2023
Using dimensionality-reduction techniques to understand the organization of psychotic symptoms in persistent psychotic illness and first episode psychosis
Fleming L, Lemonde A, Benrimoh D, Gold J, Taylor J, Malla A, Joober R, Iyer S, Lepage M, Shah J, Corlett P. Using dimensionality-reduction techniques to understand the organization of psychotic symptoms in persistent psychotic illness and first episode psychosis. Scientific Reports 2023, 13: 4841. PMID: 36964175, PMCID: PMC10039017, DOI: 10.1038/s41598-023-31909-w.Peer-Reviewed Original ResearchConceptsHallucinations/delusionsFirst-episode psychosisFirst-episode psychosis participantsEarly intervention programsPathophysiological mechanismsUnderlying pathophysiologyEpisode psychosisPsychotic illnessPsychotic symptomsPsychotic disordersSchizoaffective disorderAuditory hallucinationsPositive symptomsHallucination severityNegative symptomsSymptomsDisorganization symptomsIntervention programsHallucinationsIllnessPsychosis participantsPsychosisDelusionsDisordersParticipants
2013
Chapter 13 The Translational Potential of Memory Reconsolidation
Corlett P, Taylor J. Chapter 13 The Translational Potential of Memory Reconsolidation. 2013, 273-292. DOI: 10.1016/b978-0-12-386892-3.00013-5.Peer-Reviewed Original ResearchPost-traumatic stress disorderMemory labileMemory reconsolidationMemory processingLabile stateStress disorderMemory erasureDrug addictionPast experienceReconsolidationSerious mental illnessCurrent processingMemoryMental illnessProcessingAddictionEthical implicationsChapter 13PsychosisDisordersImplicationsIllnessExperience
2000
Phencyclidine Model of Frontal Cortical Dysfunction in Nonhuman Primates
Jentsch J, Taylor J, Roth R. Phencyclidine Model of Frontal Cortical Dysfunction in Nonhuman Primates. The Neuroscientist 2000, 6: 263-270. DOI: 10.1177/107385840000600409.Peer-Reviewed Original ResearchPrefrontal cortexFrontal cortical dysfunctionPCP-induced behaviorsIdiopathic psychotic disordersPathophysiology of schizophreniaSchizophrenia-like symptomatologyLong-term intakeDopaminergic interactionsCortical dysfunctionNeurochemical dysfunctionNeurochemical effectsReceptor antagonistCognitive dysfunctionPhencyclidine modelPrimary symptomsPsychotic disordersDysfunctionNonhuman primatesNeurobiological substratesHuman subjectsBehavioral changesCortexSchizophreniaDisordersAberrant behavior
1999
α-1 noradrenergic receptor stimulation impairs prefrontal cortical cognitive function
Arnsten A, Mathew R, Ubriani R, Taylor J, Li B. α-1 noradrenergic receptor stimulation impairs prefrontal cortical cognitive function. Biological Psychiatry 1999, 45: 26-31. PMID: 9894572, DOI: 10.1016/s0006-3223(98)00296-0.Peer-Reviewed Original ResearchConceptsPrefrontal cortexCognitive functionPrefrontal cortical cognitive functionCortical cognitive functionsImpairs cognitive functionHigher cortical functionsMemory taskAlpha-1 adrenoceptorsMost antipsychotic medicationsAlternation performanceNoradrenergic turnoverCortical functionPhenylephrine responseAlpha-1 adrenoceptor stimulationNeuropsychiatric disordersAlpha-1 adrenergic antagonistAlpha-1 adrenergic agonistDisordersAntipsychotic medicationAnxietyHigh levelsPhenylephrine infusionAdrenoceptor stimulationAdrenergic antagonistsSecond messenger pathways