2000
Role for dopamine in the behavioral functions of the prefrontal corticostriatal system: implications for mental disorders and psychotropic drug action
Jentsch J, Roth R, Taylor J. Role for dopamine in the behavioral functions of the prefrontal corticostriatal system: implications for mental disorders and psychotropic drug action. Progress In Brain Research 2000, 126: 433-453. PMID: 11105661, DOI: 10.1016/s0079-6123(00)26028-7.Peer-Reviewed Original ResearchMeSH KeywordsAmphetaminesAmygdalaAnimalsBehaviorBrain MappingCentral Nervous System StimulantsCognitionCorpus StriatumDepressionDopamineDopamine AgonistsEmotionsHaplorhiniHumansLearningLimbic SystemMammalsMemoryMental DisordersNeural PathwaysNeurotransmitter AgentsNucleus AccumbensPhencyclidinePrefrontal CortexPsychotropic DrugsReceptors, NeurotransmitterRewardSchizophreniaSubstance-Related DisordersConceptsForebrain sitesPsychotropic drug actionPrecise anatomical sitesRole of dopamineDopaminergic dysfunctionDopaminergic transmissionDopaminergic functionDopamine neuronsDopaminergic responseReward-related stimuliCorticolimbic circuitsChronic activationDopaminergic activationStriatal regionsAfferent controlAnatomical sitesCorticostriatal systemMental disordersNeuropsychiatric disordersNeuromodulatory systemsPersistent neuroadaptationsDrug actionBehavioral functionsCellular mechanismsDopamine
1998
Prefrontal cortical involvement in phencyclidine-induced activation of the mesolimbic dopamine system: behavioral and neurochemical evidence
Jentsch J, Tran A, Taylor J, Roth R. Prefrontal cortical involvement in phencyclidine-induced activation of the mesolimbic dopamine system: behavioral and neurochemical evidence. Psychopharmacology 1998, 138: 89-95. PMID: 9694531, DOI: 10.1007/s002130050649.Peer-Reviewed Original ResearchConceptsMesolimbic dopamine systemPrefrontal cortexInduced hyperlocomotionDopamine neuronsDopamine releaseNucleus accumbensDopamine systemInjection of phencyclidineMesocorticolimbic dopaminergic neuronsMesolimbic dopamine neuronsVentral tegmental areaCell body regionIbotenic acid lesionsPrefrontal Cortical InvolvementProfound cognitive impairmentGlutamatergic releaseNeurochemical evidenceAcute administrationCortical involvementDopamine utilizationDopaminergic neuronsMesolimbic pathwayTegmental areaAcid lesionsDopaminergic activation