2022
Utility and Implementation of Oral Corticosteroid Exposure in Behavioral Neuroscience Research with Rodents
Sequeira M, Taylor J, Gourley S. Utility and Implementation of Oral Corticosteroid Exposure in Behavioral Neuroscience Research with Rodents. Neuromethods 2022, 190: 223-231. DOI: 10.1007/978-1-0716-2748-8_12.Peer-Reviewed Original ResearchChronic antidepressant treatmentChronic CORT exposureDepression-like phenomenaHelplessness-like behaviorOral corticosteroid exposureDepressive-like stateNeurobiology of depressionChronic mild stressCohort of animalsMultiple biological factorsCorticosteroid exposureAntidepressant actionAntidepressant treatmentAdrenal hormonesC57BL/6 miceCORT exposureResilient miceNaïve rodentsMild stressExposure resultsMiceExposure procedureCorticosteroneExposure periodDepression
2009
Recapitulation and Reversal of a Persistent Depression‐like Syndrome in Rodents
Gourley SL, Taylor JR. Recapitulation and Reversal of a Persistent Depression‐like Syndrome in Rodents. Current Protocols In Neuroscience 2009, 49: 9.32.1-9.32.11. PMID: 19802817, PMCID: PMC2774936, DOI: 10.1002/0471142301.ns0932s49.Peer-Reviewed Original ResearchConceptsCORT exposureChronic mild stress modelChronic antidepressant treatmentChronic CORT exposureHelplessness-like behaviorDepressive-like stateNeurobiology of depressionDepression-like syndromeChronic oral exposureAntidepressant efficacyAntidepressant treatmentAdrenal hormonesOral exposureNucleus accumbensMouse modelFeelings of anhedoniaNaïve rodentsMultiple biological functionsMolecular targetsCAMP response elementDepressionFactor activityCorticosteroneExposure periodExposure