A History of Corticosterone Exposure Regulates Fear Extinction and Cortical NR2B, GluR2/3, and BDNF
Gourley SL, Kedves AT, Olausson P, Taylor JR. A History of Corticosterone Exposure Regulates Fear Extinction and Cortical NR2B, GluR2/3, and BDNF. Neuropsychopharmacology 2008, 34: 707-716. PMID: 18719621, PMCID: PMC3679657, DOI: 10.1038/npp.2008.123.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderConditioned fearFear memory acquisitionFear extinction trainingVentromedial prefrontal cortexContextual fear conditioningMedial orbitofrontal cortexPrior chronic exposureExtinction learningFear extinctionExtinction trainingFear conditioningFear statesImpairs extinctionStress disorderBehavioral flexibilityMemory acquisitionOrbitofrontal cortexPrefrontal cortexNeural systemsAMPA receptor subunitsCortical regionsActive learning processPrior stressGlucocorticoid exposure