1998
In vivo expression of therapeutic human genes for dopamine production in the caudates of MPTP-treated monkeys using an AAV vector
During M, Samulski R, Elsworth J, Kaplitt M, Leone P, Xiao X, Li J, Freese A, Taylor J, Roth R, Sladek J, O’Malley K, Redmond D. In vivo expression of therapeutic human genes for dopamine production in the caudates of MPTP-treated monkeys using an AAV vector. Gene Therapy 1998, 5: 820-827. PMID: 9747462, DOI: 10.1038/sj.gt.3300650.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsAromatic-L-Amino-Acid DecarboxylasesChlorocebus aethiopsDependovirusDopamineDopamine AgentsGene ExpressionGene Transfer TechniquesGenetic VectorsHumansImmunohistochemistryMaleParkinson DiseaseTrigeminal Caudal NucleusTyrosine 3-MonooxygenaseConceptsTyrosine hydroxylaseStriatal cellsDopamine-depleted monkeysAdeno-associated virus vectorProduction of dopamineParkinsonian monkeysTransient feverSevere hyperactivityStriatal dopaminePrimate neuronsStereotactic injectionHistological evidencePrimate modelInjection tractNeurotoxin MPTPDopamine productionParkinson's diseaseTreatment groupsSignificant toxicityBehavioral effectsVivo gene therapyElevated levelsBiochemical effectsFirst dayMonkeys
1996
Early gestational mesencephalon grafts, but not later gestational mesencephalon, cerebellum or sham grafts, increase dopamine in caudate nucleus of MPTP-treated monkeys
Elsworth J, Sladek J, Taylor J, Collier T, Redmond D, Roth R. Early gestational mesencephalon grafts, but not later gestational mesencephalon, cerebellum or sham grafts, increase dopamine in caudate nucleus of MPTP-treated monkeys. Neuroscience 1996, 72: 477-484. PMID: 8737417, DOI: 10.1016/0306-4522(95)00564-1.Peer-Reviewed Original ResearchConceptsFetal ventral mesencephalonVentral mesencephalonCaudate nucleusGraft siteDopamine neuronsDopamine concentrationsBehavioral recoveryTyrosine hydroxylase-positive neuronsHomovanillic acid/dopamine ratioFetal dopamine neuronsGrafted dopamine neuronsIntrastriatal transplantsParkinsonian primatesGrafted neuronsIntrastriatal transplantationGestational ageTransplant proceduresDopamine ratioDopamine productionSignificant elevationNucleus accumbensDopamine systemSham graftsGraftBrain regions
1990
Chapter 62 Improvements in MPTP-induced object retrieval deficits and behavioral deficits after fetal nigral grafting in monkeys
Taylor J, Elsworth J, Roth R, Collier T, Sladek J, Redmond D. Chapter 62 Improvements in MPTP-induced object retrieval deficits and behavioral deficits after fetal nigral grafting in monkeys. Progress In Brain Research 1990, 82: 543-559. PMID: 2290957, DOI: 10.1016/s0079-6123(08)62645-x.Peer-Reviewed Original ResearchConceptsCSF HVA levelsHVA levelsBehavioral recoveryCaudate nucleusSN graftsDopamine neuronsDopamine productionHVA/dopamine ratioCentral dopamine productionFetal substantia nigraStriatum of subjectsSubstantia nigra transplantsRelease of dopamineImproved parkinsonismHost striatumHost brainFetal graftsMPTP administrationParkinsonian signsTH immunohistochemistrySubstantia nigraDopamine ratioSmall graftsBehavioral deficitsGraft