. PMID: 8891259, DOI: 10.1016/0006-8993(96)00783-4.Peer-Reviewed Original Research
1991
Cocaethylene: A neuropharmacologically active metabolite assciated with concurrent cocaine-ethanol ingestion
Jatlow P, Elsworth JD, Bradberry CW, Winger G, Taylor JR, Russell R, Roth RH. Cocaethylene: A neuropharmacologically active metabolite assciated with concurrent cocaine-ethanol ingestion. Life Sciences 1991, 48: 1787-1794. PMID: 2020260, DOI: 10.1016/0024-3205(91)90217-y.Peer-Reviewed Original ResearchConceptsDopamine uptake systemEffects of cocaineExtracellular dopamine concentrationBlood of individualsSelf-administration studiesInhibition of bindingEthanol abuseSystemic administrationNucleus accumbensDopamine reuptakeLocomotor activityActive metaboliteDopamine concentrationsBehavioral effectsCocaineEffects of ECRatsVivo formationEquipotentInhibitionSame extent