2022
Utility and Implementation of Oral Corticosteroid Exposure in Behavioral Neuroscience Research with Rodents
Sequeira M, Taylor J, Gourley S. Utility and Implementation of Oral Corticosteroid Exposure in Behavioral Neuroscience Research with Rodents. Neuromethods 2022, 190: 223-231. DOI: 10.1007/978-1-0716-2748-8_12.Peer-Reviewed Original ResearchChronic antidepressant treatmentChronic CORT exposureDepression-like phenomenaHelplessness-like behaviorOral corticosteroid exposureDepressive-like stateNeurobiology of depressionChronic mild stressCohort of animalsMultiple biological factorsCorticosteroid exposureAntidepressant actionAntidepressant treatmentAdrenal hormonesC57BL/6 miceCORT exposureResilient miceNaïve rodentsMild stressExposure resultsMiceExposure procedureCorticosteroneExposure periodDepression
2011
Induction of Persistent Depressive-Like Behavior by Corticosterone
Gourley S, Taylor J. Induction of Persistent Depressive-Like Behavior by Corticosterone. Neuromethods 2011, 63: 251-265. DOI: 10.1007/978-1-61779-313-4_16.Peer-Reviewed Original ResearchChronic CORT exposureDepressive-like behaviorCORT exposureChronic depressive-like stateChronic mild stress modelStress-related mood disordersChronic antidepressant treatmentSerum CORT levelsNeurobiology of depressionDepressive-like stateChronic oral exposureCharacteristics of depressionAntidepressant efficacyAntidepressant treatmentAdrenal hormonesOral exposureMood disordersFeelings of anhedoniaLocomotor activityNaïve rodentsCORT levelsCorticosteroneDepressionBehavioral consequencesExposure
2009
Recapitulation and Reversal of a Persistent Depression‐like Syndrome in Rodents
Gourley SL, Taylor JR. Recapitulation and Reversal of a Persistent Depression‐like Syndrome in Rodents. Current Protocols In Neuroscience 2009, 49: 9.32.1-9.32.11. PMID: 19802817, PMCID: PMC2774936, DOI: 10.1002/0471142301.ns0932s49.Peer-Reviewed Original ResearchConceptsCORT exposureChronic mild stress modelChronic antidepressant treatmentChronic CORT exposureHelplessness-like behaviorDepressive-like stateNeurobiology of depressionDepression-like syndromeChronic oral exposureAntidepressant efficacyAntidepressant treatmentAdrenal hormonesOral exposureNucleus accumbensMouse modelFeelings of anhedoniaNaïve rodentsMultiple biological functionsMolecular targetsCAMP response elementDepressionFactor activityCorticosteroneExposure periodExposure
2008
Acute Hippocampal Brain-Derived Neurotrophic Factor Restores Motivational and Forced Swim Performance After Corticosterone
Gourley SL, Kiraly DD, Howell JL, Olausson P, Taylor JR. Acute Hippocampal Brain-Derived Neurotrophic Factor Restores Motivational and Forced Swim Performance After Corticosterone. Biological Psychiatry 2008, 64: 884-890. PMID: 18675955, PMCID: PMC2633780, DOI: 10.1016/j.biopsych.2008.06.016.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorHippocampal brain-derived neurotrophic factorAntidepressant treatmentCORT exposureCORT secretionAppetitive instrumental behaviorChronic antidepressant treatmentDepressive-like stateNeurobiology of depressionHippocampal BDNF expressionAdult male miceAnhedonic-like behaviorResponse Element-Binding Protein PhosphorylationCAMP response element-binding protein (CREB) phosphorylationProgressive ratio taskElement-Binding Protein PhosphorylationADT efficacyCORT modelAntidepressant efficacyBDNF expressionHippocampal brainNeurotrophic factorSwim testCorticosterone exposureMale mice