2008
A History of Corticosterone Exposure Regulates Fear Extinction and Cortical NR2B, GluR2/3, and BDNF
Gourley SL, Kedves AT, Olausson P, Taylor JR. A History of Corticosterone Exposure Regulates Fear Extinction and Cortical NR2B, GluR2/3, and BDNF. Neuropsychopharmacology 2008, 34: 707-716. PMID: 18719621, PMCID: PMC3679657, DOI: 10.1038/npp.2008.123.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderConditioned fearFear memory acquisitionFear extinction trainingVentromedial prefrontal cortexContextual fear conditioningMedial orbitofrontal cortexPrior chronic exposureExtinction learningFear extinctionExtinction trainingFear conditioningFear statesImpairs extinctionStress disorderBehavioral flexibilityMemory acquisitionOrbitofrontal cortexPrefrontal cortexNeural systemsAMPA receptor subunitsCortical regionsActive learning processPrior stressGlucocorticoid exposure
1995
Prior exposure to cocaine diminishes behavioral and biochemical responses to aversive conditioning: Reversal by glycine/N-methyl-d-aspartate antagonist co-treatment
Morrow B, Taylor J, Roth R. Prior exposure to cocaine diminishes behavioral and biochemical responses to aversive conditioning: Reversal by glycine/N-methyl-d-aspartate antagonist co-treatment. Neuroscience 1995, 69: 233-240. PMID: 8637621, DOI: 10.1016/0306-4522(95)00184-k.Peer-Reviewed Original ResearchConceptsAversive conditioningAversive conditioning paradigmMedial prefrontal cortexCocaine-exposed groupNeutral stimuliConditioned fearConditioning paradigmPrefrontal cortexHA-966Conditioning sessionsPrior exposureStressful effectsLocomotor stimulant propertiesBehavioral effectsFootshockConditioningN-methyl-D-aspartate antagonistsStressful stimuliAmount of timeFearStimuliN-methyl-D-aspartate (NMDA) receptor complexDoses of cocaineSessionsVentral tegmental area