1998
Pattern of synaptophysin immunoreactivity within mesencephalic grafts following transplantation in a parkinsonian primate model
Sortwell C, Blanchard B, Collier T, Elsworth J, Taylor J, Roth R, Redmond D, Sladek J. Pattern of synaptophysin immunoreactivity within mesencephalic grafts following transplantation in a parkinsonian primate model. Brain Research 1998, 791: 117-124. PMID: 9593853, DOI: 10.1016/s0006-8993(98)00086-9.Peer-Reviewed Original ResearchConceptsGraft-host interactionsMesencephalic graftsFunctional synapsesTyrosine hydroxylaseCerebellar tissuePericellular arraysEmbryonic cerebellar tissueEmbryonic ventral mesencephalonGrafted dopamine neuronsNerve terminal differentiationTH-positive neuronsStriatum of MPTPEnzyme tyrosine hydroxylaseSynthetic enzyme tyrosine hydroxylaseAfrican green monkeysNeurochemical subtypesStriatal portionDA neuronsSynaptophysin immunoreactivityVentral mesencephalonGraft typeDopamine neuronsPrimate modelStriatal targetsSynaptic remodeling
1996
Early gestational mesencephalon grafts, but not later gestational mesencephalon, cerebellum or sham grafts, increase dopamine in caudate nucleus of MPTP-treated monkeys
Elsworth J, Sladek J, Taylor J, Collier T, Redmond D, Roth R. Early gestational mesencephalon grafts, but not later gestational mesencephalon, cerebellum or sham grafts, increase dopamine in caudate nucleus of MPTP-treated monkeys. Neuroscience 1996, 72: 477-484. PMID: 8737417, DOI: 10.1016/0306-4522(95)00564-1.Peer-Reviewed Original ResearchConceptsFetal ventral mesencephalonVentral mesencephalonCaudate nucleusGraft siteDopamine neuronsDopamine concentrationsBehavioral recoveryTyrosine hydroxylase-positive neuronsHomovanillic acid/dopamine ratioFetal dopamine neuronsGrafted dopamine neuronsIntrastriatal transplantsParkinsonian primatesGrafted neuronsIntrastriatal transplantationGestational ageTransplant proceduresDopamine ratioDopamine productionSignificant elevationNucleus accumbensDopamine systemSham graftsGraftBrain regions
1994
Peripheral nerve-dopamine neuron co-grafts in mptp-treated monkeys: Augmentation of tyrosine hydroxylase-positive fiber staining and dopamine content in host systems
Collier T, Elsworth J, Taylor J, Sladek J, Roth R, Redmond D. Peripheral nerve-dopamine neuron co-grafts in mptp-treated monkeys: Augmentation of tyrosine hydroxylase-positive fiber staining and dopamine content in host systems. Neuroscience 1994, 61: 875-889. PMID: 7838385, DOI: 10.1016/0306-4522(94)90410-3.Peer-Reviewed Original ResearchConceptsDopamine neuronsCaudate nucleusNon-human primatesLateral ventricleSeptal areaDopamine systemEmbryonic ventral mesencephalic tissueTyrosine hydroxylase-positive fibersHomovanillic acid/dopamine ratioDopamine neuron graftsDopamine-depleted monkeysEmbryonic ventral mesencephalonGrafted dopamine neuronsVentral mesencephalic tissueLateral septal areaLevels of dopamineMesencephalic dopamine neuronsMetabolite homovanillic acidBrain dopamine systemsMPTP-treated monkeysDirection of normalizationAfrican green monkeysInjury-induced regenerationMesencephalic tissueSaphenous nerve
1993
Can Graft-Derived Neurotrophic Activity Be Used to Direct Axonal Outgrowth of Grafted Dopamine Neurons for Circuit Reconstruction in Primates?
Sladek J, Collier T, Elsworth J, Taylor J, Roth R, Redmond D. Can Graft-Derived Neurotrophic Activity Be Used to Direct Axonal Outgrowth of Grafted Dopamine Neurons for Circuit Reconstruction in Primates? Experimental Neurology 1993, 124: 134-139. PMID: 8282070, DOI: 10.1006/exnr.1993.1184.Peer-Reviewed Original ResearchConceptsGrafted dopamine neuronsDopamine neuronsNeurotrophic activityAxonal outgrowthCircuit reconstructionGraftNeurons