1999
Enhancement of Locomotor Activity and Conditioned Reward to Cocaine by Brain-Derived Neurotrophic Factor
Horger B, Iyasere C, Berhow M, Messer C, Nestler E, Taylor J. Enhancement of Locomotor Activity and Conditioned Reward to Cocaine by Brain-Derived Neurotrophic Factor. Journal Of Neuroscience 1999, 19: 4110-4122. PMID: 10234039, PMCID: PMC6782687, DOI: 10.1523/jneurosci.19-10-04110.1999.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorDevelopment of sensitizationLocomotor sensitizationBDNF infusionNeurotrophic factorNucleus accumbensStimulant effectsInitial stimulant effectMesolimbic DA systemCocaine-induced locomotionVentral tegmental areaMesolimbic dopamine systemWild-type littermatesPsychomotor stimulant effectsBDNF administrationDopaminergic neuronsTegmental areaCocaine injectionCocaine dosesControl animalsDopamine systemLocomotor activityDrug rewardCR leverDA system
1997
Dysregulation of Mesoprefrontal Dopamine Neurons Induced by Acute and Repeated Phencyclidine Administration in the Nonhuman Primate: Implications for Schizophrenia
Jentsch J, Elsworth J, Taylor J, Redmond D, Roth R. Dysregulation of Mesoprefrontal Dopamine Neurons Induced by Acute and Repeated Phencyclidine Administration in the Nonhuman Primate: Implications for Schizophrenia. Advances In Pharmacology 1997, 42: 810-814. PMID: 9328021, DOI: 10.1016/s1054-3589(08)60870-4.Peer-Reviewed Original ResearchConceptsPCP administrationAcute PCP administrationNegative symptomsDA systemMesoprefrontal dopamine neuronsSubcortical DA systemsBrains of patientsSchizophrenia-like symptomatologyDevelopment of neuropathologyDistinct behavioral effectsDAergic dysfunctionDA metabolismDAergic functionDopamine neuronsCognitive dysfunctionNovel agentsDeficits of schizophreniaFrontal cortexPsychotomimetic propertiesNeurobiological effectsDopamine systemPositive symptomsPhencyclidine administrationBehavioral effectsAdministration